INHIBITORY EFFECTS OF VERAPAMIL ON [3H]-ACETYLCHOLINE RELEASE IN THE CENTRAL NERVOUS SYSTEM OF SPRAGUE-DAWLEY RATS

1994 ◽  
Vol 21 (7) ◽  
pp. 527-531 ◽  
Author(s):  
Kazushi Tsuda ◽  
Seiko Tsuda ◽  
Menek Goldstein ◽  
Yoshiaki Masuyama
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acetylcholine Release ◽  
Sprague Dawley ◽  
Inhibitory Effects ◽  
Sprague Dawley Rats ◽  
The Central Nervous System

Episodic release of insulin by rat pancreas: effects of CNS and state of satiety

1988 ◽  
Vol 254 (3) ◽  
pp. E384-E388
Author(s):  
R. H. Safarik ◽  
R. M. Joy ◽  
D. L. Curry
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Insulin Release ◽  
Cycle Length ◽  
Sprague Dawley ◽  
Rat Pancreas ◽  
Sprague Dawley Rats ◽  
Metabolic Conditions ◽  
The Central Nervous System

This study reports that insulin is secreted in an episodic manner in rats and that the characteristics of its release can be modified by the central nervous system (CNS) and state of satiety. The pancreata of male Sprague-Dawley rats were perfused using the in situ brain-pancreas technique under urethan anesthesia. Episodic insulin release under non-fasted conditions was not altered by the presence or absence of CNS innervation to the pancreas. Under these conditions the interpeak period was 5.9 and 6 min, respectively, and cycle length was 3.7 and 4 min. However, perfusions that were performed following an overnight fast demonstrated that the CNS is capable of modulating episodic insulin release. After fasting, when comparing CNS-ablated with -intact preparations, the period was shortened from 5.2 to 4.1 min (P less than 0.05), and the number of episodes per 90-min perfusion increased from 16.0 to 19.0 (P less than 0.05) when the pancreas was innervated by the CNS. Additionally, the effect of fasting on denervated pancreata resulted in a shortening of the cycle length, which was prevented when the CNS was functional. These results demonstrate that episodic insulin release can be modified by metabolic conditions and are subject to mediation by the CNS.

scholarly journals Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system

RSC Advances ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 11902-11907 ◽  
Author(s):  
Annapurna Pamreddy ◽  
Sooraj Baijnath ◽  
Tricia Naicker ◽  
Sphamandla Ntshangase ◽  
Sipho Mdanda ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Central Nervous System ◽  
Nervous System ◽  
Mass Spectrometry Imaging ◽  
Sprague Dawley ◽  
System P ◽  
Sprague Dawley Rats ◽  
The Central Nervous System ◽  
The Brain

Bedaquiline (BDQ) was administered to healthy Sprague-Dawley rats in order to determine its localisation in the brain using mass spectrometry imaging (MSI). This study shows that BDQ has the potential for targeting TB reservoirs in the CNS.

Central catecholamine depletion, vasopressin, and blood pressure in the DOCA/NaCl rat

1983 ◽  
Vol 244 (6) ◽  
pp. H807-H813 ◽  
Author(s):  
T. Okuno ◽  
S. R. Winternitz ◽  
M. D. Lindheimer ◽  
S. Oparil
Keyword(s):  
Blood Pressure ◽  
Central Nervous System ◽  
Nervous System ◽  
Chemical Sympathectomy ◽  
Sprague Dawley ◽  
Paraventricular Nuclei ◽  
Sprague Dawley Rats ◽  
Intraventricular Injections ◽  
The Central Nervous System ◽  
6 Hydroxydopamine

To determine whether impaired arginine vasopressin (AVP) release occurs when DOCA-NaCl hypertension is prevented following chemical sympathectomy with 6-hydroxydopamine (6-OHDA), male Sprague-Dawley rats treated with intraventricular injections of 6-OHDA (250 micrograms X 2) or Merlis solution received deoxycorticosterone acetate (DOCA) implants (100 mg/kg) and drank 0.5% saline. Systolic blood pressure in the 6-OHDA-treated DOCA/NaCl group (139 +/- 4 mmHg) was lower (P less than 0.001) than in the Merlis-DOCA/NaCl group (183 +/- 7 mmHg). 6-OHDA treatment produced widespread catecholamine depletion throughout the central nervous system, including the supraoptic and paraventricular nuclei, the cells of which are known to produce AVP, but hypothalamic, pituitary, and plasma AVP levels were similar in both experimental groups, the latter values averaging 1.5–2 times those of controls. Both groups of rats suppressed AVP secretion appropriately when water loaded. Such suppression, however, had no effect on blood pressure in the hypertensive animals and, furthermore, administration of the AVP antagonist d(CH2)5Tyr(Me)AVP produced small decrements in mean blood pressure of both groups that were not significantly different from responses seen in control normotensive rats. These data demonstrate that 6-OHDA does not prevent DOCA-NaCl hypertension by decreasing AVP levels and suggest that AVP is not necessary for the maintenance of hypertension in this model.

scholarly journals Inhibitory Effects of the Essential Oil from SuHeXiang Wan on the Central Nervous System after Inhalation

2004 ◽  
Vol 27 (4) ◽  
pp. 515-519 ◽  
Author(s):  
Byung-Soo Koo ◽  
Seung-Il Lee ◽  
Jeoung-Hee Ha ◽  
Dong-Ung Lee
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Essential Oil ◽  
Inhibitory Effects ◽  
The Central Nervous System

scholarly journals A Study of the Effects of Vigabatrin on the Central Nervous System and Retina of Sprague Dawley and Lister-Hooded Rats

1987 ◽  
Vol 15 (2) ◽  
pp. 143-148 ◽  
Author(s):  
William H. Butler ◽  
Graham P. Ford ◽  
James W. Newberne
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sprague Dawley ◽  
The Central Nervous System
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