Migraine and Left-Handedness are not Associated. A New Case—Control Study and Meta-Analysis

To investigate the possible association between migraine and left-handedness, we enrolled 100 patients with a diagnosis of migraine according to the International Headache Society diagnostic criteria and 100 age- and sex-matched control subjects into a case—control study. Handedness was determined by the Edinburgh Handedness Inventory. There was no significant difference in the frequency or grade of left-handedness between the two groups. Additionally, we pooled our data with those from five similar studies, which did not alter the result. Thus, neither our study nor the meta-analysis support Geschwind and Behan's hypothesis of an association between migraine and left-handedness.

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Correlation of FGFR2 rs2981582 polymorphisms with susceptibility to breast cancer: a case-control study in a Chinese population

Journal of International Medical Research ◽

10.1177/0300060519869058 ◽

2019 ◽

Vol 47 (10) ◽

pp. 4753-4763

Author(s):

Jin Shu ◽

Xuelian Hui ◽

Xin Zheng ◽

Juan Zhao ◽

Zhaochen Xu ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Estrogen Receptor Status ◽

Meta Analysis ◽

Case Control ◽

Plasma Dna ◽

Study Results ◽

Significant Difference ◽

The Relationship ◽

Control Study

Objective Breast cancer (BC) is a common malignancy among women worldwide. Fibroblast growth factor receptor 2 (FGFR2) rs2981582 is reported to play a vital role in BC development. However, the relationship between them remains unclear. Methods Ninety-five patients and 140 healthy controls were enrolled in the study. Plasma DNA was genotyped by the MassARRAY method. A meta-analysis was conducted to clarify the effect of FGFR2 polymorphism on BC risk. Results Our case-control study results revealed a significant difference in CC, TC, and TT genotypes between patients and controls. Logistic regression analysis showed that TT and TC genotype and the dominant mode were significantly correlated with BC development [odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.050–2.27; OR = 1.81, 95% CI: 1.24–2.73; OR = 2.15, 95% CI: 1.25–5.31, respectively], even after adjusting for age, body weight, drinking, smoking, and estrogen receptor status. A meta-analysis of 15 studies showed significant differences among the dominant, recessive, heterozygote, and homozygote models between patients and controls. Conclusions Our results showed an association of FGFR2 rs2981582 polymorphism with BC in an Asian population. However, a more comprehensive study of the relationship between the polymorphism and BC is still needed.

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Association of the UCP polymorphisms with susceptibility to obesity: case-control study and meta-analysis

Endocrine Abstracts ◽

10.1530/endoabs.35.p402 ◽

2014 ◽

Author(s):

Bianca Souza ◽

Leticia Brondani ◽

Tais Assmann ◽

Ana Paula Boucas ◽

Andrea Carla Bauer ◽

...

Keyword(s):

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Control Study

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Ocular Comorbidities in Rosacea: A Case-Control Study Based on Seven Institutions

Journal of Clinical Medicine ◽

10.3390/jcm10132897 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2897

Author(s):

Yu Ri Woo ◽

Minah Cho ◽

Hyun Jeong Ju ◽

Jung Min Bae ◽

Sang Hyun Cho ◽

...

Keyword(s):

Dry Eye ◽

Case Control Study ◽

Matched Control ◽

Case Control ◽

Dry Eye Syndrome ◽

Data Set ◽

Ocular Symptoms ◽

Inflammatory Dermatosis ◽

Control Study ◽

Surface Changes

Rosacea is a facial inflammatory dermatosis that is linked with various systemic illnesses. With regards to the eye, rosacea patients have been described to manifest ocular surface changes, such as blepharitis and conjunctivitis. However, studies that examine the association of rosacea with a wider array of ocular diseases are limited. Thus, our aim was to identify the range of ocular comorbidities in the Korean patient population and create a reference data set. A multi-institutional, case-control study was conducted, where 12,936 rosacea patients and an equal number of sex- and age-matched control subjects were extracted over a 12-year period. We were able to discover a notable association between rosacea and blepharitis (adjusted odds ratio (aOR) 3.44; 95% confidence interval, 2.71–4.36, p < 0.001), conjunctivitis (aOR 1.65; 95% CI, 1.50–1.82, p < 0.001), glaucoma (aOR 1.93; 95% CI, 1.70–2.20, p < 0.001), dry eye syndrome (aOR 1.89; 95% CI, 1.70–2.09, p < 0.001), and chalazion (aOR 3.26; 95% CI, 1.41–7.57, p = 0.006) from logistic regression analysis. Female subjects and individuals younger than 50 exclusively showed higher odds for chalazion. Our study suggests that ocular comorbidities (i.e., glaucoma, dry eye syndrome, and chalazion as well as blepharitis and conjunctivitis) are more prevalent among Koreans with rosacea. Clinicians should proactively check ocular symptoms in rosacea and employ joint care with an ophthalmologist in cases of need.

