scholarly journals Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

2020 ◽  
Author(s):  
Zahra Ranjbar ◽  
Maryam Zahed ◽  
Mohammad Ali Ranjbar ◽  
Zahra Shirmardan
Keyword(s):  
Healthy Subjects ◽  
Serum Zinc ◽  
Zinc Level ◽  
Therapeutic Effects ◽  
Herpes Labialis ◽  
Healthy Individuals ◽  
Serum Zinc Level ◽  
Significant Difference ◽  
Recurrent Herpes ◽  
History Of

Abstract Background: Recurrent herpes labialis (RHL) is one of the most common recurrent infective vesiculoulcerative lesions. Topical and systemic administration of Zinc compounds has been found to have preventive and therapeutic effects. The purpose of this article is to evaluate the serum level of zinc in patients with RHL and healthy individuals. Methods: This cross-sectional study was performed on 43 patients with the history of recurrent herpers labialis and 42 healthy subjects with no history of the lesion. Blood samples were taken and serum zinc level was measured. Chi-Square test was used to compare the qualitative relationships and to compare the quantitative relationships independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses and recovery rates correlation test was taken. Results: The results show that serum zinc level has no significant difference in healthy subjects and patients (p> 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (P> 0.05). But surprisingly in the patients group, there was a significant relationship between zinc level and recovery period. As the serum zinc level was lower, the duration of recovery was significantly higher (p =0.009). Conclusion: The results of this study indicate that zinc deficiency is a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in subjects with recurrent herpes labialis and subsequent administration of zinc is recommended in such patients.

scholarly journals Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Zahra Ranjbar ◽  
Maryam Zahed ◽  
Mohammad Ali Ranjbar ◽  
Zahra Shirmardan
Keyword(s):  
Recovery Period ◽  
Serum Zinc ◽  
Zinc Level ◽  
Therapeutic Effects ◽  
Herpes Labialis ◽  
Healthy Individuals ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Recurrent Herpes

Abstract Background Recurrent herpes labialis (RHL) is a common recurrent infective vesiculoulcerative disease. Topical and systemic administration of Zinc compounds has been indicated to have preventive and therapeutic effects. The purpose of this study was to evaluate the serum level of zinc in the patients with RHL and healthy individuals and also to investigate the correlation of this level with various parameters of the patient and disease course. Methods This cross-sectional study was performed on 43 patients with a history of recurrent herpers labialis and 42 subjects without any previous experience of the lesion. Blood samples were taken, and serum zinc level was measured using colorimetry (spectrophotometry) method. Chi-Square test was used to compare the qualitative relationships, and for comparing the quantitative relationships, independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses, and recovery rates, correlation test was taken. Results The results show that, serum zinc level has no significant difference between healthy subjects and the patients (p > 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (p > 0.05). However surprisingly, there was a significant relationship between zinc level and recovery period in the RHL patients. The lower the serum zinc level, the higher the duration of recovery (p = 0.009). Conclusion The results of this study indicate that, zinc deficiency can be considered as a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in the subjects with RHL and subsequent administration of zinc are recommended in these kind of patients.

scholarly journals A study of serum zinc levels in children with febrile convulsions in comparison with normal and febrile children

2020 ◽  
Vol 7 (3) ◽  
pp. 588
Author(s):  
Madhubalan T. ◽  
Chidambaranathan S. ◽  
Ramamoorthy R.
Keyword(s):  
Statistical Significance ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Normal Children ◽  
Febrile Convulsions ◽  
Significant Difference ◽  
Zinc Levels ◽  
The Brain ◽  
Serum Zinc Levels

Background: A seizure is a paroxysmal time-limited change in motor activity and or behavior that results from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain such as high fever, infection, syncope, head trauma, hypoxia, or toxins. To determine whether children with febrile convulsion have decreased serum zinc level when compared to normal children and children with fever without convulsions.Methods: The study included children admitted with bronchiolitis in between during the period of September 2018 to January 2019 at Department of Pediatrics, Raja Muthiah Medical College and Hospital. It is a case-control study. A sample size of 50 was selected for each group Totally 3 Groups, 1. Children with febrile convulsions,2. Children with fever without convulsions, 3. Normal Children.Results: The mean serum zinc level in children with febrile convulsions was 42.9 mcg/dl. The serum zinc level in children with fever and normal children was 70 mcg/dl and 71 mcg/dl respectively. On comparing the serum zinc level among the three groups statistical significance was obtained between children with febrile convulsions and the other two groups namely normal children and children with fever alone. Thus, decreased serum zinc level is a significant predisposing factor for febrile convulsions. By using Posthoc Multiple comparisons test we came to know that the Fever convulsion group is significantly different from fever and normal group. There is no significant difference between fever and normal group.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions, thus indicating that zinc deprivation plays a significant role in the pathogenesis of febrile convulsions.

