Inhibition of the Nociceptive R2 Blink Reflex after Supraorbital or Index Finger Stimulation is Normal in Migraine Without Aura Between Attacks

Cephalalgia ◽  
2007 ◽  
Vol 27 (7) ◽  
pp. 803-808 ◽  
Author(s):  
G Coppola ◽  
L Di Clemente ◽  
A Fumal ◽  
D Magis ◽  
V De Pasqua ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Migraine Without Aura ◽  
Index Finger ◽  
Sensory System ◽  
Blink Reflex ◽  
Electrical Shock ◽  
Recovery Curve ◽  
Recovery Curves

In order to explore possible interictal brainstem dysfunctions in migraine, we have studied the R2 component of the nociceptive specific blink reflex (nBR) after conditioning by supraorbital or index finger stimuli in 14 untreated migraine without aura patients (MO) between attacks and in 15 healthy volunteers. We determined the R2 recovery curve at increasing inter-stimulus intervals between 50 and 600 ms. The nBR was conditioned by a paired supraorbital stimulus and, in another session, by an ipsilateral electrical shock delivered to the index finger. The R2 nBR recovery curves were normal in MO patients for both the supraorbital and peripheral conditioning. These results do not favour persistent interictal sensitization in the spinal trigeminal sensory system. They also suggest that the control exerted by descending brainstem pathways on medullary R2 interneurones is normal in migraine between attacks.

Verbal learning deficits following severe head injury: heterogeneity in recovery over 1 year

1991 ◽  
Vol 75 (Supplement) ◽  
pp. S50-S58 ◽  
Author(s):  
Ronald M. Ruff ◽  
David Young ◽  
Theresa Gautille ◽  
Lawrence F. Marshall ◽  
Jeff Barth ◽  
...  
Keyword(s):  
Memory Performance ◽  
Verbal Learning ◽  
Data Bank ◽  
Learning Deficits ◽  
Content Type ◽  
Recovery Curve ◽  
Recovery Curves ◽  
Head Injured ◽  
Injured Patients ◽  
Case Basis

✓ A total of 40 severely head-injured patients were selected from the Traumatic Coma Data Bank, supported by the National Institute of Neurological Disorders and Stroke, to analyze the recovery of verbal learning across baseline and 6- and 12-month evaluations postinjury. During the initial 6 months, the group demonstrated marked recovery, followed by an absence of improvement over the latter part of the year. Analysis of this recovery curve on a case by case basis revealed three recovery subtypes: namely, a flat curve, a peak-drop curve, or an improvement curve. These three subtypes proved to have concurrent validity when compared with another memory test. Adding 19 new patients to the sample cross-validated the subtypes. However, the memory performance of the 59 patients was dissociated from other neuropsychological tests which showed recovery at more equivalent rates across the subtypes. Analysis of the demographic and neurological characteristics disclosed that the group with a peak-drop recovery curve was less well educated and the group with a flat curve demonstrated a trend toward higher levels of hypoxia. Moreover, the three subgroups were rated by their relatives to have equivalent levels of depression at baseline and at 6 months, but only the improved subgroup demonstrated reduced depression at 1 year. The clinical relevancy of these differential recovery curves is discussed.

Spatial Contrast Sensitivity of Migraine Patients Without Aura

Cephalalgia ◽  
2002 ◽  
Vol 22 (2) ◽  
pp. 142-145 ◽  
Author(s):  
K Benedek ◽  
J Tajti ◽  
M Janáky ◽  
L Vécsei ◽  
G Benedek
Keyword(s):  
Healthy Volunteers ◽  
Contrast Sensitivity ◽  
Migraine Without Aura ◽  
Marked Decrease ◽  
Primary Headache ◽  
Visual Pathway ◽  
Control Subjects ◽  
Spatial Frequencies ◽  
Spatial Contrast Sensitivity ◽  
Visual Disturbances

Visual disturbances are frequent symptoms in migraine. Since there is a possibility of separate damage in the magno- or parvo-cellular visual pathway in migraine patients, we performed a study including the measurement of static and dynamic spatial contrast sensitivity on 15 patients suffering from migraine without aura under photopic and scotopic conditions. Fifteen healthy volunteers without primary headache served as controls. The results revealed a marked decrease in contrast sensitivity at low spatial frequencies in the migraine patients. Spatial contrast sensitivity demonstrated some lateralization, as the sensitivity to low spatial frequencies obtained through separate eyes showed significantly larger side-differences in migraine patients than in control subjects. These findings suggest that the mechanisms responsible for vision at low spatial frequencies are impaired in migraine patients. This might indicate impaired function of the magnocellular pathways in this condition.

