A unique role of dynein and nud family proteins in corticogenesis

2012 ◽  
Vol 32 (4) ◽  
pp. 432-439 ◽  
Author(s):  
Shiori Toba ◽  
Shinji Hirotsune
Keyword(s):  
Unique Role

Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space

2020 ◽  
Vol 64 (2) ◽  
pp. 251-261
Author(s):  
Jessica E. Fellmeth ◽  
Kim S. McKim
Keyword(s):  
Chromosome Segregation ◽  
New Technologies ◽  
Early Prophase ◽  
Unique Role ◽  
Kinetochore Assembly ◽  
M Phase ◽  
In Vivo Analysis ◽  
Meiosis I

Abstract While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique needs of homolog segregation during meiosis I (MI). CENP-C is a critical component of the centromere for kinetochore assembly in mitosis. Recent work, however, has highlighted the unique features of meiotic CENP-C. Centromere establishment and stability require CENP-C loading at the centromere for CENP-A function. Pre-meiotic loading of proteins necessary for homolog recombination as well as cohesion also rely on CENP-C, as do the main scaffolding components of the kinetochore. Much of this work relies on new technologies that enable in vivo analysis of meiosis like never before. Here, we strive to highlight the unique role of this highly conserved centromere protein that loads on to centromeres prior to M-phase onset, but continues to perform critical functions through chromosome segregation. CENP-C is not merely a structural link between the centromere and the kinetochore, but also a functional one joining the processes of early prophase homolog synapsis to late metaphase kinetochore assembly and signaling.

142-OR: Unique Role of the a4 Component for S6-Kinase Activity in Metabolic Regulation and Anti-apoptotic Effect in Brown Adipose Tissue

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 142-OR
Author(s):  
MASAJI SAKAGUCHI ◽  
SHOTA OKAGAWA ◽  
SAYAKA KITANO ◽  
TATSUYA KONDO ◽  
EIICHI ARAKI
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Regulation ◽  
Kinase Activity ◽  
S6 Kinase ◽  
Unique Role ◽  
Brown Adipose ◽  
Apoptotic Effect

The unique role of the social worker within the Hospital at Home care delivery team

2021 ◽  
pp. 1-15
Author(s):  
Helena Ross ◽  
Ryan Dritz ◽  
Barbara Morano ◽  
Sara Lubetsky ◽  
Pamela Saenger ◽  
...  
Keyword(s):  
Home Care ◽  
Social Worker ◽  
Care Delivery ◽  
Unique Role ◽  
The Social ◽  
Hospital At Home ◽  
At Home

The unique role of siderophore in marine-derived Aureobasidium pullulans HN6.2

BioMetals ◽  
2011 ◽  
Vol 25 (1) ◽  
pp. 219-230 ◽  
Author(s):  
Zhe Chi ◽  
Xing-Xing Wang ◽  
Zai-Chao Ma ◽  
Muhammad Aslam Buzdar ◽  
Zhen-Ming Chi
Keyword(s):  
Aureobasidium Pullulans ◽  
Unique Role

scholarly journals A unique role of endogenous visual-spatial attention in rapid processing of multiple targets.

2011 ◽  
Vol 37 (4) ◽  
pp. 1065-1073 ◽  
Author(s):  
Emmanuel Guzman-Martinez ◽  
Marcia Grabowecky ◽  
German Palafox ◽  
Satoru Suzuki
Keyword(s):  
Spatial Attention ◽  
Multiple Targets ◽  
Unique Role ◽  
Visual Spatial Attention ◽  
Visual Spatial ◽  
Rapid Processing

Role of EP2 and EP3 PGE2receptors in control of murine renal hemodynamics

2001 ◽  
Vol 280 (1) ◽  
pp. H327-H333 ◽  
Author(s):  
Laurent P. Audoly ◽  
Xiaoping Ruan ◽  
Victoria A. Wagner ◽  
Jennifer L. Goulet ◽  
Stephen L. Tilley ◽  
...  
Keyword(s):  
Renal Artery ◽  
Vascular Reactivity ◽  
Renal Hemodynamics ◽  
Receptor Subtypes ◽  
Male Mice ◽  
Unique Role ◽  
Arterial Blood ◽  
Renal Vascular

The kidney plays a central role in long-term regulation of arterial blood pressure and salt and water homeostasis. This is achieved in part by the local actions of paracrine and autacoid mediators such as the arachidonic acid-prostanoid system. The present study tested the role of specific PGE2 E-prostanoid (EP) receptors in the regulation of renal hemodynamics and vascular reactivity to PGE2. Specifically, we determined the extent to which the EP2 and EP3 receptor subtypes mediate the actions of PGE2 on renal vascular tone. Renal blood flow (RBF) was measured by ultrasonic flowmetry, whereas vasoactive agents were injected directly into the renal artery of male mice. Studies were performed on two independent mouse lines lacking either EP2or EP3 (−/−) receptors and the results were compared with wild-type controls (+/+). Our results do not support a unique role of the EP2 receptor in regulating overall renal hemodynamics. Baseline renal hemodynamics in EP2−/− mice [RBF EP2−/−: 5.3 ± 0.8 ml · min−1 · 100 g kidney wt−1; renal vascular resistance (RVR) 19.7 ± 3.6 mmHg · ml−1 · min · g kidney wt] did not differ statistically from control mice (RBF +/+: 4.0 ± 0.5 ml · min−1 · 100 g kidney wt−1; RVR +/+: 25.4 ± 4.9 mmHg · ml−1 · min · 100 g kidney wt−1). This was also the case for the peak RBF increase after local PGE2 (500 ng) injection into the renal artery (EP2−/−: 116 ± 4 vs. +/+: 112 ± 2% baseline RBF). In contrast, we found that the absence of EP3receptors in EP3−/− mice caused a significant increase (43%) in basal RBF (7.9 ± 0.8 ml · min−1 · g kidney wt−1, P < 0.05 vs. +/+) and a significant decrease (41%) in resting RVR (11.6 ± 1.4 mmHg · ml−1 · min · g kidney wt−1, P < 0.05 vs. +/+). Local administration of 500 ng of PGE2 into the renal artery caused more pronounced renal vasodilation in EP3−/− mice (128 ± 2% of basal RBF, P < 0.05 vs. +/+). We conclude that EP3 receptors mediate vasoconstriction in the kidney of male mice and its actions are tonically active in the basal state. Furthermore, EP3receptors are capable of buffering PGE2-mediated renal vasodilation.

Sign in / Sign up

Export Citation Format

Share Document