Acute Hyperglycemia Induced by Oral Glucose Loading Suppresses Coronary Microcirculation on Transthoracic Doppler Echocardiography in Healthy Young Adults

2006 ◽  
Vol 23 (10) ◽  
pp. 829-834 ◽  
Author(s):  
Kohei Fujimoto ◽  
Takeshi Hozumi ◽  
Hiroyuki Watanabe ◽  
Kotaro Tokai ◽  
Kenei Shimada ◽  
...  
Keyword(s):  
Young Adults ◽  
Doppler Echocardiography ◽  
Coronary Microcirculation ◽  
Oral Glucose ◽  
Transthoracic Doppler Echocardiography ◽  
Acute Hyperglycemia ◽  
Glucose Loading

Two cases of unstable angina with proximal coronary artery stenosis diagnosed by transthoracic Doppler echocardiography

Choonpa Igaku ◽  
2008 ◽  
Vol 35 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Yuko SUGIYAMA ◽  
Masayo SUZUKI ◽  
Keiichi HIRANO ◽  
Keijirou NAKAMURA ◽  
Mao TAKAHASHI ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Unstable Angina ◽  
Doppler Echocardiography ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Transthoracic Doppler Echocardiography ◽  
Proximal Coronary Artery

Induction of renal phosphoenolpyruvate carboxykinase mRNA: suppressive effect of glucose

1989 ◽  
Vol 257 (1) ◽  
pp. F145-F151
Author(s):  
A. S. Pollock
Keyword(s):  
Metabolic Acidosis ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Suppressive Effect ◽  
Oral Glucose ◽  
Prolonged Fasting ◽  
Glucose Loading ◽  
Glucose Administration ◽  
Liver And Kidney ◽  
Gluconeogenic Enzyme ◽  
Effect Of Glucose

The mRNA for the important gluconeogenic enzyme phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32) is expressed in liver and kidney. In the kidney, acidosis is a unique and potent stimulus, whereas insulin, the major counterregulatory hormone of gluconeogenesis, has no effect. In this study, we find that oral glucose administration to rats rapidly decreases the abundance of renal PEPCK mRNA by 50–72%. This reduction takes place in normal euglycemic, in insulin-induced hypoglycemic, and in streptozotocin-induced hyperglycemic diabetic animals. The effect of glucose is not seen in the presence of metabolic acidosis, whether induced by NH4Cl or by prolonged fasting. Therefore, it appears that oral glucose loading is a physiological suppressor of renal PEPCK message abundance, although not in acidosis.

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