scholarly journals Correlation between Serum Zinc Level and Erythrocyte Superoxide Dismutase (SOD) Activity in Non-frail and Frail Geriatric Patients

2017 ◽  
Vol 1 (1) ◽  
pp. 34
Author(s):  
Rosnah Pinontoan ◽  
Savitri Sayogo ◽  
Arya Govinda Roosheroe
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Venous Blood ◽  
Serum Zinc ◽  
Zinc Level ◽  
Zn Deficiency ◽  
Serum Zinc Level ◽  
Physical Measurements ◽  
Significant Difference ◽  
The Mean

Introduction: Frailty syndrome (FS), as a health problem in elderly, can interfere with the quality of life. Many factors play roles in its occurrence, one of which is oxidative stress. Superoxide dismutase (SOD), in which one of its components is zinc (Zn), is one of the endogenous antioxidants that plays a role in preventing oxidative stress. This study was aimed to know the correlation between serum zinc level (sZn) and erythrocyte SOD (eSOD) activity in non-frail and frail geriatric patients.Methods: This was cross-sectional study with consecutive sampling method conducted in the Geriatric Clinic Cipto Mangunkusumo hospital, from August through September 2014, on 60 patients (30 patients for each group of non-frail and frail). Data were collected from interviews, physical measurements, and venous blood sampling.Results: Among 90% of the subjects had low Zn intake, at the same time, the mean of sZn was 8.41 ± 1.36mol/l and 93.3% of the subjects had experienced Zn deficiency. The mean of eSOD activity was 1526 ± 508U/gHb, and there was no significant difference between the groups. There were no significant correlation between sZn and eSOD activity both in the overall subject (r = -0.04; p = 0.076), as well as the non-frail group (r = -0.099; p=0.604) and frail  group (r = 0.01; p = 0.957).Conclusion: Serum zinc level did not have any significant correlation with the eSOD activity, neither on overall or both non-frail and frail groups.

scholarly journals Correlation between serum zinc level and simple febrile seizure in children

2016 ◽  
Vol 50 (6) ◽  
pp. 326 ◽  
Author(s):  
Lusiana Margaretha ◽  
Nurhayati Masloman
Keyword(s):  
Central Nervous System ◽  
Acute Diarrhea ◽  
Febrile Seizure ◽  
Serum Zinc ◽  
Hemorrhagic Fever ◽  
Zinc Level ◽  
Acute Respiratory Tract Infection ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
History Of

Background Simple febrile seizure is the most common form of seizure which occurs during childhood period. Zinc, one of microelements in human body, has an important role in central nervous system formation.Objectives To find out serum zinc level in simple febrile seizure patients and the correlation between serum zinc level and simplefebrile seizure.Methods This cros-sectional study was conducted at R. D. Kandoll Hospital, Tingkat III Teling Hospital and Pancaran Kasih Hospital, Manado on April 5th - June 15th, 2009.Results Diagnosis for febrile v.ithout seizure patients were 12 with acute respiratory tract infection (ARl), 6 dengue hemorrhagic fever (DHF), 6 acute diarrhea v.ithout dehydration and 1 ARI with DHF, while simple febrile seizure were 19 ARI, five acute diarrhea v.ithout dehydration and one ARI v.ith DHF. There were no significant differences of age, gender and nutritional status in two groups. F amily history of febrile seizure, febrile period and body temperature in two groups were significantly different. Mean serum zinc level in simple febrile seizure and febrile v.ithout seizure were 8.83 μmol/L and 13.72 μmol/L, respectively. Mean serum zinc level in simple febrile seizure children with seizure period <5 minutes, 5-<10 minutes and 10-15 minutes were 10.27 (SD 0.25)  μmol/L, 9.02 (SD 0.81) ) μmol/L and 6.90 (SD) 0.98 μmol/L, respectively.Conclusions There is correlation between serum zinc level and simple febrile seizure. The lesser serum zinc level, the longer duration of seizure occurs in simple febrile seizure.

