scholarly journals Pharmacological Properties, Central Nervous System Effects, and Potential Therapeutic Applications of Atipamezole, a Selective α2-Adrenoceptor Antagonist

2006 ◽  
Vol 11 (3) ◽  
pp. 273-288 ◽  
Author(s):  
Antti Pertovaara ◽  
Antti Haapalinna ◽  
Jouni Sirviö ◽  
Raimo Virtanen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pharmacological Properties ◽  
Therapeutic Applications ◽  
Adrenoceptor Antagonist ◽  
Α2 Adrenoceptor

scholarly journals Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

2008 ◽  
Vol 6 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Agata Siwek ◽  
Monika Wujec ◽  
Maria Dobosz ◽  
Ewa Jagiełło-Wójtowicz ◽  
Anna Chodkowska ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Carboxylic Acid ◽  
Acid Hydrazide ◽  
Pharmacological Properties ◽  
Pharmacological Effects ◽  
Carboxylic Acid Hydrazide ◽  
Wide Range ◽  
The Central Nervous System

AbstractBy the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses.

scholarly journals Chemical and Pharmacological Aspects of the Genus Cecropia

2011 ◽  
Vol 6 (6) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Geison M. Costa ◽  
Eloir P. Schenkel ◽  
Flávio H. Reginatto
Keyword(s):  
Blood Pressure ◽  
Central Nervous System ◽  
Nervous System ◽  
Latin America ◽  
Heart Disease ◽  
Chemical Composition ◽  
Pharmacological Properties ◽  
Nervous System Activity ◽  
Therapeutic Uses ◽  
Central Nervous System Activity

The Cecropia genus consists of about 60 species distributed throughout Latin America, mostly in Brazil. These species are widely used in traditional medicine to treat cough, asthma, bronchitis, high blood pressure, inflammation, heart disease, and as a diuretic. In recent years, there has been an increase in research on Cecropia species, with several phytochemical and pharmacological reports. Concerning its chemical composition, C-glycosylflavonoids and proanthocyanidins have been described as the main constituents of C. glaziovii, C. hololeuca and C. pachystachya, while terpenoids and steroids have been reported in several species, including C. adenopus and C. pachystachya. Among the pharmacological properties described for the genus, the most frequently reported are hypoglycemic activity for C. obtusifolia and C. peltata, and hypotensive and central nervous system activity for C. glaziovii. The present review compiles the information available on this genus because of its ethnopharmacological relevance and the potential therapeutic uses of these species.

scholarly journals Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

2009 ◽  
Vol 30 (1) ◽  
pp. 15-35 ◽  
Author(s):  
Jason S Weinstein ◽  
Csanad G Varallyay ◽  
Edit Dosa ◽  
Seymur Gahramanov ◽  
Bronwyn Hamilton ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Therapeutic Applications

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood–brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.

Sign in / Sign up

Export Citation Format

Share Document