MRI and ultrasound for hepatic fat quantification:relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease

2007 ◽  
Vol 96 (4) ◽  
pp. 542-547 ◽  
Author(s):  
Lucia Pacifico ◽  
Michela Celestre ◽  
Caterina Anania ◽  
Pasquale Paolantonio ◽  
Claudio Chiesa ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Metabolic Characteristics ◽  
Hepatic Fat

An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase

2020 ◽  
Vol 319 (4) ◽  
pp. G469-G480
Author(s):  
Simone Carotti ◽  
Katia Aquilano ◽  
Francesco Valentini ◽  
Sergio Ruggiero ◽  
Francesca Alletto ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fat Metabolism ◽  
Special Focus ◽  
Acid Lipase ◽  
Nonalcoholic Fatty Liver ◽  
Lysosomal Acid ◽  
Hepatic Fat

Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver steatosis develops as a result of the deregulation of pathways controlling de novo lipogenesis and fat catabolism. Recent evidences suggest the clinical relevance of a reduction in the activity of lysosomal acid lipase (LAL), which is a key enzyme for intracellular fat disposal, in patients with NAFLD. In this review, we provided a comprehensive overview of the critical steps in hepatic fat metabolism and alterations in these pathways in NAFLD, with a special focus on lipophagy and LAL activity. During NAFLD, hepatic fat metabolism is impaired at several levels, which is significantly contributed to by impaired lipophagy, in which reduced LAL activity may play an important role. For further research and intervention in NAFLD, targeting LAL activity may provide interesting perspectives.

scholarly journals Quantification of Hepatic Fat Fraction in Patients With Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Qinhe Zhang ◽  
Ying Zhao ◽  
Jingjun Wu ◽  
Luhan Xie ◽  
Anliang Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat ◽  
Fat Fraction

scholarly journals Imaging techniques for assessing hepatic fat content in nonalcoholic fatty liver disease

2008 ◽  
Vol 7 (3) ◽  
pp. 212-220 ◽  
Author(s):  
Ernesto Roldan-Valadez ◽  
Rafael Favila ◽  
Manuel Martínez-López ◽  
Misael Uribe ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Imaging Techniques ◽  
Fat Content ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat
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