The impact of comorbid chronic kidney disease and diabetes on health-related quality-of-life: a 12-year community cohort study

Abstract Background Quality-of-life is an essential outcome for clinical care. Both chronic kidney disease (CKD) and diabetes have been associated with poorer quality-of-life. The combined impact of having both diseases is less well understood. As diabetes is the most common cause of CKD, it is imperative that we deepen our understanding of their joint impact. Methods This was a prospective, longitudinal cohort study of community-based Australians aged ≥25 years who participated in the Australian Diabetes, Obesity and Lifestyle study. Quality-of-life was measured by physical component summary (PCS) and mental component summary sub-scores of the Short Form (36) Health Survey. Univariate and multivariate linear mixed effect regressions were performed. Results Of the 11 081 participants with quality-of-life measurements at baseline, 1112 had CKD, 1001 had diabetes and of these 271 had both. Of the 1112 with CKD 421 had Stage 1, 314 had Stage 2, 346 had Stage 3 and 31 had Stages 4/5. Adjusted linear mixed effect models showed baseline PCS was lower for those with both CKD and diabetes compared with either disease alone (P < 0.001). Longitudinal analysis demonstrated a more rapid decline in PCS in those with both diseases. Conclusions The combination of CKD and diabetes has a powerful adverse impact on quality-of-life, and participants with both diseases had significantly poorer quality-of-life than those with one condition.

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Chronic kidney disease-associated pruritus significantly impacts on quality of life of patients on haemodialysis and associates with increased levels of serum calcium and phosphorus

Postgraduate Medical Journal ◽

10.1136/postgradmedj-2020-139688 ◽

2021 ◽

pp. postgradmedj-2020-139688

Author(s):

Qiuyu Xie ◽

Nan Hu ◽

Yuqing Chen

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Linear Regression ◽

Multiple Linear Regression ◽

Short Form ◽

Record System ◽

Calcium And Phosphorus ◽

The Impact

Purpose of the studyChronic kidney disease-associated pruritus (CKD-aP) is common among patients on maintenance haemodialysis (HD). We performed a study to explore the clinical features of patients with CKD-aP and evaluate the impact of CKD-aP on the quality of life of HD patients.Study designPatients who were receiving regular HD over 3 months were recruited. Quality of life was quantified by the Short Form-12 (SF-12) questionnaire. Pruritus was evaluated by the 5D-Itch Scale. Demographic characteristics and biochemical indicators were obtained from the medical record system. Multiple linear regression was used to assess the association between pruritus and targeting factors. The relationship between the scores on the 5D-Itch Scale and SF-12 was analysed using multiple linear regression, adjusted for other factors, to demonstrate the impact of CKD-aP on the quality of life of HD patients.ResultsIn total, 269 out of 301 (89.4%) patients accomplished all investigations. The prevalence of CKD-aP in our cohort was 40.9%. Age (B=0.339, p=0.042), treatment with haemoperfusion (B=1.853, p=0.018), and serum level of calcium (B=3.566, p=0.008) and phosphorus (B=1.543, p=0.002) were independently associated with pruritus. Score on the 5D-Itch Scale negatively impacted on physical component summary (B=−0.778, p<0.001) and mental component summary (B=−0.675, p<0.001).ConclusionsPruritus significantly aggravates the quality of life of HD patients. Irregularity in the metabolism of calcium and phosphorus may partially explain the mechanism of CKD-aP. More effective treatment of CKD-MBD may help to prevent pruritus and improve patients’ mental and physical health conditions.

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The impact of progressive chronic kidney disease on health-related quality-of-life: a 12-year community cohort study

Quality of Life Research ◽

10.1007/s11136-019-02173-1 ◽

2019 ◽

Vol 28 (8) ◽

pp. 2081-2090 ◽

Cited By ~ 5

Author(s):

Melanie L. R. Wyld ◽

Rachael L. Morton ◽

Phil Clayton ◽

Muh Geot Wong ◽

Meg Jardine ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Impact

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Anemia among Chinese patients with chronic kidney disease and its association with quality of life - results from the Chinese cohort study of chronic kidney disease (C-STRIDE)

BMC Nephrology ◽

10.1186/s12882-021-02247-8 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Yan Shen ◽

◽

Jinwei Wang ◽

Jing Yuan ◽

Li Yang ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Systematic Investigation ◽

