Reduced immunostaining for c-kit receptors in mucosal mast cells in inflammatory bowel disease

2007 ◽  
Vol 22 (12) ◽  
pp. 2338-2343 ◽  
Author(s):  
Ashkan Farhadi ◽  
Ali Keshavarzian ◽  
Jeremy Z Fields ◽  
Shriram Jakate ◽  
Maliha Shaikh ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cells ◽  
Bowel Disease ◽  
Mucosal Mast Cells ◽  
Inflammatory Bowel

scholarly journals Mucosal Mast Cells in Irritable Bowel Syndrome and Inflammatory Bowel Disease

2005 ◽  
Vol 48 (3-4) ◽  
pp. 163-164 ◽  
Author(s):  
Bilge Tunc ◽  
Levent Filik ◽  
Engin Altıntas ◽  
Nesrin Turhan ◽  
Aysel Ulker ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Bowel Disease ◽  
Mucosal Mast Cell ◽  
Cell Counts ◽  
Mucosal Mast Cells ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Even though exciting progresses have been until now, further studies are necessary to clearly understand the significance of MMC. Mast cells are thought to participate in the pathogenesis of inflammatory bowel disease and irritable bowel syndrome. However, their role in the pathogenesis remains unsettled. The specific aims of this study were to (1) examine mucosal mast cell counts in the cecum in patient with IBS, and IBD (2) compare MMC between the disease groups. We showed increased MMC count in IBS.

Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease

1996 ◽  
Vol 28 (1) ◽  
pp. 1-13 ◽  
Author(s):  
S.C. BISCHOFF ◽  
J. WEDEMEYER ◽  
A. HERRMANN ◽  
P.N. MEIER ◽  
C. TRAUTWEIN ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cells ◽  
Bowel Disease ◽  
Quantitative Assessment ◽  
Inflammatory Bowel

scholarly journals Mast Cells as Targets for the Therapy of Inflammatory Bowel Disease

1990 ◽  
Vol 4 (7) ◽  
pp. 285-288
Author(s):  
EY Bissonnette ◽  
RC Benyon ◽  
AD Befus
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cell ◽  
Mast Cells ◽  
Bowel Disease ◽  
Inflammatory Responses ◽  
Therapeutic Interventions ◽  
Cell Hyperplasia ◽  
Beneficial Effects ◽  
Inflammatory Bowel ◽  
Multiple Drugs

The etiology and pathogenesis of inflammatory bowel disease (IBD) is poorly understood. However, numerous studies have demonstrated that immunological and inflammatory responses are activated during this disease. A better understanding of these events will help identify appropriate therapeutic interventions. Mast cell hyperplasia is a prominent feature of inflamed intestinal tissue in IBD. Intestinal mast cells are heterogeneous and at least two populations are present in the human intestine. The authors' objective is to explore mast cell properties, activation and mediators that are involved in the induction, maintenance and perpetuation of inflammatory lesions in the intestine. Although some therapies used in IBD can modulate mast cell activities, whether these actions are important in the beneficial effects of the drugs is unknown. Future drug development targeted to the inhibition of mast cells might be of therapeutic value. However, a cascade of different cellular events are involved in IBD development. The complexity of the disease raises difficulties in the development of therapies. Multiple drugs, selective for different phases of the disease or acting on different cells, might be most appropriate, rather than a single, all-encompassing therapeutic agent.

scholarly journals Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs

2019 ◽  
Author(s):  
Andrés Espinoza-Zambrano ◽  
Carlos Manuel González
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cells ◽  
T Lymphocytes ◽  
Lamina Propria ◽  
Bowel Disease ◽  
B Lymphocyte ◽  
Gastrointestinal Symptoms ◽  
Intestinal Barrier Function ◽  
Mucosal Permeability ◽  
Inflammatory Bowel

AbstractInflammatory bowel disease (IBD) is a disease with recurring gastrointestinal symptoms. Lymphocytes and mast cells are proposed as important components in the immunopathology of IBD in dogs. Mast cells depend on degranulation, a process that compromises mucosal permeability and normal intestinal barrier function, which alters the normal inflammatory process by allowing recruitment of lymphocytes in dogs with IBD. In this study, T and B lymphocyte populations and mast cells were examined in situ in 39 intestinal samples of dogs affected by IBD, by immunohistochemistry. Both T lymphocytes and mast cells numbers were significantly higher in the lamina propria of the intestinal wall of dogs with IBD compared with control dogs. Out of the total number of mast cells detected by CD117 expression significantly less cells appear to be granulated according to granule staining with Toluidine Blue, suggesting that an important degranulation process takes place in IBD. Single and double immune staining for tryptase and chymase showed that mast cells can express only one or both enzymes. Tryptase positive cells were significantly higher in number that chymase positive and tryptase/chymase positive cells. T lymphocytes were concentrated mostly at the upper portion of the intestinal villi lamina propria while mast cells were distributed mainly among crypts. These results suggest that populations of T lymphocytes and mast cells play a role in the immunopathology and development of IBD in dogs, also these changes could be helpful as complementary indicators of canine IBD.

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