Long-Term Observation of Retinal Electrical Activity in Dialyzed and Renal Transplantation Patients

Sexual life and fertility are compromised in end stage kidney disease both in men and in women. Successful renal transplantation may rapidly recover fertility in the vast majority of patients. Pregnancy modifies anatomical and functional aspects in the kidney and represents a risk of sensitization that may cause acute rejection. Independently from the risks for the graft, pregnancy in kidney transplant may cause preeclampsia, gestational diabetes, preterm delivery, and low birth weight. The nephrologist has a fundamental role in correct counseling, in a correct evaluation of the mother conditions, and in establishing a correct time lapse between transplantation and conception. Additionally, careful attention must be given to the antirejection therapy, avoiding drugs that could be dangerous to the newborn. Due to the possibility of medical complications during pregnancy, a correct follow-up should be exerted. Even if pregnancy in transplant is considered a high risk one, several data and studies document that in the majority of patients, the long-term follow-up and outcomes for the graft may be similar to that of non-pregnant women.

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Angiogenesis Inhibitors as Anti-Cancer Therapy Following Renal Transplantation: A Case Report and Review of the Literature

Current Oncology ◽

10.3390/curroncol28010064 ◽

2021 ◽

Vol 28 (1) ◽

pp. 661-670

Author(s):

Lawrence Kasherman ◽

Jeffrey Doi ◽

Katherine Karakasis ◽

Jeffrey Schiff ◽

Abhijat Kitchlu ◽

...

Keyword(s):

Renal Transplantation ◽

Organ Transplant ◽

Angiogenesis Inhibitors ◽

Solid Organ ◽

Transplant Recipients ◽

Immunosuppressive Medication ◽

Increased Risk ◽

Anti Cancer ◽

Solid Organ Transplant Recipients

Solid organ transplant recipients on long-term immunosuppressive medication are at increased risk of developing malignancy, and treatment of advanced cancers with angiogenesis inhibitors in this context has not been widely studied. We present a case of recurrent high-grade serous ovarian carcinoma treated with paclitaxel and bevacizumab in the context of prior renal transplantation where the patient responded well to treatment with controlled toxicities, discussing the potential for increased rates of adverse events and drug interactions in this select population.

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Phenotype of the Aging-Dependent Spontaneous Onset of Hearing Loss in DBA/2 Mice

Veterinary Sciences ◽

10.3390/vetsci8030049 ◽

2021 ◽

Vol 8 (3) ◽

pp. 49

Author(s):

Min-Soo Seo ◽

Byeonghyeon Lee ◽

Kyung-Ku Kang ◽

Soo-Eun Sung ◽

Joo-Hee Choi ◽

...

Keyword(s):

Hearing Loss ◽

Early Stage ◽

Auditory Brainstem ◽

Dependent Manner ◽

Intrinsic Properties ◽

Hearing Ability ◽

Brainstem Response ◽

Long Term Observation ◽

Spontaneous Onset

DBA/2 mice are a well-known animal model for hearing loss developed due to intrinsic properties of these animals. However, results on the phenotype of hearing loss in DBA/2 mice have been mainly reported at an early stage in mice aged ≤7 weeks. Instead, the present study evaluated the hearing ability at 5, 13, and 34 weeks of age using DBA/2korl mice. Auditory brainstem response test was performed at 8–32 KHz at 5, 13, and 34 weeks of age, and hearing loss was confirmed to be induced in a time-dependent manner. In addition, histopathological evaluation at the same age confirmed the morphological damage of the cochlea. The findings presented herein are the results of the long-term observation of the phenotype of hearing loss in DBA/2 mice and can be useful in studies related to aging-dependent hearing loss.

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Posterior Uveal Effusion after Cataract Surgery

Case Reports in Ophthalmology ◽

10.1159/000510390 ◽

2021 ◽

pp. 62-67

Author(s):

Annegret Abaza ◽

Özlem Dikmetas ◽

Irmingard Neuhann ◽

Faik Gelisken

Keyword(s):

Cataract Surgery ◽

Corticosteroid Therapy ◽

Anterior Segment ◽

Subretinal Fluid ◽

Posterior Pole ◽

Functional Improvement ◽

Long Term Observation ◽

The Right ◽

Uveal Effusion

We report a case of posterior uveal effusion (UE) with a long-term follow-up that has occurred following cataract surgery. A 64-year-old woman presented with diminished vision of the right eye (RE) 3 weeks after an uneventful phacoemulsification and intraocular lens implantation. Complete ophthalmic examination including fluorescein angiography (FA), indocyanine green angiography (ICGA), echography and optical coherence tomography (OCT) were performed. Best corrected visual acuity (BCVA) of the RE was 20/50. Anterior segment and intraocular pressure were unremarkable. OCT revealed prominent folds of the choroid and retina, subretinal fluid and darkening of the choroid with reduced visibility of the choroidal vessels and the scleral border. The left eye (LE) was unremarkable. BCVA of the LE was: 20/20. After topical anti-inflammatory and systemic corticosteroid therapy for 5 months, no morphological change of the macula was seen. The patient was observed without any treatment. Forty-three months after the cataract surgery and 38 months after cessation of the corticosteroid therapy, OCT revealed a normal macular morphology and the BCVA improved to 20/25. Even though rare, UE at the posterior pole may occur after modern cataract surgery. OCT examination is a reliable tool in monitoring the macular morphology. Since morphological and functional improvement can be seen in long-term, observation may be considered for some cases of posterior UE with resistance to the therapy.

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