scholarly journals Estimation of serum zinc levels in children with febrile convulsions

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

scholarly journals Serum Zinc, Total & Free PSA, Free/Total PSA Ratio and Prostate Cancer Association: A Case Control Study

2013 ◽  
Vol 4 (1) ◽  
pp. 15-19
Author(s):  
Md Tahminur Rahman ◽  
Mahbuba Ashrafi Mumu ◽  
ATM Mowladad Choudhury ◽  
Rosy Sultana ◽  
Sonia Shirin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prostatic Cancer ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Free Psa ◽  
Significant Difference ◽  
Total Psa ◽  
Control Study

This case case control study was undertaken to see if there is any association of serum Zinc level with histologically diagnosed prostatic cancer patients. Also to re-establish the importance of estimation of serum Prostate specific antigen PSA, (Total, Free and ratio between free and total) in prostate cancer patients. It was evident from the present study that serum Zinc level has got statistically significant difference between control and prostate cancer patients (p<0.000),. Total PSA and ratio of free and total PSA was also significantly different between control and prostatic cancer patients (p<0.04 and 0.006 respectively). However no significant difference was observed in free PSA level between this two groups (p<0.282).It was concluded from the present study that serum Zinc level could be an adjuvant laboratory test in the diagnosis of prostate cancer and can be started as a routine test in case of suspected prostatic cancer. Also total PSA level and ratio of free and total PSA not free PSA should be done and correlated for diagnosis of prostate cancer. DOI: http://dx.doi.org/10.3329/akmmcj.v4i1.13679 AKMMC J 2013: 4(1): 15-19  

scholarly journals Growth Status and Serum Zinc Level in Patients with Haemoglobin –E-? Thalassemia

2012 ◽  
Vol 36 (2) ◽  
pp. 76-81
Author(s):  
AKM Amirul Morshed ◽  
Shahnoor Islam ◽  
Afiqul Islam
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Healthy Children ◽  
Serum Zinc Level ◽  
Blood Samples ◽  
Growth Status ◽  
Significant Difference ◽  
Hb E ◽  
And Control

Background: Hb- E - ? thalassemia is a major congenital hematological disease of Bangladesh. These patients have poor growth and delayed maturation mainly due to iron overload but zinc deficiency also has been suggested as a contributing factor. Objectives: To investigate and compare the serum zinc of Hb E ? thalassemia patients and normal children and to see the relationship between serum zinc and growth status. Methods: This cross sectional study on Hb –E ? thalassemia was under taken in the out patient department of Paediatric Haematology and Oncology department of Bangabandhu Sheikh Mujib Medical University from July 2009- May 2010. Total 31 children with Hb- E- ? thalassemia were enrolled for this study and matched 30 healthy children were taken as control. History of the cases were taken thoroughly and examination were done by the investigator himself. Anthropometry were measured properly and plotted in Centre for Disease Control (CDC) chart. Three ml (3 ml) of venous blood samples were drawn from both patient and control. Later on the blood samples were centrifuged and serum was stored at – 20c till analysis for serum sinc level. Serum level of zinc was measured by using Flame Atomic Absorption Spectrophotometry following standard proceduve. Results: Mean serum zinc level in thalassemic group and control group were 97.4?g/dl (SD-18.4) and 99.6?g/dl (SD-18.7) respectively. There was no significant difference between two groups (p=.47). Mean percent of 50th centile of weight achieved was 75.9% in cases and 81% in control. Similarly mean percent of 50th centile of height achieved was 89% in cases and 93% in control. There was significant difference in height for age between both the groups (p=.05). Conclusion: Serum zinc level did not significantly changed in thalassemic group and control group children. But there were significant stunting in Hb –E ? thalassemia patients and no significant difference was found between these children in terms of weight for age. DOI: http://dx.doi.org/10.3329/bjch.v36i2.13083 Bangladesh J Child Health 2012; Vol 36 (2): 76-81

scholarly journals Zinc (?)-immune pediatric virucidal activities for 2019-nCoV prevention and therapeutic effects of COVID-19 bronchitis and pneumonia

2020 ◽  
Vol 1 (2) ◽  
pp. 01-06
Author(s):  
Sci. Tsuneo Ishida
Keyword(s):  
Zinc Supplementation ◽  
Respiratory Infections ◽  
Serum Zinc ◽  
Zinc Level ◽  
Lung Injury Score ◽  
Therapeutic Effects ◽  
Coordination Pattern ◽  
Serum Zinc Level ◽  
Zinc Gluconate ◽  
Acute Lower Respiratory Infections

