Recurrent herpes labialis in US children and youth

Introduction: Given the indefinite effect of antinucleoside drugs on the improvement of Recurrent Herpes Labialis, plant medicines such as Melissa officinalis have been proposed as a treatment of choice for these lesions. Clinical studies have reported different and conflicting results for the effect of Melissa on herpes. Hence, using a systematic approach, this study aimed to evaluate the clinical studies on the effect of Melissa on recurrent herpes labialis compared to acyclovir or placebo. Description: The English and Persian controlled clinical trials on the effect of Melissa on recurrent herpes labialis compared to acyclovir or placebo were investigated. Persian databases, including SID, Civilica, Medical Library, and Iranian Medical Sciences Theses and English databases content ProQuest, PubMed Google Scholar, were searched from 1990 to 2018 using a pre-designed strategy. Quality assessment of studies performed using the CONSORT-2010 checklist. The exclusion criteria of this study resemble details of both Persian and English searches/ articles, and eliminating one of them, invitro studies, and studies lacking an acceptable score by the CONSORT checklist. Out of 955 reviewed and evaluated articles from the 2010 consort checklist, 3 articles scored above 7.2 Articles were in English and 1 Article was in Persian. The search results were evaluated by the quality assessment of the recruited studies’ results. Compared to acyclovir and placebo, Melissa was more effective in reducing the lesion pain and size but had no significant effect on decreasing inflammation and erythema. The administration of the drugs did not provide any side effects. Conclusion: Melissa was more effective than Acyclovir and placebo in reducing the lesion pain and size but did not significantly decrease inflammation and erythema.

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Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

10.21203/rs.3.rs-15508/v1 ◽

2020 ◽

Author(s):

Zahra Ranjbar ◽

Maryam Zahed ◽

Mohammad Ali Ranjbar ◽

Zahra Shirmardan

Keyword(s):

Healthy Subjects ◽

Serum Zinc ◽

Zinc Level ◽

Therapeutic Effects ◽

Herpes Labialis ◽

Healthy Individuals ◽

Serum Zinc Level ◽

Significant Difference ◽

Recurrent Herpes ◽

History Of

Abstract Background: Recurrent herpes labialis (RHL) is one of the most common recurrent infective vesiculoulcerative lesions. Topical and systemic administration of Zinc compounds has been found to have preventive and therapeutic effects. The purpose of this article is to evaluate the serum level of zinc in patients with RHL and healthy individuals. Methods: This cross-sectional study was performed on 43 patients with the history of recurrent herpers labialis and 42 healthy subjects with no history of the lesion. Blood samples were taken and serum zinc level was measured. Chi-Square test was used to compare the qualitative relationships and to compare the quantitative relationships independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses and recovery rates correlation test was taken. Results: The results show that serum zinc level has no significant difference in healthy subjects and patients (p> 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (P> 0.05). But surprisingly in the patients group, there was a significant relationship between zinc level and recovery period. As the serum zinc level was lower, the duration of recovery was significantly higher (p =0.009). Conclusion: The results of this study indicate that zinc deficiency is a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in subjects with recurrent herpes labialis and subsequent administration of zinc is recommended in such patients.

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