Colocalization of the Dihydropyridine Receptor, the Plasma-Membrane Calcium ATPase Isoform 1 and the Sodium/Calcium Exchanger to the Junctional-Membrane Domain of Transverse Tubules of Rabbit Skeletal Muscle

1996 ◽  
Vol 237 (2) ◽  
pp. 483-488 ◽  
Author(s):  
Roberta Sacchetto ◽  
Alfredo Margreth ◽  
Michele Pelosi ◽  
Ernesto Carafoli
Keyword(s):  
Skeletal Muscle ◽  
Plasma Membrane ◽  
Dihydropyridine Receptor ◽  
Calcium Atpase ◽  
Rabbit Skeletal Muscle ◽  
Membrane Domain ◽  
Sodium Calcium Exchanger ◽  
Transverse Tubules ◽  
Plasma Membrane Calcium Atpase ◽  
Sodium Calcium

355 Plasma membrane calcium ATPase isoform 4 as a potential drug target for treatment during hypertrophy

2007 ◽  
Vol 6 (1) ◽  
pp. 81-81
Author(s):  
E CARTWRIGHT ◽  
F BAUDOIN ◽  
D OCEANDY ◽  
S PREHAR ◽  
M ZI ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Drug Target ◽  
Calcium Atpase ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Plasma Membrane Calcium Atpase

Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-atpase

Life Sciences ◽  
1999 ◽  
Vol 64 (14) ◽  
pp. 179-183 ◽  
Author(s):  
J-L. Horn ◽  
P.K. Janicki ◽  
J.J. Franks
Keyword(s):  
Plasma Membrane ◽  
Rat Brain ◽  
Calcium Atpase ◽  
Synaptic Plasma Membrane ◽  
Plasma Membrane Calcium Atpase ◽  
Fluorinated Ether

Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane

Biochemistry ◽  
1990 ◽  
Vol 29 (6) ◽  
pp. 1601-1607 ◽  
Author(s):  
Delyth M. Reid ◽  
Ute Friedel ◽  
Robert S. Molday ◽  
Neil J. Cook
Keyword(s):  
Plasma Membrane ◽  
Rod Outer Segments ◽  
Sodium Calcium Exchanger ◽  
Outer Segments ◽  
Sodium Calcium ◽  
Binding Glycoprotein

Plasma Membrane Calcium ATPase Gene Expression in Bovine Lens Epithelium

2000 ◽  
Vol 32 (2-3) ◽  
pp. 100-105 ◽  
Author(s):  
Lijun Bian ◽  
Junwen Zeng ◽  
Douglas Borchman ◽  
Christopher A. Paterson
Keyword(s):  
Gene Expression ◽  
Plasma Membrane ◽  
Calcium Atpase ◽  
Lens Epithelium ◽  
Plasma Membrane Calcium Atpase ◽  
Bovine Lens ◽  
Atpase Gene

scholarly journals A NOVEL ROLE OF PLASMA MEMBRANE CALCIUM ATPASE 4 AS A NEGATIVE-REGULATOR OF VEGF-INDUCED ANGIOGENESIS

Heart ◽  
2014 ◽  
Vol 100 (Suppl 4) ◽  
pp. A17.1-A17
Author(s):  
RR Baggott ◽  
A Alfranca ◽  
MD López-Maderuelo ◽  
TMA Mohamed ◽  
A Escolano ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Calcium Atpase ◽  
Negative Regulator ◽  
Plasma Membrane Calcium Atpase

scholarly journals Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4+ T-Cell Compartments

2021 ◽  
Vol 12 ◽  
Author(s):  
Maylin Merino-Wong ◽  
Barbara A. Niemeyer ◽  
Dalia Alansary
Keyword(s):  
Plasma Membrane ◽  
T Cell ◽  
Immune Responses ◽  
Chromatin Immunoprecipitation ◽  
Expression Patterns ◽  
Calcium Atpase ◽  
Cd4 T Cell ◽  
Plasma Membrane Calcium Atpase ◽  
Cell Compartments

Immune responses involve mobilization of T cells within naïve and memory compartments. Tightly regulated Ca2+ levels are essential for balanced immune outcomes. How Ca2+ contributes to regulating compartment stoichiometry is unknown. Here, we show that plasma membrane Ca2+ ATPase 4 (PMCA4) is differentially expressed in human CD4+ T compartments yielding distinct store operated Ca2+ entry (SOCE) profiles. Modulation of PMCA4 yielded a more prominent increase of SOCE in memory than in naïve CD4+ T cell. Interestingly, downregulation of PMCA4 reduced the effector compartment fraction and led to accumulation of cells in the naïve compartment. In silico analysis and chromatin immunoprecipitation point towards Ying Yang 1 (YY1) as a transcription factor regulating PMCA4 expression. Analyses of PMCA and YY1 expression patterns following activation and of PMCA promoter activity following downregulation of YY1 highlight repressive role of YY1 on PMCA expression. Our findings show that PMCA4 adapts Ca2+ levels to cellular requirements during effector and quiescent phases and thereby represent a potential target to intervene with the outcome of the immune response.

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