Zinc (Ⅱ)-immune pediatric virucidal activities for children with 2019-nCoV prevention and COVID-19 bronchitis and pneumonia are discussed, and these Zn2+-immune pediatric virucidal effects result in the following. Zinc intakes by zinc induced immunity are required 3 mg/day for 7 month to 3 years, 5 mg/day for 4～ 8 years, and 8 mg/day for 9 ～13 years in children. Zinc supplementation have been assessed, from 15 mg to 140 mg/week, with the upper range exceeding the recommended daily infection (RDI) for children of 2 mg/day for children less than one year of age and up to 7 mg/day for children between 1 to 3 years. Zinc induced pediatric preventing respiratory 2019-nCoV is required that supplementation with zinc gluconate 20 mg in Zn deficient children resulted in a nearly twofold reduction of acute lower respiratory infections as well as the time to recovery. Zinc supplementation in children is associated with a reduction in the incidence and prevalence of pneumonia. Preventing 2019-nCoV pneumonia is required that zinc supplementation alone (10 to 20 mg) for more than 3 months significantly reduces in the rate of pneumonia. Prophylactic zinc supplementation for two weeks may reduce the morbidity due to acute lower respiratory infections. Zinc gluconate supplement may result in significant reduction in respiratory morbidity among children with acute lower respiratory infections. In addition. as serum zinc level of Acute Respiratory Infection (ARI)-children was very low, higher zinc concentration treatments as low sociodemographic factors, poor nutritional status and male children were prevalently associated with higher incidence of acute respiratory infections. Adjuvant treatment with 20 mg zinc/day accelerates recovery from severe pneumonia in children. Primary outcome was recovery from pneumonia and 30 mg/day of zinc supplementation reduces pneumonia in children with chronic kidney disease (CKD). Zinc supplementation + Chloroquine (CQ)/hydroxychloroquine (HCQ) may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. The serum zinc level returned to a normal level (median, 53.20 μmol/L) on day 12±2 in the treatment. There was no statistical difference in the pediatric critic illness score, lung injury score, length of hospital stay, and duration of mechanical ventilation between the zinc treatments. The oxidative stress in pediatric diseases causes an oxidative burst that results in a respiratory burst and rapid ROS production. Thus, zinc pediatric intake may be required to be effective range 10～20 mg/d for 2019-CoV prevention, 10～30 mg/d for reduction of COVID-19 bronchitis, and 20～30 mg/d for recovery from COVID-19 pneumonia, in which Zn2+ could bind with viral surface proteins by Zn2+ions-centered tetrahedrally coordination pattern.

scholarly journals Serum Zinc status in patients with haemoglobin-E ? thalassemia

2015 ◽  
Vol 22 (2) ◽  
pp. 115-119
Author(s):  
AKM Amirul Morshed ◽  
Shahnoor Islam ◽  
Tasrina Rabeya Chowdhury ◽  
Afiqul Islam ◽  
Ariful Islam ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Initial Assessment ◽  
Control Group ◽  
Healthy Children ◽  
Serum Zinc Level ◽  
Poor Growth ◽  
Flame Atomic Absorption ◽  
Significant Difference ◽  
Hb E

Background: Hb-E â thalassemia is a major congenital hematological disease of Bangladesh. The patients have poor growth and delayed maturation mainly due to iron overload but zinc deficiency also has been suggested as a contributing factor. The aim of this study was to investigate and compare the serum zinc of HbE-â thalassemia patients and normal children. Methods: This cross sectional study was done in the Department of Paediatric Haematology and Oncology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from July 2009 to May 2010. A total of 31children with Hb-E â thalassemia were enrolled for this study and besides, matched 30 healthy children were taken as control. After initial assessment the cases were thoroughly examined by the investigators and history of transfusion, transfusion interval were recorded. Venous blood samples (3mL) were drawn from patients and normal control children then centrifuged and stored at -20°C until analyzed. Serum level of zinc was measured by using Flame Atomic Absorption Spectrophotometry. Results: Mean serum zinc level in thalassemic group and control group were 97.4?g/dl (SD- 18.4) and 99.6?g/dl (SD-18.7) respectively. There is no significant difference between two groups (p=0.47). Conclusion: It may be concluded from this study that serum zinc level did not significantly change in children with Hb-E â thalassemia DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21518 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 115-119

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