Chinese Patients ◽

Cross Sectional ◽

Five Dimensions ◽

Anemia Treatment

Abstract Background Anemia is one of the common complications in patients with chronic kidney disease (CKD). However, there is no systematic investigation on the prevalence of anemia in CKD patients and its relationship with the quality of life in China. Methods The data for this study comes from baseline data from the Chinese Chronic Kidney Disease Cohort Study (C-STRIDE), which recruited predialysis CKD patients in China. The kidney disease quality of life summary (KDQOL-TM) was used to assess health-related quality of life (HRQoL). Use linear regression model to estimate the relationship between hemoglobin level and quality of life. Results A total of 2921 patients were included in this study. The adjusted prevalence of hemoglobin (Hb) less than 100 g/L was 10.3% (95% confidence interval [CI]: 9.9,11.4%), and showed an increased trend through reduced eGFR levels from 4.0% (95%CI:2.3,5.9%) in the 45-60 ml/min/1.73m2 group to 23.4% (95%CI:20.5,26.2%) in the 15–29 ml/min/1.73m2 group. The prevalence of anti-anemia treatment was 34.0% (95%CI: 28.7,39.3%) and it is shown by reducing eGFR levels from 15.8% (95%CI:0,36.7%) in the 45-60 ml/min/1.73m2 group to 38.2% (95%CI: 30.7,45.2%) in the 15–29 ml/min/1.73m2 group. All five dimensions of the KDQOL scores in patients with CKD decreased as hemoglobin declined. After multivariable adjustments,the degrees of decrease became somewhat blunted. For example, compared with hemoglobin of ≥130 g/L, regression coefficients in the hemoglobin of < 100 g/L were − 0.047(95%CI: − 0.049,-0.045) for Symptoms and Problems(S), − 0.047(95%CI: − 0.049,-0.044) for Effects of the Kidney Disease(E), − 0.207(95%CI: − 0.212,-0.203) for Burden of the Kidney Disease(B), − 0.112(95%CI: − 0.115,-0.109) for SF-12 Physical Functioning (PCS), − 0.295(95%CI: − 0.299, -0.292) for SF-12 Mental Functioning (MCS), respectively. Conclusions In our cross-sectional analysis of patients with CKD in China, prevalence of both anemia and anti-anemia treatment increased with decreased eGFR. In addition, anemia was associated with reduced HRQoL.

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The impact of axial spondyloarthritis on quality of life (QoL): a comparison with the impact of moderate to end-stage chronic kidney disease on QoL

Quality of Life Research ◽

10.1007/s11136-018-1900-x ◽

2018 ◽

Vol 27 (9) ◽

pp. 2321-2327 ◽

Cited By ~ 5

Author(s):

Yu Heng Kwan ◽

Warren Fong ◽

Priscilla How ◽

Hwee-Lin Wee ◽

Ying Ying Leung ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Axial Spondyloarthritis ◽

End Stage ◽

The Impact

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Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17114041 ◽

2020 ◽

Vol 17 (11) ◽

pp. 4041 ◽

Cited By ~ 1

Author(s):

Hansani Madushika Abeywickrama ◽

Swarna Wimalasiri ◽

Yu Koyama ◽

Mieko Uchiyama ◽

Utako Shimizu ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Sri Lanka ◽

Kidney Disease ◽

Short Form ◽

Symptom Burden ◽

Symptom Index ◽

The Mean ◽

Uncertain Etiology

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients’ lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life—Short Form (KDQOL-SFTM) version 1.3 and CKD Symptom Index—Sri Lanka. Socio-demographic, disease-related, and anthropometric variables were also investigated. The mean age of patients was 61.87 (SD 11.31), while 69.2% were male. The mean glomerular filtration rate was 28.17 (SD 14.03) mL/min/1.73 min2, and 70.8% were anemic. Bone/joint pain was the most experienced symptom while the median number of symptoms reported by patients was 5 (IQR 3–7). The mean symptom burden, physical component summary, mental component summary, and kidney-disease-specific component scores were 12.71 (SD 10.45), 68.63 (SD 19.58), 78.53 (SD 18.78), and 81.57 (SD 5.86), respectively. Age was found to be a significant predictor of HRQOL, while hemoglobin level and being a farmer were significant predictors of symptom burden. Our data indicate that CKDu patients in all stages experience at least one symptom affecting all aspects of HRQOL.

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Impact of Medium Cut-Off Dialyzers on Patient-Reported Outcomes: COREXH Registry

Blood Purification ◽

10.1159/000508803 ◽

2020 ◽

pp. 1-9

Author(s):

Juan Carlos Alarcon ◽

Alfonso Bunch ◽

Freddy Ardila ◽

Eduardo Zuñiga ◽

Jasmin I. Vesga ◽

...

