L-Norvaline improves spatial memory in Alzheimer’s disease model mice via escalation of neuroplasticity-associated gene expression, activation of neuroprotective pathways, and reduction of microglial density.

2018 ◽  
Author(s):  
Baruh Polis
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spatial Memory ◽  
Disease Model

scholarly journals Nutrigenomic Studies on the Ameliorative Effect of Enzyme-Digested Phycocyanin in Alzheimer’s Disease Model Mice

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4431
Author(s):  
Yasuyuki Imai ◽  
Yurino Koseki ◽  
Makoto Hirano ◽  
Shin Nakamura
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Oral Administration ◽  
Expression Patterns ◽  
Disease Model ◽  
Neuroprotective Effects ◽  
Aberrant Expression ◽  
Ameliorative Effect

Alzheimer’s disease (AD) is the most common form of dementia, and the cognitive impairments associated with this degenerative disease seriously affect daily life. Nutraceuticals for the prevention or delay of AD are urgently needed. It has been increasingly observed that phycocyanin (PC) exerts neuroprotective effects. AD model mice intracerebroventricularly injected with amyloid beta-peptide 25–35 (Aβ25–35) at 10 nmol/head displayed significant cognitive impairment in the spontaneous alternation test. Cognitive impairment was significantly ameliorated in mice treated with 750 mg/kg of enzyme-digested (ED) PC by daily oral administration for 22 consecutive days. Application of DNA microarray data on hippocampal gene expression to nutrigenomics studies revealed that oral EDPC counteracted the aberrant expression of 35 genes, including Prnp, Cct4, Vegfd (Figf), Map9 (Mtap9), Pik3cg, Zfand5, Endog, and Hbq1a. These results suggest that oral administration of EDPC ameliorated cognitive impairment in AD model mice by maintaining and/or restoring normal gene expression patterns in the hippocampus.

The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model

2006 ◽  
Vol 21 (6) ◽  
pp. 611-619 ◽  
Author(s):  
Rita U. Ostrovskaya ◽  
Marina A. Gruden ◽  
Natalya A. Bobkova ◽  
Robert D. E. Sewell ◽  
Tatyana A. Gudasheva ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spatial Memory ◽  
Disease Model

Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer’s Disease Model

2016 ◽  
Vol 55 (3) ◽  
pp. 1273-1283 ◽  
Author(s):  
Jesus Mendiola-Precoma ◽  
Karla Padilla ◽  
Alfredo Rodríguez-Cruz ◽  
Laura C. Berumen ◽  
Ricardo Miledi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Brain ◽  
Purinergic Receptor ◽  
Receptor Gene ◽  
Disease Model ◽  
Induced Changes ◽  
Receptor Gene Expression
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