Introduction/Objective. The aim of this study is to examine the association
of E-cadherin expression and high proliferation index (proIDX) with clinical
and pathological indicators of colorectal cancer progression. Methods. The
biopsy of 72 patients, obtained by resection of colorectal cancer, was
routinely processed at the Institute of Pathology of the Clinical Centre of
Montenegro, embedded in paraffin and archived. Based on the archived
pathohistological reports, two study groups were formed: the first group (n
= 72) consisted of operative biopsies of colorectal cancer, and the control
group (n = 72) consisted of biopsies of adjacent non-tumor tissue. Routine
hematoxylin-eosin and immunohistochemical ABC method with anti-Ki67 and
anti-E-cadherin antibodies was applied on. After quantification of the
results for statistical tests, the software package SPSS for Windows (19.0)
was used. Results. In colorectal carcinoma, we observed a significant
association of proIDX with pT stage, lymph and blood vessel invasion,
perineural invasion, lymph node metastases and distant metastases, and
Astler-Coller stage tumor disease. We also observed that the absence of
E-cadherin was significantly associated with pT stage, lymph and blood
vessel invasion, perineural invasion with lymph node metastases, distant
metastases, with C2 and D Astler-Coller tumor stage. E-cadherin expression
is associated with proIDX with a significantly high, negative correlation
coefficient. Conclusion. Our results indicate that it is possible to
differentiate patients into groups with a higher or lower risk of developing
metastatic disease, based on the expression of Ki67 and E-cadherin.
Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma