ORIGINAL ARTICLE: Anti-Elastin Antibodies and Elastin Turnover in Normal Pregnancy and Recurrent Pregnancy Loss

The objective of the present study was to see the prevalence of anticardiolipin antibody (ACA) in Bangladeshi patients (35) with recurrent pregnancy loss. Thirty-seven women with normal pregnancy were included as control. Serum levels (mean ± SD) of ACA (u/mL) was significantly higher, whereas ANA (Ab-index) and anti-dsDNA (Ab-index) were similar in cases compared to controls (Cases vs Controls g ACA: 31.8 ± 24.3 vs 10.5 ± 3.4, p<0.001; ANA: 1.07 ± 0.34 vs 0.92 ± 0.15, p>0.5; A-dsDNA: 0.53 ± 0.16 vs 0.52 ± 0.18, p>0.5). The cases positive for ACA, ANA and anti-dsDNA were 37.1% (p<0.001), 20% (p>0.05) and 2.8% (p>0.1) respectively. Among the seropositive cases 4/35 (11.4%) and 4/13 (30.8%) were positive for both ACA and ANA. In controls only 2/37 (5.4%) and 2/37 (5.4%) were positive for ACA and ANA respectively and none were positive for both ACA and ANA together simultaneously. Significantly high proportion of cases had O positive blood group (23/35: 65.7%, 10/13: 76.9%) (p<0.01). The prevalence of ACA varies according to population being 37.1% (13/35) in our patients with recurrent pregnancy loss and 5.4% in controls.Online: 13 July 2010DOI: http://dx.doi.org/10.3329/bmrcb.v36i1.5446Bangladesh Med Res Counc Bull 2010; 36: 10-13

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Anti-fibrillin-1 autoantibodies in normal pregnancy and recurrent pregnancy loss

Autoimmunity Reviews ◽

10.1016/j.autrev.2010.09.003 ◽

2011 ◽

Vol 10 (3) ◽

pp. 131-136 ◽

Cited By ~ 1

Author(s):

Milena Atanasova Atanasova ◽

Emiliana Ilieva Konova ◽

Tania Ace Aleksovska ◽

Katia Nikolova Todorova ◽

Miglena Nikolaeva Georgieva ◽

...

Keyword(s):

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Normal Pregnancy ◽

Fibrillin 1

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Comparison of gene expression at the fetomaternal interface between normal and recurrent pregnancy loss patients

Reproduction Fertility and Development ◽

10.1071/rd02008 ◽

2002 ◽

Vol 14 (4) ◽

pp. 235 ◽

Cited By ~ 13

Author(s):

Kwang-Hyun Baek ◽

Bum Chae Choi ◽

Jin-Hie Lee ◽

Hee-Kyung Choi ◽

Sook-Hwan Lee ◽

...

Keyword(s):

Gene Expression ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Expression Patterns ◽

Subtractive Hybridization ◽

Normal Pregnancy ◽

Chorionic Villi ◽

Expression Of Genes ◽

Different Levels ◽

In Pregnancy

—Normal pregnancy requires a series of immunological, metabolic, vascular and endocrine regulating processes. However, the specific genes and proteins involved in these processes are not well defined. Aberration of these processes may lead to problems in pregnancy. One of these problems may be recurrent pregnancy loss (RPL). Little information is available on the level of expression of genes that may play a role in normal pregnancy. Therefore, this study determined whether different levels of gene expression at the feto-maternal interface could be associated with factors for RPL. The expression patterns of genes isolated from subtractive hybridization analysis performed with chorionic villi from normal and abnormal pregnancies were investigated. Eight genes classified into groups, including immunosuppression-related, embryo attachment-related and angiogenesis-related, were isolated.

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Angiogenesis and oxidative stress-related gene variants in recurrent pregnancy loss

Reproduction Fertility and Development ◽

10.1071/rd17117 ◽

2018 ◽

Vol 30 (3) ◽

pp. 498 ◽

Cited By ~ 4

Author(s):

Marcela Felix Fortis ◽

Lucas Rosa Fraga ◽

Juliano André Boquett ◽

Thayne Woycinck Kowalski ◽

Caroline Gross Dutra ◽

...

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Normal Pregnancy ◽

Susceptibility Factors ◽

Increased Risk ◽

Prostaglandin Endoperoxide Synthase ◽

Oxide Synthase ◽

Endothelial Growth Factor

Recurrent pregnancy loss (RPL) affects ~3–5% of couples attempting to conceive and in around 50% of cases the aetiology remains unknown. Adequate vascularisation and placental circulation are indispensable for the development of a normal pregnancy. Prostaglandin-endoperoxide synthase 2 (PTGS2), vascular endothelial growth factor (VEGF) and the nitric oxide (NO) systems play important roles in reproductive physiology, participating in several steps including implantation and apoptosis of trophoblast cells. In this study we evaluated genetic polymorphisms in the inducible nitric oxide synthase (NOS2), PTGS2 and VEGFA genes as susceptibility factors for RPL. A case-control study was conducted in 149 women having two or more miscarriages and 208 controls. Allele and genotype distributions of the polymorphisms studied in the two groups were not statistically different. However, the dominant model showed that the presence of variant T (TT/GT) of rs2779249 (−1290G > T) of NOS2 was significantly associated with RPL (OR = 1.58, CI 95% = 1.03–2.44; P = 0.037). The increased risk remained significant when adjusted for number of pregnancies, alcohol consumption and ethnicity (OR = 1.92, CI95% = 1.18–3.11; P = 0.008). These results suggest that the variant genotypes of the functional polymorphism rs2779249 in the NOS2 promoter are a potential risk for RPL, possibly due to oxidative stress mechanisms.

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