Keyword(s):

Quality Of Life ◽

Kidney Disease ◽

Repeated Measures ◽

Patient Reported Outcomes ◽

Short Form ◽

High Flux ◽

Middle Molecules ◽

Patient Reported ◽

The Impact

Introduction: A new generation of hemodialysis (HD) membranes called medium cut-off (MCO) membranes possesses enhanced capacities for middle molecule clearance, which have been associated with adverse outcomes in this population. These improvements could potentially positively impact patient-reported outcomes (PROs). Objective: The objective of this study was to evaluate the impact of MCO membranes on PROs in a cohort of HD patients in Colombia. Methods: This was a prospective, multicenter, observational cohort study of 992 patients from 12 renal clinics in Colombia who were switched from high-flux HD to MCO therapy and observed for 12 months. Changes in Kidney Disease Quality of Life 36-Item Short Form Survey (KDQoL-SF36) domains, Dialysis Symptom Index (DSI), and restless legs syndrome (RLS) 12 months after switching to MCO membranes were compared with time on high-flux membranes. Repeated measures of ANOVA were used to evaluate changes in KDQoL-SF36 scores; severity scoring was used to assess DSI changes over time; Cochran’s Q test was used to evaluate changes in frequency of diagnostic criteria of RLS. Results: During 12 months of follow-up, 3 of 5 KDQoL-SF36 domains improved compared with baseline: symptoms (p < 0.0001), effects of kidney disease (p < 0.0001), and burden of kidney disease (p < 0.001). The proportion of patients diagnosed with RLS significantly decreased from 22.1% at baseline to 10% at 12 months (p < 0.0001). No significant differences in the number of symptoms (DSI, p = 0.1) were observed, although their severity decreased (p = 0.009). Conclusions: In conventional HD patients, the expanded clearance of large middle molecules with MCO-HD membranes was associated with higher health-related quality of life scores and a decrease in the prevalence of RLS.

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Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Health and Quality of Life Outcomes ◽

10.1186/s12955-020-01519-5 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Li Chen ◽

◽

Jinwei Wang ◽

Xiaoyan Huang ◽

Fang Wang ◽

...

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Health Related Quality ◽

Related Quality ◽

Chinese Cohort ◽

Health Related

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Association between health related quality of life and progression of chronic kidney disease

Scientific Reports ◽

10.1038/s41598-019-56102-w ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Tae Ryom Oh ◽

Hong Sang Choi ◽

Chang Seong Kim ◽

Eun Hui Bae ◽

Yun Kyu Oh ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Summary Score ◽

Health Related Quality ◽

Ckd Progression ◽

Related Quality ◽

Health Related

AbstractThe impact of health-related quality of life (HRQOL) on outcomes remains unclear in chronic kidney disease (CKD) patients despite its importance in socioeconomic aspects and individual health. We aim to identify the relationship between HRQOL and progression of CKD in pre-dialysis patients. A total 1622 patients with CKD were analyzed in the KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease, a prospective cohort study. CKD progression was defined as one or more of the following: initiation of dialysis or transplantation, a two-fold increase in baseline serum creatinine levels, or a 50% decline in the estimated glomerular filtration rate during the follow-up period. The group with CKD progression had lower scores of HRQOL than the group without CKD progression. A fully adjusted Cox proportional hazard ratio model showed that each low baseline physical and mental component summary score was associated with a higher risk of CKD progression. In Kaplan-Meier survival analysis using propensity score matched data, only low physical component summary scores showed statistical significance with CKD progression. Our study highlights low physical component summary score for an important prognostic factor of CKD progression. Risk-modification interventions for high-risk patients may provide benefits to individuals.

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The quality of life of chronic kidney disease patients with hypertension treated with angiotensin system-related agents

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.3573 ◽

2020 ◽

Vol 11 (4) ◽

pp. 6633-6639

Author(s):

Mohammed Salim KT ◽

Saravanakumar RT ◽

Dilip C ◽

Amrutha KP

Keyword(s):

Quality Of Life ◽

Blood Pressure ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Antihypertensive Drugs ◽

Angiotensin Receptor Blockers ◽

Converting Enzyme Inhibitors ◽

Angiotensin System ◽

The Impact

The chronic kidney disease (CKD) co-exist with hypertension in approximately 80 to 85 per cent of patients. The CKD stages can be defined by glomerular filtration rate (GFR), and the deterioration of kidney function or reduction in GFR has observed in those with uncontrolled blood pressure (BP). We had conducted a prospective study to analyse the impact of the angiotensin system-related agents on the quality of life of CKD patients with hypertension. The SF-36 questionnaire, direct patients interview and medical records were the sources for retrieval of information. We observed that male patients were more prone to CKD than female. Hypertension was the primary (77.8%) aetiology behind the incidence of CKD. The angiotensin-converting enzyme inhibitors (ACEI) was responsible for very low (58%) and low (44%) health disabilities to the patients. In contrast, the angiotensin receptor blockers (ARB) even though it has a limited adverse effect, the patients complained of medium (9%) and high disabilities than the ACEIs. The discontinuation of the antihypertensive drugs by the CKD patients was almost negligible (3.4%). The study concludes that a balanced diet and reasonable blood pressure control is essential to prevent the progression of CKD and to improve the quality of life.

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