Actions of head activator and head inhibitor during regeneration in hydra

1984 ◽  
Vol 26 (1-3) ◽  
pp. 91-96 ◽  
Author(s):  
Wolfgang Kemmner ◽  
H. Chica Schaller
Keyword(s):  
Head Activator ◽  
Head Inhibitor

scholarly journals Enzyme-linked immunosorbent assay for the neuropeptide 'head activator'

1984 ◽  
Vol 138 (2) ◽  
pp. 365-371 ◽  
Author(s):  
H. Chica SCHALLER ◽  
Heinz BODENMULLER ◽  
Beate ZACHMANN ◽  
Elke SCHILLING
Keyword(s):  
Immunosorbent Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Head Activator

Elevated levels of head activator in human brain tumors and in serum of patients with brain and other neurally derived tumors

1988 ◽  
Vol 6 (3) ◽  
pp. 251-258 ◽  
Author(s):  
H. C. Schaller ◽  
E. Schilling ◽  
L. Theilmann ◽  
H. Bodenm�ller ◽  
W. Sachsenheimer
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors ◽  
Head Activator

A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form

Development ◽  
1999 ◽  
Vol 126 (18) ◽  
pp. 4077-4086 ◽  
Author(s):  
W. Hampe ◽  
J. Urny ◽  
I. Franke ◽  
S.A. Hoffmeister-Ullerich ◽  
D. Herrmann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amino Acid ◽  
Transmembrane Domain ◽  
Binding Protein ◽  
Amino Acid Sequences ◽  
Secreted Protein ◽  
Specific Antibodies ◽  
Head Activator ◽  
Carboxy Terminal

The neuropeptide head activator plays an important role for proliferation and determination of stem cells in hydra. By affinity chromatography a 200 kDa head-activator binding protein, HAB, was isolated from the multiheaded mutant of Chlorohydra viridissima. Partial amino acid sequences were used to clone the HAB cDNA which coded for a receptor with a unique alignment of extracellular modules, a transmembrane domain, and a short carboxy-terminal cytoplasmic tail. A mammalian HAB homologue with identical alignment of these modules is expressed early in brain development. Specific antibodies revealed the presence of HAB in hydra as a transmembrane receptor, but also as secreted protein, both capable of binding head activator. Secretion of HAB during regeneration and expression in regions of high determination potential hint at a role for HAB in regulating the concentration and range of action of head activator.

scholarly journals The head activator is released from regenerating Hydra bound to a carrier molecule

1986 ◽  
Vol 5 (8) ◽  
pp. 1821-1824 ◽  
Author(s):  
H.C. Schaller ◽  
M. Roberge ◽  
B. Zachmann ◽  
S. Hoffmeister ◽  
E. Schilling ◽  
...  
Keyword(s):  
Carrier Molecule ◽  
Head Activator

scholarly journals Purification of a Head-Activator Receptor from Hydra

1997 ◽  
Vol 244 (3) ◽  
pp. 940-945 ◽  
Author(s):  
Inga Franke ◽  
Fritz Buck ◽  
Wolfgang Hampe
Keyword(s):  
Head Activator

scholarly journals Synthesis of a new neuropeptide, the head activator from hydra

FEBS Letters ◽  
1981 ◽  
Vol 131 (2) ◽  
pp. 317-321 ◽  
Author(s):  
C. Birr ◽  
B. Zachmann ◽  
H. Bodenmüller ◽  
H.C. Schaller
Keyword(s):  
Head Activator
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