scholarly journals T cells in normal pregnancy and recurrent pregnancy loss

2006 ◽  
Vol 13 (6) ◽  
pp. 840-844 ◽  
Author(s):  
Marie-Pierre Piccinni
Keyword(s):  
T Cells ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Normal Pregnancy

Increased amount of regulatory T cells may be required in attaining an ongoing uncomplicated pregnancy after unexplained recurrent pregnancy loss.

Placenta ◽  
2021 ◽  
Vol 112 ◽  
pp. e22
Author(s):  
Juliette Krop ◽  
Marie-Louise van der Hoorn ◽  
Hanneke Kapsenberg ◽  
Carin van der Keur ◽  
Frits Koning ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Uncomplicated Pregnancy

scholarly journals Prevalence of anticardiolipin antibody in Bangladeshi patients with recurrent pregnancy loss

1970 ◽  
Vol 36 (1) ◽  
pp. 10-13 ◽  
Author(s):  
A.S.M. Giasuddin ◽  
Ishrat Mazhar ◽  
A.M. Mujibul Haq
Keyword(s):  
Blood Group ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Anticardiolipin Antibody ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Control Serum

The objective of the present study was to see the prevalence of anticardiolipin antibody (ACA) in Bangladeshi patients (35) with recurrent pregnancy loss. Thirty-seven women with normal pregnancy were included as control. Serum levels (mean ± SD) of ACA (u/mL) was significantly higher, whereas ANA (Ab-index) and anti-dsDNA (Ab-index) were similar in cases compared to controls (Cases vs Controls g ACA: 31.8 ± 24.3 vs 10.5 ± 3.4, p<0.001; ANA: 1.07 ± 0.34 vs 0.92 ± 0.15, p>0.5; A-dsDNA: 0.53 ± 0.16 vs 0.52 ± 0.18, p>0.5). The cases positive for ACA, ANA and anti-dsDNA were 37.1% (p<0.001), 20% (p>0.05) and 2.8% (p>0.1) respectively. Among the seropositive cases 4/35 (11.4%) and 4/13 (30.8%) were positive for both ACA and ANA. In controls only 2/37 (5.4%) and 2/37 (5.4%) were positive for ACA and ANA respectively and none were positive for both ACA and ANA together simultaneously. Significantly high proportion of cases had O positive blood group (23/35: 65.7%, 10/13: 76.9%) (p<0.01). The prevalence of ACA varies according to population being 37.1% (13/35) in our patients with recurrent pregnancy loss and 5.4% in controls.Online: 13 July 2010DOI: http://dx.doi.org/10.3329/bmrcb.v36i1.5446Bangladesh Med Res Counc Bull 2010; 36: 10-13 

Peripheral Gamma Delta T cells secrete inflammatory cytokines in women with idiopathic recurrent pregnancy loss

Cytokine ◽  
2018 ◽  
Vol 102 ◽  
pp. 117-122 ◽  
Author(s):  
Ayantika Talukdar ◽  
Reeta Rai ◽  
K. Aparna Sharma ◽  
D.N. Rao ◽  
Alpana Sharma
Keyword(s):  
T Cells ◽  
Inflammatory Cytokines ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Gamma Delta T Cells ◽  
Gamma Delta

scholarly journals An imbalance in interleukin-17-producing T and Foxp3+ regulatory T cells in women with idiopathic recurrent pregnancy loss

2011 ◽  
Vol 26 (11) ◽  
pp. 2964-2971 ◽  
Author(s):  
S. K. Lee ◽  
J. Y. Kim ◽  
S. E. Hur ◽  
C. J. Kim ◽  
B. J. Na ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Interleukin 17

Anti-fibrillin-1 autoantibodies in normal pregnancy and recurrent pregnancy loss

2011 ◽  
Vol 10 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Milena Atanasova Atanasova ◽  
Emiliana Ilieva Konova ◽  
Tania Ace Aleksovska ◽  
Katia Nikolova Todorova ◽  
Miglena Nikolaeva Georgieva ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Normal Pregnancy ◽  
Fibrillin 1

