A whole genome scan to map QTL for milk production traits and somatic cell score in Canadian Holstein bulls

2009 ◽  
Vol 126 (3) ◽  
pp. 216-227 ◽  
Author(s):  
D. Kolbehdari ◽  
Z. Wang ◽  
J.R. Grant ◽  
B. Murdoch ◽  
A. Prasad ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Milk Production ◽  
Genome Scan ◽  
Somatic Cell Score ◽  
Whole Genome ◽  
Production Traits ◽  
Milk Production Traits ◽  
Whole Genome Scan ◽  
Holstein Bulls

167 Genetic and genomic estimation for somatic cell score in relation with milk production traits of Russian Holstein dairy cattle

2017 ◽  
Vol 95 (suppl_4) ◽  
pp. 82-83 ◽  
Author(s):  
A. A. Sermyagin ◽  
E. A. Gladyr' ◽  
A. A. Kharzhau ◽  
K. V. Plemyashov ◽  
E. N. Tyurenkova ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Somatic Cell ◽  
Milk Production ◽  
Somatic Cell Score ◽  
Production Traits ◽  
Milk Production Traits

scholarly journals L-selectin gene polymorphism and its association with clinical mastitis, somatic cell score, and milk production in Polish Holstein-Friesian cattle

2018 ◽  
Vol 63 (No. 7) ◽  
pp. 256-262 ◽  
Author(s):  
M. Dusza ◽  
J. Pokorska ◽  
J. Makulska ◽  
D. Kulaj ◽  
M. Cupial
Keyword(s):  
Somatic Cell ◽  
Milk Production ◽  
Milk Fat ◽  
Bacterial Infections ◽  
Clinical Mastitis ◽  
Somatic Cell Score ◽  
Production Traits ◽  
Milk Production Traits ◽  
Holstein Friesian ◽  
Friesian Cows

Bovine mastitis is a widespread disease of the mammary gland, highly contributing to the increase in veterinary costs in dairy industry. In the present study, the genetic polymorphism within bovine L-selectin gene was analysed and its impact on clinical mastitis occurrence, somatic cell score (SCS), and milk production traits in Polish Holstein-Friesian cows was examined. Polymorphism within L-selectin gene, molecule responsible for neutrophil attachment to endothelium, might have a potential role in immune response to bacterial infections and udder health. Two hundred and six Polish Holstein-Friesian cows were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Two single nucleotide polymorphisms mutations within the coding sequence of L-selectin gene were identified (c.165G>A and c.567C>T). The effect of c.165G>A and c.567C>T mutations on SCS was highly significant (P = 0.0019 and P = 0.0003, respectively). Strong associations (P ≤ 0.0001) were also observed between L-selectin polymorphism and milk production traits (milk yield, milk fat percentage, and milk protein percentage). However, the polymorphism in the analysed gene had no influence on the resistance or susceptibility of cows to clinical mastitis (only the tendency toward significance, P = 0.06 for c.567C>T mutation was found). Potential exploitation of the information on the identified associations in genetic selection needs to confirm the obtained results in further investigations.

scholarly journals Polymorphisms of the ACSL1 Gene Influence Milk Production Traits and Somatic Cell Score in Chinese Holstein Cows

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2282
Author(s):  
Yan Liang ◽  
Qisong Gao ◽  
Qiang Zhang ◽  
Abdelaziz Adam Idriss Arbab ◽  
Mingxun Li ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Milk Production ◽  
Somatic Cell Score ◽  
Holstein Cows ◽  
Production Traits ◽  
Milk Production Traits ◽  
Chinese Holstein ◽  
Chain Acyl ◽  
Chinese Holstein Cows ◽  
Long Chain

Improving the quality of milk is a challenge for zootechnicians and dairy farms across the globe. Long-chain acyl-CoA synthetase 1 (ACSL1) is a significant member of the long-chain acyl-CoA synthetase gene family. It is widely found in various organisms and influences the lactation performance of cows, including fat percentage, milk protein percentage etc. Our study was aimed to investigate the genetic effects of single nucleotide polymorphisms (SNPs) in ACSL1 on milk production traits. Twenty Chinese Holstein cows were randomly selected to extract DNA from their blood samples for PCR amplification and sequencing to identify SNPs of the bovine ACSL1 gene, and six SNPs (5’UTR-g.20523C>G, g.35446C>T, g.35651G>A, g.35827C>T, g.35941G>A and g.51472C>T) were discovered. Then, Holstein cow genotyping (n = 992) was performed by Sequenom MassARRAY based on former SNP information. Associations between SNPs and milk production traits and somatic cell score (SCS) were analyzed by the least-squares method. The results showed that SNP g.35827C>T was in high linkage disequilibrium with g.35941G>A. Significant associations were found between SNPs and test-day milk yield (TDMY), fat content (FC), protein content (PC) and SCS (p < 0.05). Among these SNPs, SNP 5’UTR-g.20523C>G showed an extremely significant effect on PC and SCS (p < 0.01). The SNP g.35446C>T showed a statistically significant effect on FC, PC, and SCS (p < 0.01), and also TDMY (p < 0.05). The SNP g.35651G>A had a statistically significant effect on PC (p < 0.01). The SNP g.35827C>T showed a highly significant effect on TDMY, FC, and SCS (p < 0.01) and significantly influenced PC (p < 0.05). Lastly, SNP g.51472C>T was significantly associated with TDMY, FC, and SCS (p < 0.05). In summary, the pleiotropic effects of bovine ACSL1 for milk production traits were found in this paper, but further investigation will be required on the intrinsic correlation to provide a theoretical basis for the research on molecular genetics of milk quality traits of Holstein cows.

scholarly journals Polymorphism in the promoter of <i>TLR4</i> gene by PCR-RFLP and its association with somatic cell score in Chinese Holstein

2014 ◽  
Vol 57 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Zhixiong Li ◽  
Huilin Zhang ◽  
Hongliang Wang ◽  
Ling Chen ◽  
Lijun Wang ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Milk Production ◽  
Somatic Cell Score ◽  
Upstream Region ◽  
Nucleotide Polymorphisms ◽  
Production Traits ◽  
Milk Production Traits ◽  
Chinese Holstein ◽  
Chinese Holstein Cows ◽  
Tlr4 Gene

Abstract. The objective of this study was to examine the effect of the polymorphism in the promoter of toll-like receptor 4 (TLR4) on mastitis and milk production traits. Two novel single nucleotide polymorphisms (SNPs) G-1539A before 5’-upstream region and G+265C in the 5’-UTR of TLR4 gene were detected, and genetic association analysis was applied on 421 Chinese Holstein cows. The statistical analysis indicated that two SNPs was significantly associated with 305 Days milk yield (P<0.05) and somatic cell score (SCS) respectively (P<0.01). Our results provide evidence that polymorphisms in the promoter of TLR4 are associated with milk production traits and SCS, and may be used as a possible candidate for marker-assisted selection and management in Holstein cattle breeding program.

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