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Case–Control Study and Meta-Analysis of the Association Between LIPG rs9958947 SNP and Stroke Risk

Journal of Molecular Neuroscience ◽

10.1007/s12031-021-01795-w ◽

2021 ◽

Author(s):

Kok Yeow Phneh ◽

Eric Tzyy Jiann Chong ◽

Syahiskandar Sybil Shah ◽

Yuen Kang Chia ◽

Dayang Maryama Bte Awang Daud ◽

...

Keyword(s):

Stroke Risk ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Control Study

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Risk factors associated with subacromial pain in young athletes: A case control study

Journal of Back and Musculoskeletal Rehabilitation ◽

10.3233/bmr-191683 ◽

2021 ◽

pp. 1-9

Author(s):

Zoran Z. Sarcevic ◽

Andreja P. Tepavcevic

Keyword(s):

Logistic Regression ◽

Case Control Study ◽

Case Control ◽

Sternoclavicular Joint ◽

Pectoralis Major ◽

Young Athletes ◽

Serratus Anterior ◽

Significant Difference ◽

Lower Trapezius ◽

Control Study

BACKGROUND: Subacromial pain (SAP) is a common complaint of young athletes, independently of the sport engaged. The prevalence of SAP in some sports is up to 50%. OBJECTIVE: The study was aimed to investigate some new factors possibly associated to subacromial pain in young athletes. The factors considered were the grade of tightness of the clavicular portion of the pectoralis major, dysfunction of the sternoclavicular joint, and serratus anterior and lower trapezius strength. METHODS: This case-control study included 82 young athletes 9–15 years, 41 with the symptoms of SAP and 41 controls. All participants self-reported whether they had subacromial pain. In addition, Hawkins–Kennedy Test was performed to all the participants to evaluate the subacromial pressure. Main outcome measures were the grade of tightness of the clavicular portion of the pectoralis major, dysfunction of the sternoclavicular joint, and serratus anterior and lower trapezius strength. The grade of tightness of the clavicular portion of the pectoralis major and the dysfunction of the sternoclavicular joint were measured with an inclinometer. Serratus anterior and lower trapezius strength were measured by a handheld dynamometer with external belt-fixation. The data were analyzed using t-test for independent samples, Mann-Whitney U test, contingency coefficients and a stepwise binary logistic regression. RESULTS: Significant statistical difference was observed in the grade of tightness of the clavicular portion of the pectoralis major and in the variable representing the physiological functioning of the sternoclavicular joint, between the cases and the controls. There was no significant difference in serratus anterior and lower trapezius strength between the cases and the controls. Logistic regression analysis showed that the variable representing the physiological functioning of the sternoclavicular joint and the grade of shortening of the clavicular portion of the pectoralis major were good predictors for presence of SAP. CONCLUSIONS: A strong association was determined between subacromial pain in young athletes, clavicular portion of pectoralis major tightness and the dysfunction of the sternoclavicular joint.

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Genetic association of TOLLIP gene polymorphisms and HIV infection: a case-control study

BMC Infectious Diseases ◽

10.1186/s12879-021-06303-4 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ming-Gui Wang ◽

Jing Wang ◽

Jian-Qing He

Keyword(s):

Hiv Infection ◽

Gene Polymorphisms ◽

Case Control Study ◽

Binary Logistic Regression ◽

Case Control ◽

Additive Models ◽

Chinese Han ◽

Interacting Protein ◽

Control Study ◽

Age And Sex

Abstract Background Previous studies have indicated that host genetic factors play an essential role in immunity to human immunodeficiency virus (HIV) infection. We aimed to investigate the association between the toll-interacting protein (TOLLIP) and mannose-binding lectin 2 (MBL2) genes and HIV infection susceptibility among Chinese Han patients. Methods This is a case-control study. A total of 435 HIV-infected patients and 1013 seronegative healthy individuals were recruited. DNA was extracted from whole blood. Two SNPs in the MBL2 gene (rs7096206 and rs1800450) and three SNPs in the TOLLIP gene (rs5743899, rs3750920, and rs5743867) were selected and genotyped using a SNPscan Kit (Cat#: G0104, Genesky Biotechnologies Inc., Shanghai, China). Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using unconditional binary logistic regression. Results A significant association between the minor alleles rs5743899 (C allele) and rs5743867 (G allele) in the TOLLIP gene and susceptibility to HIV infection was found in this study after adjusting for age and sex (Pa = 0.011 and < 0.001, respectively). The rs5743867 in the TOLLIP gene was significantly associated with the risk of HIV infection in dominant, recessive, and additive models when adjusted for age and sex (Pa < 0.05). No significant association was found between MBL2 gene polymorphisms and HIV infection. Conclusion Our study found a statistically significant association between the two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population.

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