Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise

SummaryPraeperitoneal administration of colloidal 198Au complicating the treatment of anascitic ovarian cancer is reported. Typical scintiscans and various clinical findings of muscle necrosis and radiation myositis are described. Administration of larger amount of saline solution preceding the radiogold instillation controlled by simultaneous scintiscanning are suggested as safety measures in patients when no ascitic fluid is present.

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Platelet Adhesion in Polytetrafluoroethylene (PTFE) Vascular Grafts In Vivo and the Influence of Increased Intramuscular Pressure-An Experimental Model

Thrombosis and Haemostasis ◽

10.1055/s-0038-1665334 ◽

1983 ◽

Vol 50 (04) ◽

pp. 881-884 ◽

Cited By ~ 3

Author(s):

J T Christenson ◽

P Qvarfordt ◽

S-E Strand ◽

D Arvidsson ◽

T Sjöberg ◽

...

Keyword(s):

Blood Flow ◽

Graft Failure ◽

Small Diameter ◽

Graft Material ◽

Intramuscular Pressure ◽

Initial Flow ◽

Early Graft ◽

Wick Technique ◽

Early Graft Failure

SummaryThrombogenicity of graft material is involved in early graft failure in small diameter grafts. The frequently seen postoperative swelling of the leg after distal revascularization may cause an increased intramuscular pressure and early graft failure.Pairs of 4 mm polytetrafluoroethylene (PTFE) grafts were implanted. Autologous platelets were labeled with mIn-oxine. Platelet adhesiveness onto the grafts were analyzed from gamma camera images. Intramuscular pressures were measured with wick technique. Blood flow was measured. One graft served as control the other as test graft. Ninety minutes after declamping the i. m. pressure was increased in the test-leg to 30 mmHg, and later to 60 mmHg.In the control-graft platelet uptake increased to a maximum 60 min after declamping. Blood flow and i.m. pressure remained uneffected. The test-grafts were initially similar but when i.m. pressure was increased to 30 mmHg activity in the grafts increased significantly. Blood flow decreased with 12% of initial flow. When i. m. pressure was raised to 60 mmHg platelet uptake continued to increase.An increased intramuscular pressure of 30 mmHg or more significantly increase the amount of platelets adhering onto PTFE grafts, emphasizing the need for measuring intramuscular pressures after lower limb vascular revascularizations.

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PATHOGENESIS OF COXSACKIE VIRUS INFECTION

Journal of Experimental Medicine ◽

10.1084/jem.93.3.247 ◽

1951 ◽

Vol 93 (3) ◽

pp. 247-266 ◽

Cited By ~ 31

Author(s):

Joseph L. Melnick ◽

Gabriel C. Godman

Keyword(s):

Virus Infection ◽

Striated Muscle ◽

Virus Titer ◽

Coxsackie Virus ◽

Quantitative Distribution ◽

Virus Level ◽

Coxsackie Virus Infection ◽

Muscle Necrosis ◽

Old Mice ◽

Different Tissues

The quantitative distribution of the Conn.-5 strain of Coxsackie virus in different tissues was determined by serial titration at intervals after inoculation of 4 to 5 day old mice. High titers were reached by the 2nd day in blood, heart, liver, muscle, intestine, and its contents, and these were maintained through the 8th day, except for the blood, in which the virus level fell earlier. In paralyzed mice, muscle and brain attained the highest titers and it was in these tissues alone that virus persisted through the 9th day of illness. The pathology of the infection has been briefly described. In particular, the evolution of morbid changes in striated muscle was correlated with the concentrations of virus in muscle. Acute muscle necrosis first occurred when there was a peak viral concentration (4th day), and reached maximal intensity on the 8th day. Scattered acute lesions continued to appear while the virus titer remained above 10–4, from the 9th to 12th day. With the decrease in the myositis, there was a concomitant decrease in the incidence of perceptible disease. Inflammation was found to follow upon the development of necrosis, and subsided slowly. Regeneration began very early, became exuberant, and led finally to restitution of the muscle.