Blink Reflex R2 Recovery Curves in Patients with Facial Palsy within Ten Days after Onset

ORL ◽  
2005 ◽  
Vol 67 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Naoki Toda ◽  
Katsuhiko Nakamura ◽  
Noriaki Takeda
Keyword(s):  
Facial Palsy ◽  
Blink Reflex ◽  
Recovery Curves

Nociceptive-specific blink reflex and glyceryl trinitrate infusion in healthy volunteers

2003 ◽  
Vol 10 (3) ◽  
pp. 295-299 ◽  
Author(s):  
F. Kowacs ◽  
N. J. Giffin ◽  
N. Putzki ◽  
P. J. Goadsby ◽  
H. Kaube
Keyword(s):  
Glyceryl Trinitrate ◽  
Healthy Volunteers ◽  
Blink Reflex

Blink reflex recovery curves in blepharospasm, torticollis spasmodica, and hemifacial spasm

1996 ◽  
Vol 19 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Job L.A. Eekhof ◽  
Majid Aramideh ◽  
Lo J. Bour ◽  
Anton A.J. Hilgevoord ◽  
Hans D. Speelman ◽  
...  
Keyword(s):  
Hemifacial Spasm ◽  
Blink Reflex ◽  
Recovery Curves

scholarly journals PROCESSING OF OIL WELL PRESSURE RECOVERY CURVES

2019 ◽  
pp. 18-20
Author(s):  
Abasova Inara Afrail
Keyword(s):  
Numerical Simulation ◽  
Mathematical Model ◽  
Pressure Recovery ◽  
Oil Well ◽  
Recovery Curve ◽  
Recovery Curves ◽  
Reservoir Permeability ◽  
Curve Change ◽  
Industry Conditions

In the article the development of a mathematical model describing the PRC is studied on the base of pressure recovery curve method.Detailed processing of the pressure recovery curve made it possible to determine the deterioration of reservoir permeability in many wells. Here two methods are considered - stationary (steady conditions of selection) and non- stationary.The article proves that the use of these methods allows to develop a mathematical model to increase the determination of this task.On the base of numerical simulation, the following facts had impact on the results of the pressure recovery curve: well shutdown time, taking into account the initial transition section, taking into account curve change section before well shutdown.The study of variable factors impact on the results is carried out by interval estimation.The mathematical model describing the pressure recovery curve is local and changes its structures. This model can be used in industry conditions.

Assessment of Blink Reflex in Genetic Generalized Epilepsy Patients With Eyelid Myoclonia

2016 ◽  
Vol 48 (2) ◽  
pp. 118-122 ◽  
Author(s):  
Güneş Altıokka-Uzun ◽  
Esme Ekizoğlu ◽  
Elif Kocasoy-Orhan ◽  
Nerses Bebek ◽  
Candan Gürses ◽  
...  
Keyword(s):  
Occipital Cortex ◽  
Blink Reflex ◽  
Juvenile Myoclonic Epilepsy ◽  
Control Groups ◽  
Rare Type ◽  
Recovery Curves ◽  
Generalized Seizures ◽  
And Gender ◽  
Generalized Epilepsy ◽  
International League

Eyelid myoclonia (EM) with or without absences are a rare type of generalized seizures associated with a variety of epilepsy syndromes with an unknown pathophysiology. The aim of this study was to investigate the possible contribution of the brainstem structures in this underrecognized special type of seizures. Sixteen consecutive patients with EM, diagnosed with genetic generalized epilepsy (GGE) according to International League Against Epilepsy 2010 criteria were included. Brainstem excitabilities were examined by blink reflex (BR) studies. The results of BR studies in GGE patients with EM were statistically compared with 2 control groups; namely age- and gender-matched healthy volunteers and juvenile myoclonic epilepsy (JME) patients without any absences and using similar antiepileptic drugs. There were no statistical differences between the thresholds of the BR studies and the BR recovery curves in terms of amplitudes and areas of healthy subjects, JME patients and GGE patients with EM. Our findings do not support a profound interictal hyperexcitability in the BR-related brainstem structures of the GGE patients with EM. It can be considered that EM may be associated with excitability changes of the occipital cortex and other cortical areas.

scholarly journals Modeling recovery curves with application to prostatectomy

Biostatistics ◽  
2018 ◽  
Vol 20 (4) ◽  
pp. 549-564 ◽  
Author(s):  
Fulton Wang ◽  
Cynthia Rudin ◽  
Tyler H Mccormick ◽  
John L Gore
Keyword(s):  
Decision Aid ◽  
Medical Literature ◽  
Medical Decision ◽  
Clinical Settings ◽  
Curve Shape ◽  
Sharp Drop ◽  
Recovery Curve ◽  
Recovery Curves ◽  
Pre Treatment ◽  
Scalar Time Series

Summary In many clinical settings, a patient outcome takes the form of a scalar time series with a recovery curve shape, which is characterized by a sharp drop due to a disruptive event (e.g., surgery) and subsequent monotonic smooth rise towards an asymptotic level not exceeding the pre-event value. We propose a Bayesian model that predicts recovery curves based on information available before the disruptive event. A recovery curve of interest is the quantified sexual function of prostate cancer patients after prostatectomy surgery. We illustrate the utility of our model as a pre-treatment medical decision aid, producing personalized predictions that are both interpretable and accurate. We uncover covariate relationships that agree with and supplement that in existing medical literature.

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