Th17 and Regulatory T cells in Women with Recurrent Pregnancy Loss

2012 ◽  
Vol 67 (4) ◽  
pp. 311-318 ◽  
Author(s):  
Sung Ki Lee ◽  
Jee Yun Kim ◽  
Millina Lee ◽  
Alice Gilman-Sachs ◽  
Joanne Kwak-Kim
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss

ORIGINAL ARTICLE: Anti-Elastin Antibodies and Elastin Turnover in Normal Pregnancy and Recurrent Pregnancy Loss

2009 ◽  
Vol 61 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Emiliana Konova ◽  
Tania Aleksovska ◽  
Milena Atanasova ◽  
Miglena Georgieva ◽  
Katia Todorova ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Normal Pregnancy

Comparison of gene expression at the feto–maternal interface between normal and recurrent pregnancy loss patients

2002 ◽  
Vol 14 (4) ◽  
pp. 235 ◽  
Author(s):  
Kwang-Hyun Baek ◽  
Bum Chae Choi ◽  
Jin-Hie Lee ◽  
Hee-Kyung Choi ◽  
Sook-Hwan Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Expression Patterns ◽  
Subtractive Hybridization ◽  
Normal Pregnancy ◽  
Chorionic Villi ◽  
Expression Of Genes ◽  
Different Levels ◽  
In Pregnancy

—Normal pregnancy requires a series of immunological, metabolic, vascular and endocrine regulating processes. However, the specific genes and proteins involved in these processes are not well defined. Aberration of these processes may lead to problems in pregnancy. One of these problems may be recurrent pregnancy loss (RPL). Little information is available on the level of expression of genes that may play a role in normal pregnancy. Therefore, this study determined whether different levels of gene expression at the feto-maternal interface could be associated with factors for RPL. The expression patterns of genes isolated from subtractive hybridization analysis performed with chorionic villi from normal and abnormal pregnancies were investigated. Eight genes classified into groups, including immunosuppression-related, embryo attachment-related and angiogenesis-related, were isolated.

Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss

2020 ◽  
Vol 13 (4) ◽  
pp. 306-317
Author(s):  
Elham Abdollahi ◽  
Seyed Abdolrahim Rezaee ◽  
Nafiseh Saghafi ◽  
Maryam Rastin ◽  
Vicki Clifton ◽  
...  
Keyword(s):  
Vitamin D ◽  
T Cells ◽  
Regulatory T Cells ◽  
Pregnant Women ◽  
Th17 Cells ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Mononuclear Cells ◽  
Control Group ◽  
Peripheral Blood Mononuclear

Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on pregnancy outcomes, which may include recurrent pregnancy loss through the mechanisms that are yet unknown. The aim of this study was to evaluate the effect of 1,25VitD3 on regulatory T cells (Tregs) and T helper17 (Th17) cell populations In vitro in unexplained recurrent pregnancy loss (URPL) patients and healthy women. Methods: Samples from 20 non-pregnant women with a history of URPL were compared to 20 normal non-pregnant women. Peripheral blood mononuclear cells (PBMC) were divided into 3 wells for each subject: in the presence of 1, 25 VitD3 (50 nM, for 16 hours), PHA (positive control) (10μM), and without any treatment (as a baseline or negative control). The percentage of regulatory T cells and Th17 cells was measured by flow cytometry at baseline and then after cell culture experiments. Results: Our study indicated that the percentage of Tregs in patients with URPL was significantly lower than the control group (2.42 ± 0.27 vs. 3.41 ± 0.29, P= 0.01). The percentage of Th17 cells was significantly greater in URPL patients compared to the control group (2.91 ± 0.33 vs. 1.18± 0.15, P=0.001). 1, 25VitD3 treatment significantly increased the percentage of Tregs from the baseline in the URPL group compared to that in the control group (1.23 ± 0.03 vs. 1.00 ± 0.03, P= 0.01). Conclusion: Vitamin D deficiency may be a contributor to recurrent pregnancy loss and suggests supplementation of women with Vit D pre-pregnancy may be protective against URPL.

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