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Effect of the pneumatic antishock garment on intramuscular pressure

Annals of Emergency Medicine ◽

10.1016/s0196-0644(84)80277-2 ◽

1984 ◽

Vol 13 (8) ◽

pp. 581-583 ◽

Cited By ~ 12

Author(s):

Carey D Chisholm ◽

David E Clark

Keyword(s):

Intramuscular Pressure

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The Changes in Intramuscular Pressure and Femoral Vein Flow With Continuous Passive Motion, Pneumatic Compressive Stockings, and Leg Manipulations

Clinical Orthopaedics and Related Research ◽

10.1097/00003086-199105000-00034 ◽

1991 ◽

Vol &NA; (266) ◽

pp. 218???225 ◽

Cited By ~ 1

Author(s):

HERBERT P. VON SCHROEDER ◽

RICHARD D. COUTTS ◽

EDMUND BILLINGS ◽

MICHAEL T. MAI ◽

MICHAEL ARATOW

Keyword(s):

Femoral Vein ◽

Continuous Passive Motion ◽

Intramuscular Pressure ◽

Passive Motion

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Muscle genome-wide expression profiling during disease evolution in mdx mice

Physiological Genomics ◽

10.1152/physiolgenomics.90370.2008 ◽

2009 ◽

Vol 37 (2) ◽

pp. 119-132 ◽

Cited By ~ 36

Author(s):

Mario Marotta ◽

Claudia Ruiz-Roig ◽

Yaris Sarria ◽

Jose Luis Peiro ◽

Fatima Nuñez ◽

...

Keyword(s):

Candidate Genes ◽

Genetic Defect ◽

Strong Relationship ◽

Pcr Analysis ◽

Mdx Mouse ◽

Mdx Mice ◽

Matrix Remodeling ◽

Disease Evolution ◽

Genome Wide ◽

Muscle Necrosis

Mdx mice show a milder phenotype than Duchenne patients despite bearing an analogous genetic defect. Our aim was to sort out genes, differentially expressed during the evolution of skeletal muscle mdx mouse disease, to elucidate the mechanisms by which these animals overcome the lack of dystrophin. Genome-wide microarray-based gene expression analysis was carried out at 3 wk and 1.5 and 3 mo of life. Candidate genes were selected by comparing: 1) mdx vs. controls at each point in time, and 2) mdx mice and 3) control mice among the three points in time. The first analysis showed a strong upregulation (96%) of inflammation-related genes and in >75% of genes related to cell adhesion, muscle structure/regeneration, and extracellular matrix remodeling during mdx disease evolution. Lgals3, Postn, Ctss, and Sln genes showed the strongest variations. The analysis performed among points in time demonstrated significant changes in Ecm1, Spon1, Thbs1, Csrp3, Myo10, Pde4b, and Adamts-5 exclusively during mdx mice lifespan. RT-PCR analysis of Postn, Sln, Ctss, Thbs1, Ecm1, and Adamts-5 expression from 3 wk to 9 mo, confirmed microarray data and demonstrated variations beyond 3 mo of age. A high-confidence functional network analysis demonstrated a strong relationship between them and showed two main subnetworks, having Dmd- Utrn- Myo10 and Adamts5- Thbs1- Spon1-Postn as principal nodes, which are functionally linked to Abca1, Actn4, Crebbp, Csrp3, Lama1, Lama3, Mical2, Mical3, Myf6, Pxn, and Sparc genes. Candidate genes may participate in the decline of muscle necrosis in mdx mice and could be considered potential therapeutic targets for Duchenne patients.

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Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise

Journal of Applied Physiology ◽

10.1152/jappl.2001.91.5.2351 ◽

2001 ◽

Vol 91 (5) ◽

pp. 2351-2358 ◽

Cited By ~ 33

Author(s):

K. M. Gallagher ◽

P. J. Fadel ◽

S. A. Smith ◽

K. H. Norton ◽

R. G. Querry ◽

...

