Clinical and histomorphometric evaluation of extraction sockets treated with an autologous bone marrow graft

2010 ◽  
Vol 21 (5) ◽  
pp. 535-542 ◽  
Author(s):  
André Antonio Pelegrine ◽  
Carlos Eduardo Sorgi da Costa ◽  
Maria Elvira Pizzigatti Correa ◽  
José Francisco Comenalli Marques
Blood ◽  
1987 ◽  
Vol 70 (1) ◽  
pp. 271-275
Author(s):  
SD Rowley ◽  
M Zuehlsdorf ◽  
HG Braine ◽  
OM Colvin ◽  
J Davis ◽  
...  

Autologous bone marrow transplants (BMTs) can repopulate the hematologic system of patients treated with marrow-ablative chemotherapy and/or radiotherapy. However, treatment of the bone marrow graft to eliminate residual tumor cells prior to reinfusion can delay the return of peripheral blood elements, presumably from damage to or loss of hematopoietic stem cells responsible for hematologic recovery. To develop a model predictive of hematologic recovery, we studied the progenitor cell contents of 4-hydroperoxycyclophosphamide (100 micrograms/mL)-purged bone marrow grafts of 40 consecutive patients undergoing autologous BMT at this center. Granulocyte-macrophage colonies (CFU-GM) were grown from all grafts after treatment with this chemotherapeutic agent, but erythroid (BFU-E) and mixed (CFU-GEMM) colonies were grown from only 44% and 33% of the grafts respectively. The recovery of CFU-GM after purging ranged from 0.07% to 23%. The logarithm of CFU-GM content of the treated grafts was linearly correlated with the time to recovery of peripheral blood leukocytes (r = -0.80), neutrophils (r = -0.79), reticulocytes (r = -0.60), and platelets (r = -0.66). The CFU-GM content of purged autologous bone marrow grafts may reflect the hematopoietic stem cell content of the grafts and thus predict the rate of hematologic recovery in patients undergoing autologous BMT.


1979 ◽  
Vol 43 (4) ◽  
pp. 681-682 ◽  
Author(s):  
P. Herve ◽  
E. Tamayo ◽  
R. Lenys ◽  
A. Peters ◽  
A. Rozenbaum ◽  
...  

2009 ◽  
Vol 19 (4-5) ◽  
pp. 277-281
Author(s):  
Laurent Galois ◽  
Danièle Bensoussan ◽  
Jérôme Diligent ◽  
Astrid Pinzano ◽  
Cristel Henrionnet ◽  
...  

Blood ◽  
1987 ◽  
Vol 70 (1) ◽  
pp. 271-275 ◽  
Author(s):  
SD Rowley ◽  
M Zuehlsdorf ◽  
HG Braine ◽  
OM Colvin ◽  
J Davis ◽  
...  

Abstract Autologous bone marrow transplants (BMTs) can repopulate the hematologic system of patients treated with marrow-ablative chemotherapy and/or radiotherapy. However, treatment of the bone marrow graft to eliminate residual tumor cells prior to reinfusion can delay the return of peripheral blood elements, presumably from damage to or loss of hematopoietic stem cells responsible for hematologic recovery. To develop a model predictive of hematologic recovery, we studied the progenitor cell contents of 4-hydroperoxycyclophosphamide (100 micrograms/mL)-purged bone marrow grafts of 40 consecutive patients undergoing autologous BMT at this center. Granulocyte-macrophage colonies (CFU-GM) were grown from all grafts after treatment with this chemotherapeutic agent, but erythroid (BFU-E) and mixed (CFU-GEMM) colonies were grown from only 44% and 33% of the grafts respectively. The recovery of CFU-GM after purging ranged from 0.07% to 23%. The logarithm of CFU-GM content of the treated grafts was linearly correlated with the time to recovery of peripheral blood leukocytes (r = -0.80), neutrophils (r = -0.79), reticulocytes (r = -0.60), and platelets (r = -0.66). The CFU-GM content of purged autologous bone marrow grafts may reflect the hematopoietic stem cell content of the grafts and thus predict the rate of hematologic recovery in patients undergoing autologous BMT.


Blood ◽  
1963 ◽  
Vol 21 (5) ◽  
pp. 620-625
Author(s):  
E. MAGLIULO ◽  
B. G. CROUCH ◽  
M. J. DE VRIES

Abstract 1. The average values and the range of drumstick counts in the neutrophil granulocytes in males and females of a normal group of rhesus monkeys were estimated. 2. No important individual differences in counting were found between two groups of workers. 3. Irradiation and treatment with autologous bone marrow does not influence the drumstick appendage frequency. 4. The drumstick counts are an important indication of the take of a bone marrow graft when female donors and male hosts are used.


2007 ◽  
Vol 361-363 ◽  
pp. 1245-1248 ◽  
Author(s):  
Franck Jegoux ◽  
Eric Aguado ◽  
Ronan Cognet ◽  
Oliver Malard ◽  
Françoise Moreau ◽  
...  

The aim of this study was to study bone marrow quality from various location and species for reconstruction of segmental critical size defect in irradiated weigh bearing bone. Sample of bone marrow aspirates from rabbits and Beagle dog were analyzed. Rabbits were implanted with a composite associating resorbable collagen membrane plus micro macroporous biphasic calcium phosphate (MBCP®) and autologous bone marrow (BM) injected after irradiation. Bone marrow samples were found to be significantly less rich in tibia than in humerus and ilium in Dog and less rich in Dog than in Rabbit (p<0,05). Successful osseous colonization bridging of the defect were obtain at 16 weeks in all animals. Identical repartition of bone ingrowth and residual ceramic at the different levels of the implant suggest an osteoinduction role of the bone marrow graft in the center of the defect. This model succeeded in reconstruct a large segmental defect in weight bearing and irradiated bone in rabbit.


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