scholarly journals Docosahexaenoic acid disruptsin vitroamyloid β1-40fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer’s disease model rats

2008 ◽  
Vol 107 (6) ◽  
pp. 1634-1646 ◽  
Author(s):  
Michio Hashimoto ◽  
Hossain Md Shahdat ◽  
Shinji Yamashita ◽  
Masanori Katakura ◽  
Yoko Tanabe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Docosahexaenoic Acid ◽  
Disease Model

Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin

Neuroscience ◽  
2011 ◽  
Vol 197 ◽  
pp. 358-368 ◽  
Author(s):  
T. Kurata ◽  
K. Miyazaki ◽  
M. Kozuki ◽  
N. Morimoto ◽  
Y. Ohta ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Disease Model

scholarly journals Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats

2002 ◽  
Vol 81 (5) ◽  
pp. 1084-1091 ◽  
Author(s):  
Michio Hashimoto ◽  
Shahdat Hossain ◽  
Toshio Shimada ◽  
Kozo Sugioka ◽  
Hiroshi Yamasaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Docosahexaenoic Acid ◽  
Disease Model ◽  
Learning Ability

scholarly journals Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lishu Duan ◽  
Mufeng Hu ◽  
Joseph A. Tamm ◽  
Yelena Y. Grinberg ◽  
Fang Shen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Disease Model ◽  
Mitochondrial Morphology ◽  
Individual Gene ◽  
Human Genes ◽  
Future Drug ◽  
Tau Aggregation

AbstractAlzheimer’s disease (AD) is a common neurodegenerative disease with poor prognosis. New options for drug discovery targets are needed. We developed an imaging based arrayed CRISPR method to interrogate the human genome for modulation of in vitro correlates of AD features, and used this to assess 1525 human genes related to tau aggregation, autophagy and mitochondria. This work revealed (I) a network of tau aggregation modulators including the NF-κB pathway and inflammatory signaling, (II) a correlation between mitochondrial morphology, respiratory function and transcriptomics, (III) machine learning predicted novel roles of genes and pathways in autophagic processes and (IV) individual gene function inferences and interactions among biological processes via multi-feature clustering. These studies provide a platform to interrogate underexplored aspects of AD biology and offer several specific hypotheses for future drug discovery efforts.

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