European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs - a GA2LEN initiative

Allergy ◽  
2006 ◽  
Vol 61 (2) ◽  
pp. 221-228 ◽  
Author(s):  
T. Keil ◽  
M. Kulig ◽  
A. Simpson ◽  
A. Custovic ◽  
M. Wickman ◽  
...  
2021 ◽  
Vol 6 (1) ◽  
pp. 22
Author(s):  
Eleni Fthenou ◽  
Samah Aboulsoud ◽  
Vasiliki Leventakou ◽  
Alexandra Haddad ◽  
Manolis Kogevinas ◽  
...  

Mother-Child and Birth cohort studies offer an excellent opportunity to evaluate the effects of ’early life’ exposures providing an insight in the etiology of chronic diseases. To our knowledge, this is the first study that aims to provide a comprehensive review of these studies in the Middle East Area (MEA). Authors searched to relevant registries, the Pubmed interface, internet search tools and had personal contact with study PIs. The search revealed 117 mother-child and birth cohort studies from 9 MEA region countries (Iran, Israel, Jordan, Kuwait, Lebanon, Palestine, Saudi Arabia, United Arab Emirates and Qatar). Variability in the identified studies refers to the study design, objectives and the years of recruitment. Biological samples and data on environmental exposures were absent with the exception of limited studies (n = 44). This review revealed a sufficient number of available cohorts, however few have followed up children beyond the age of 2 years. Improved study designs focused on molecular and environmental data acquisition are required in a region that shares a set of unique characteristics in terms of landscape, climate, culture, and lifestyle. This review provides valuable information for planning future studies and set the grounds for collaborationswithin the MEA region and internationally.


2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Nina Wawro ◽  
Joachim Heinrich ◽  
Elisabeth Thiering ◽  
Jürgen Kratzsch ◽  
Beate Schaaf ◽  
...  

Allergy ◽  
2006 ◽  
Vol 61 (9) ◽  
pp. 1104-1111 ◽  
Author(s):  
T. Keil ◽  
M. Kulig ◽  
A. Simpson ◽  
A. Custovic ◽  
M. Wickman ◽  
...  

2021 ◽  
pp. 095269512199539
Author(s):  
Penny Tinkler ◽  
Resto Cruz ◽  
Laura Fenton

Birth cohort studies can be used not only to generate population-level quantitative data, but also to recompose persons. The crux is how we understand data and persons. Recomposition entails scavenging for various (including unrecognised) data. It foregrounds the perspective and subjectivity of survey participants, but without forgetting the partiality and incompleteness of the accounts that it may generate. Although interested in the singularity of individuals, it attends to the historical and relational embeddedness of personhood. It examines the multiple and complex temporalities that suffuse people’s lives, hence departing from linear notions of the life course. It implies involvement, as well as reflexivity, on the part of researchers. It embraces the heterogeneity and transformations over time of scientific archives and the interpretive possibilities, as well as incompleteness, of birth cohort studies data. Interested in the unfolding of lives over time, it also shines light on meaningful biographical moments.


2021 ◽  
pp. 100429
Author(s):  
Anne McMunn ◽  
Rebecca Lacey ◽  
Diana Worts ◽  
Diana Kuh ◽  
Peggy McDonough ◽  
...  

2021 ◽  
Vol 79 (1) ◽  
pp. 225-235
Author(s):  
Maya Arvidsson Rådestig ◽  
Johan Skoog ◽  
Henrik Zetterberg ◽  
Jürgen Kern ◽  
Anna Zettergren ◽  
...  

Background: We have previously shown that older adults with preclinical Alzheimer’s disease (AD) pathology in cerebrospinal fluid (CSF) had slightly worse performance in Mini-Mental State Examination (MMSE) than participants without preclinical AD pathology. Objective: We therefore aimed to compare performance on neurocognitive tests in a population-based sample of 70-year-olds with and without CSF AD pathology. Methods: The sample was derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden. Participants (n = 316, 70 years old) underwent comprehensive cognitive examinations, and CSF Aβ-42, Aβ-40, T-tau, and P-tau concentrations were measured. Participants were classified according to the ATN system, and according to their Clinical Dementia Rating (CDR) score. Cognitive performance was examined in the CSF amyloid, tau, and neurodegeneration (ATN) categories. Results: Among participants with CDR 0 (n = 259), those with amyloid (A+) and/or tau pathology (T+, N+) showed similar performance on most cognitive tests compared to participants with A-T-N-. Participants with A-T-N+ performed worse in memory (Supra span (p = 0.003), object Delayed (p = 0.042) and Immediate recall (p = 0.033)). Among participants with CDR 0.5 (n = 57), those with amyloid pathology (A+) scored worse in category fluency (p = 0.003). Conclusion: Cognitively normal participants with amyloid and/or tau pathology performed similarly to those without any biomarker evidence of preclinical AD in most cognitive domains, with the exception of slightly poorer memory performance in A-T-N+. Our study suggests that preclinical AD biomarkers are altered before cognitive decline.


1998 ◽  
Vol 73 (11) ◽  
pp. 1053-1061 ◽  
Author(s):  
Slavica K. Katusic ◽  
Robert C. Colligan ◽  
William J. Barbaresi ◽  
Daniel J. Schaid ◽  
Steven J. Jacobsen

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