Keyword(s):

Blood Pressure ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Arterial Blood Pressure ◽

Dynamic Exercise ◽

Positive Pressure ◽

Intramuscular Pressure ◽

Arterial Blood ◽

Exercise In Humans ◽

Cuff Occlusion

This investigation was designed to determine the role of intramuscular pressure-sensitive mechanoreceptors and chemically sensitive metaboreceptors in affecting the blood pressure response to dynamic exercise in humans. Sixteen subjects performed incremental (20 W/min) cycle exercise to fatigue under four conditions: control, exercise with thigh cuff occlusion of 90 Torr (Cuff occlusion), exercise with lower body positive pressure (LBPP) of 45 Torr, and a combination of thigh cuff occlusion and LBPP (combination). Indexes of central command (heart rate, oxygen uptake, ratings of perceived exertion, and electromyographic activity), cardiac output, stroke volume, and total peripheral resistance were not significantly different between the four conditions. Mechanical stimulation during LBPP and combination conditions resulted in significant elevations in intramuscular pressure and mean arterial pressure from control at rest and throughout the incremental exercise protocol ( P < 0.05). Conversely, there existed no significant changes in mean arterial pressure when the metaboreflex was stimulated by cuff occlusion. These findings suggest that under normal conditions the mechanoreflex is tonically active and is the primary mediator of exercise pressor reflex-induced alterations in arterial blood pressure during submaximal dynamic exercise in humans.

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THU0526 Acute paraspinal muscle necrosis with crack cocaine and heroin; a case report

10.1136/annrheumdis-2018-eular.2294 ◽

2018 ◽

Author(s):

A. Masood ◽

L. Attipoe ◽

D. D’Cruz ◽

S. Al-Saraj ◽

S. Williams ◽

...

Keyword(s):

Case Report ◽

Crack Cocaine ◽

Paraspinal Muscle ◽

Muscle Necrosis

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POST-CORONAVIRUS DISEASE 2019 DE QUERVAIN’S THYROIDITIS – A CASE REPORT AND LITERATURE REVIEW

Innovare Journal of Medical Sciences ◽

10.22159/ijms.2021.v9i2.40956 ◽

2021 ◽

pp. 4-6

Author(s):

MOHAMAD SAFWAN ◽

VIJAYAN KN ◽

NAJEEB ◽

JITHU TG

Keyword(s):

Neck Pain ◽

Beta Blockers ◽

Thyroid Stimulating Hormone ◽

Thyroid Function Tests ◽

C Reactive Protein ◽

Free T4 ◽

Persistent Fever ◽

Reactive Protein ◽

Technetium Uptake

De Quervain’s thyroiditis, also known as subacute thyroiditis (SAT), is a self-limiting inflammatory thyroid disease typically occurring a few weeks after a respiratory viral infection. A 29-year-old female with no comorbidities presented with persistent fever, neck pain, and swelling of 10 days duration. She also had tremors, fatigue, and palpitation. A careful enquiry revealed that she had been diagnosed with coronavirus disease 2019 (COVID-19) infection 6 weeks ago and had recovered uneventfully with conservative management. Her laboratories showed leukocytosis, elevated erythrocyte sedimentation rate, and C-reactive protein. Thyroid function tests (TFTs) yielded low thyroid-stimulating hormone, and high T3 and free T4. Ultrasonography neck was suggestive of thyroiditis. Thyroid scintigraphy demonstrated very low technetium uptake which confirmed SAT. Her symptoms ameliorated with nonsteroidal anti-inflammatory drug and beta-blockers and her TFTs improved during follow-up. We report this as emerging sequelae of COVID-19 infection. A persistent fever and neck pain following recent COVID-19 infection should alert clinician toward the possibility of de Quervain’s thyroiditis following severe acute respiratory syndrome coronavirus 2.

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