IMMUNOTHERAPY OF HUMAN MALIGNANT MELANOMA WITH IRRADIATED TUMOR CELLS, ORAL BACILLUS CALMETTE-GUÉRIN, AND LEVAMISOLE*

1976 ◽  
Vol 277 (1) ◽  
pp. 355-366 ◽  
Author(s):  
Henry R. Shibata ◽  
L. Martin Jerry ◽  
Martin G. Lewis ◽  
Peter W. A. Mansell ◽  
Alena Capek ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Tumor Cells ◽  
Bacillus Calmette Guerin ◽  
Human Malignant Melanoma

scholarly journals VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin

2019 ◽  
Author(s):  
Daniel Delgado-Bellido ◽  
Concepción Bueno-Galera ◽  
Angel Garcia-Diaz ◽  
F. Javier Oliver
Keyword(s):  
Endothelial Cells ◽  
Malignant Melanoma ◽  
Tumor Cells ◽  
Malignant Tumor ◽  
Vasculogenic Mimicry ◽  
P120 Catenin ◽  
Human Malignant Melanoma ◽  
Aberrant Phenotype ◽  
Autophagic Degradation ◽  
Vascular Expression

AbstractAberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone (VM+) tumor cells VE-cadherin is mainly in the form of pVE-cadherin in Y658 allowing an increased plasticity that potentiates VM development. As excessive VE-cadherin phosphorylation is regulated by the phosphatase VEPTP in endothelial cells in the current study we analysed its role in this aberrant phenotype in malignant tumor cells. We show that human malignant melanoma cells VM+, also express VE-PTP although at lower levels than endothelial cells. The complex VE-PTP/VE-Cadherin/p120-catenin act as a safeguard to prevent VE-cadherin degradation by autophagy. Indeed, silencing of VE-PTP results in complete degradation of VE-cadherin with the features of autophagy and increases the global p120 tyrosine phosphorylation status. In summary, we show that VE-PTP is involved in VM formation and disruption of VE-PTP/VE-Cadherin/p120 complex results in enhanced autophagy in aggressive VM+ cells.

The α subunit of S100 protein is present in tumor cells of human malignant melanoma, but not in schwannoma

1984 ◽  
Vol 294 (2) ◽  
pp. 381-384 ◽  
Author(s):  
Toshiaki Isobe ◽  
Kayoko Ichimori ◽  
Takashi Nakajima ◽  
Tsuneo Okuyama
Keyword(s):  
Malignant Melanoma ◽  
Tumor Cells ◽  
S100 Protein ◽  
Human Malignant Melanoma ◽  
Α Subunit

scholarly journals Toxicogenomics of A375 human malignant melanoma cells treated with arbutin

2006 ◽  
Vol 14 (1) ◽  
pp. 87-105 ◽  
Author(s):  
Sun-Long Cheng ◽  
Rosa Huang Liu ◽  
Jin-Nan Sheu ◽  
Shui-Tein Chen ◽  
Supachok Sinchaikul ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Melanoma Cells ◽  
Human Malignant Melanoma
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