Comparison of aerobic exercise capacity and muscle strength in overweight women with and without polycystic ovary syndrome

In order to explore the possible treatment mechanism of metformin on the local ovarian cell tissue of rats with polycystic ovary syndrome (PCOS), 35 female clean sterile rats were selected as the research objects in this study, and randomly divided a PCOS model group (PCOS MG) (25 rats) and a control group (CG) (10 rats). After the modelling was completed, 5 rats were randomly selected to evaluate the modelling effect. When the success rate was higher than 80%, the remaining model rats were divided into two groups randomly, namely the (PCOS MG) (10 rats) and the treatment group (TG) (10 rats). Hematoxylin-eosin (HE) staining was performed on ovarian tissue of the rat, and the ovarian tissue structure was observed under light microscope. Immunohistochemistry was used to detect the distribution and expression levels of tumour necrosis factor-α (TNF-α), insulin-like growth factor-I (IGF-I), and connective tissue growth factor (CTGF) on the ovaries of rats in each group. It was found by observing the vaginal smear under the microscope that the rats in the (PCOS MG) had lost the regular estrous cycle, suggesting that there was no ovulation. The expression levels of TNF-α and CTGF in rats in the (PCOS MG) were greatly higher than those in the CG (P < 0.05); compared with the (PCOS MG), the expression levels of TNF-α and CTGF in the TG were decreased observably (P < 0.05). IGF-I was mainly expressed in granulosa cells (GCs) and follicular membrane cells (FMCs) of the ovarian tissue. The expression level of IGF-I in ovarian GCs in rats in the (PCOS MG) was significantly higher than that in the CG (P < 0.05). The expression level of IGF-I in GCs in the TG was lower significantly than that in the (PCOS MG) (P < 0.05). By comparing with rats in the CG, the rats in the (PCOS MG) had obviously decreased Actinobacteria and Betaproteobacteria in the intestinal tract, and the proportion of Firmicutes in the intestine was significantly increased; the amount of butyric acid in the faeces of rats with aerobic exercise was obviously higher than that in the (PCOS MG), because exercise increased the proportion of intestinal butyric acid-producing bacteria. Conclusion: metformin combined with aerobic exercise can treat the PCOS by regulating serum hormone levels and the expression levels of TNF-α, IGF-I, and CTGF.

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Exenatide Reduces Body Weight but Not Hyperandrogenemia in Overweight Women with Polycystic Ovary Syndrome

10.1210/endo-meetings.2011.part2.p32.p2-242 ◽

2011 ◽

pp. P2-242-P2-242

Author(s):

Alison J Dawson ◽

Thozhukat Sathyapalan ◽

Eric S Kilpatrick ◽

Stephen L Atkin

Keyword(s):

Body Weight ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Overweight Women

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A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome

Journal of Functional Morphology and Kinesiology ◽

10.3390/jfmk5020035 ◽

2020 ◽

Vol 5 (2) ◽

pp. 35

Author(s):

Grei Shele ◽

Jessica Genkil ◽

Diana Speelman

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Aerobic Exercise ◽

Exercise Intervention ◽

Polycystic Ovary ◽

Healthy Weight ◽

Ovary Syndrome ◽

Exercise Interventions ◽

The Impact ◽

Androgen Levels

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is characterized by menstrual irregularity and elevated serum androgens, and is often accompanied by insulin resistance. The etiology of PCOS is unknown. Lifestyle interventions and weight loss, where appropriate, remain first-line treatments for women with PCOS. Regular physical activity is recommended for women with PCOS to maintain a healthy weight and cardiovascular fitness. Purpose: To review the evidence for the impact of various exercise interventions on hormone levels in women with PCOS. Methods: A systematic review of original studies indexed in PubMed that utilized an exercise intervention in women with PCOS and reported hormone values pre- and post-intervention. Studies in which the effects of the exercise intervention could be determined were included. Results: Vigorous aerobic exercise improves insulin measures in women with PCOS. Resistance or strength training may improve androgen levels, though additional studies are warranted. Studies with yoga are limited but suggest improvements in androgens. Limited information is available on the impact of exercise on adipokines and anti-Müllerian hormone, warranting further investigation. Conclusions: Recommended guidelines for women with PCOS include vigorous aerobic exercise and resistance training to improve measures of insulin sensitivity and androgen levels.

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Metformin Decreases the Adipokine Vaspin in Overweight Women With Polycystic Ovary Syndrome Concomitant With Improvement in Insulin Sensitivity and a Decrease in Insulin Resistance

Diabetes ◽

10.2337/db08-0127 ◽

2008 ◽

Vol 57 (6) ◽

pp. 1501-1507 ◽

Cited By ~ 98

Author(s):

B. K. Tan ◽

D. Heutling ◽

J. Chen ◽

S. Farhatullah ◽

R. Adya ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Overweight Women

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Continuous versus intermittent aerobic exercise in the improvement of quality of life for women with polycystic ovary syndrome: A randomized controlled trial

Journal of Health Psychology ◽

10.1177/1359105319869806 ◽

2019 ◽

pp. 135910531986980 ◽

Cited By ~ 3

Author(s):

Victor Barbosa Ribeiro ◽

Iris Palma Lopes ◽

Rosana Maria dos Reis ◽

Rafael Costa Silva ◽

Maria Célia Mendes ◽

...

Keyword(s):

Quality Of Life ◽

Polycystic Ovary Syndrome ◽

Aerobic Exercise ◽

Aerobic Training ◽

Polycystic Ovary ◽

Control Group ◽

Ovary Syndrome ◽

Testosterone Levels ◽

Randomized Controlled

Polycystic ovary syndrome predisposes alterations which contribute to the reduction of quality of life. This randomized controlled clinical trial study was to evaluate the effect of two protocols of aerobic exercise on quality of life in women with polycystic ovary syndrome. Women were allocated to three groups: continuous aerobic training ( n = 28), intermittent aerobic training ( n = 29), and control group (no training; n = 30). Testosterone levels, body composition indices, and quality of life were assessed at baseline and after 16 weeks of intervention. Both protocols were effective to improve testosterone levels, anthropometric indices, and quality of life in polycystic ovary syndrome women. Thus, these protocols should be included in the clinical environment to improve clinical parameters psychological, biological and social health to this population.

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