Comparing the Health Utilities Index Mark 3 (HUI3) with the Short Form-36 Preference-Based SF-6D in Chronic Kidney Disease

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients’ lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life—Short Form (KDQOL-SFTM) version 1.3 and CKD Symptom Index—Sri Lanka. Socio-demographic, disease-related, and anthropometric variables were also investigated. The mean age of patients was 61.87 (SD 11.31), while 69.2% were male. The mean glomerular filtration rate was 28.17 (SD 14.03) mL/min/1.73 min2, and 70.8% were anemic. Bone/joint pain was the most experienced symptom while the median number of symptoms reported by patients was 5 (IQR 3–7). The mean symptom burden, physical component summary, mental component summary, and kidney-disease-specific component scores were 12.71 (SD 10.45), 68.63 (SD 19.58), 78.53 (SD 18.78), and 81.57 (SD 5.86), respectively. Age was found to be a significant predictor of HRQOL, while hemoglobin level and being a farmer were significant predictors of symptom burden. Our data indicate that CKDu patients in all stages experience at least one symptom affecting all aspects of HRQOL.

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The impact of comorbid chronic kidney disease and diabetes on health-related quality-of-life: a 12-year community cohort study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa031 ◽

2020 ◽

Cited By ~ 2

Author(s):

Melanie L R Wyld ◽

Rachael L Morton ◽

Leyla Aouad ◽

Dianna Magliano ◽

Kevan R Polkinghorne ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Short Form ◽

Mixed Effect ◽

Linear Mixed Effect ◽

Prospective Longitudinal ◽

The Impact

Abstract Background Quality-of-life is an essential outcome for clinical care. Both chronic kidney disease (CKD) and diabetes have been associated with poorer quality-of-life. The combined impact of having both diseases is less well understood. As diabetes is the most common cause of CKD, it is imperative that we deepen our understanding of their joint impact. Methods This was a prospective, longitudinal cohort study of community-based Australians aged ≥25 years who participated in the Australian Diabetes, Obesity and Lifestyle study. Quality-of-life was measured by physical component summary (PCS) and mental component summary sub-scores of the Short Form (36) Health Survey. Univariate and multivariate linear mixed effect regressions were performed. Results Of the 11 081 participants with quality-of-life measurements at baseline, 1112 had CKD, 1001 had diabetes and of these 271 had both. Of the 1112 with CKD 421 had Stage 1, 314 had Stage 2, 346 had Stage 3 and 31 had Stages 4/5. Adjusted linear mixed effect models showed baseline PCS was lower for those with both CKD and diabetes compared with either disease alone (P < 0.001). Longitudinal analysis demonstrated a more rapid decline in PCS in those with both diseases. Conclusions The combination of CKD and diabetes has a powerful adverse impact on quality-of-life, and participants with both diseases had significantly poorer quality-of-life than those with one condition.

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Comparing Short Form 6D, Standard Gamble, and Health Utilities Index Mark 2 and Mark 3 utility scores: Results from total hip arthroplasty patients

Quality of Life Research ◽

10.1007/s11136-004-6189-2 ◽

2004 ◽

Vol 13 (10) ◽

pp. 1659-1670 ◽

Cited By ~ 59

Author(s):

David Feeny ◽

Lieling Wu ◽

Ken Eng

Keyword(s):

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Standard Gamble ◽

Short Form ◽

Health Utilities Index ◽

Health Utilities ◽

Total Hip ◽

Utility Scores

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Arabic translation, adaptation, and validation of the kidney disease quality of life short-form 36

Saudi Journal of Kidney Diseases and Transplantation ◽

10.4103/1319-2442.275476 ◽

2019 ◽

Vol 30 (6) ◽

pp. 1322

Author(s):

Sarra Elamin ◽

AbdelbagiH E. Elbasher ◽

ShimaE E. Ali ◽

Hasan Abu-Aisha

Keyword(s):

Quality Of Life ◽

Kidney Disease ◽

Short Form ◽

Arabic Translation ◽

Short Form 36

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Validity and internal consistency of EQ-5D-3L quality of life tool among pre-dialysis patients with chronic kidney disease in Sri Lanka, a lower middle-income country

10.1101/524603 ◽

2019 ◽

Author(s):

Sameera Senanayake ◽

PKB Mahesh ◽

Nalika Gunawardena ◽

Nicholas Graves ◽

Sanjeewa Kularatna

Keyword(s):

Chronic Kidney Disease ◽

Psychological Distress ◽

Sri Lanka ◽

Kidney Disease ◽

Internal Consistency ◽

Short Form ◽

Economic Evaluations ◽

Cronbach Alpha ◽

Sf 36 ◽

D 20

AbstractObjectiveEQ-5D-3L is a generic QOL tool used mainly in economic evaluations. Burden of Chronic Kidney Disease (CKD) is rising in Sri Lanka. Assessing the validity of generic QOL tools creates new opportunities of their utilization among patients with CKD.MethodsA cross-sectional study was conducted among 1036 CKD patients, selected using the simple random sampling technique. The validity was tested with six a-priori hypotheses. These included construct validity assessments, evaluating convergent validity and performing known group comparisons. EQ-5D-3L, Short Form-36 (SF-36), Center for Epidemiological Studies Depression Scale (CES-D-20) and General Health Questionnaire-12 (GHQ-12) were used to assess QOL, presence of depression and psychological distress respectively. Internal consistency of the whole tool and when each item is removed was assessed by Cronbach alpha.ResultsThe response rate was 99.2%. Majority of participants were males (n=646,62.4%) in the age category of 41-60 (n=530; 51.2%). Most were in either stage 4 or 5 of CKD (n=646,75.1%). The summary measures of SF-36, positively and significantly correlated with the EQ-5D-3L index and VAS scores (p<0.001). EQ-5D-3L QOL scores were significantly different between the group with depression and without as measured by CES-D-20 (p<0.001). Assessed using GHQ-12, similar significance was detected between the group with psychological distress and without (p<0.001). The Cronbach alpha was 0.834 and when each item was removed, ranged from 0.782 to 0.832.ConclusionEQ-5D-3L is a valid generic QOL tool with satisfactory internal consistency to be used among CKD patients in the pre-dialysis stage.

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