Injection of sodium hyaluronate compared with a corticosteroid in the treatment of patients with temporomandibular joint osteoarthritis: clinical effects and computed tomography evaluation of osseous changes

Abstract Background The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome signaling pathway is a highlighted topic in the field of inflammation. However, there is little research on the relationship between the NLRP3 inflammasome pathway and temporomandibular joint osteoarthritis (TMJOA). The aim of this study was to examine the expression of inflammatory mediators related to the NLRP3 inflammasome in the synovial fluid of patients with condylar cartilage degeneration and verify the clinical effects of sodium hyaluronic acid (HA) treatment on TMJOA. Methods Patients diagnosed with temporomandibular joint internal derangement (TMJID) without condylar defects and TMJOA with condylar defects were divided into two groups. There were thirty patients in each group, and inflammatory mediators related to the NLRP3 inflammasome, including interleukin-1 beta (IL-1β), IL-18, NLRP3, and cysteinyl aspartate specific proteinase 1 (CASP1), in synovial fluid were measured by enzyme-linked immunosorbent assay (ELISA). Eighteen patients in the TMJOA group were retested after two HA treatments to evaluate the therapeutic effects of HA. Results IL-1β, IL-18, NLRP3 and CASP1 were all positive in the two groups, and TMJOA patients with condylar defects had higher expression of these molecules than TMJID patients (P < 0.05). IL-1β, IL-18, and NLRP3 were decreased after two HA treatments (P<0.05), but there was no significant difference in CASP1 after two HA injections (P = 0.549). Conclusions The NLRP3 inflammasome signaling pathway may be involved in condylar degeneration. HA could reduce some inflammatory molecules to alleviate inflammation.

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Clinical Outcome of Sodium Hyaluronate Injection into the Superior and Inferior Joint Space for Osteoarthritis of the Temporomandibular Joint Evaluated by Cone-Beam Computed Tomography: A Retrospective Study of 51 Patients and 56 Joints

Medical Science Monitor ◽

10.12659/msm.908821 ◽

2018 ◽

Vol 24 ◽

pp. 5793-5801 ◽

Cited By ~ 3

Author(s):

Haibin Sun ◽

Yi Su ◽

Ning Song ◽

Chunjie Li ◽

Zongdao Shi ◽

...

Keyword(s):

Computed Tomography ◽

Retrospective Study ◽

Clinical Outcome ◽

Temporomandibular Joint ◽

Cone Beam Computed Tomography ◽

Sodium Hyaluronate ◽

Joint Space ◽

Cone Beam

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Does the horizontal condylar angle have a relationship with temporomandibular joint osteoarthritis and condylar position? A cone-beam computed tomography study

Folia Morphologica ◽

10.5603/fm.a2021.0075 ◽

2021 ◽

Author(s):

U. Pamukcu ◽

H. Tetik ◽

I. Peker ◽

B. Altunkaynak ◽

Z. Zafersoy Akarslan

Keyword(s):

Computed Tomography ◽

Temporomandibular Joint ◽

Cone Beam Computed Tomography ◽

Cone Beam ◽

Temporomandibular Joint Osteoarthritis ◽

Condylar Position

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Evaluation of temporomandibular joint disorders using cone beam computed tomography

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20172117 ◽

2017 ◽

Vol 3 (4) ◽

pp. 698

Author(s):

Sonam Kohli ◽

Rahul Krishan Sharma ◽

Anchal Goel ◽

M. K. Sunil

Keyword(s):

Computed Tomography ◽

Temporomandibular Joint ◽

Cone Beam Computed Tomography ◽

Joint Space ◽

Temporomandibular Joint Disorders ◽

Cone Beam ◽

Glenoid Fossa ◽

Significant Difference ◽

Mandibular Fossa ◽

Osseous Changes

Background: The aim of this study was to evaluate efficacy of segmental cone beam computed tomography (CBCT) in detecting bony changes in condyle and thickness of roof of glenoid fossa in temporomandibular joint (TMJ) disorders.Methods: The study group comprised of 10 temporomandibular disorders (TMD) patients of either sex between the age group of 20-60 years diagnosed as TMDs by clinical evaluation using the research diagnostic criteria was considered. After the clinical examination, radiographic investigations were carried out which included digital OPG, transcranial radiograph and CBCT scan. TMJ Evaluation included: (a) bony changes of the condyle (flattening, erosion, sclerosis, osteophytes, resorption); (b) joint space (normal, increased, reduced, bony contact between the condyle and the mandibular fossa); and (c) bony changes of mandibular fossa (normal, sclerosis, erosion, resorption). The radiographic findings were statistically analysed.Results: Significant difference between OPG, transcranial and CBCT were found for the presence of erosion (P =0.000), thickness of roof of glenoid fossa (P =0.000), deformed contour (P =0.001), joint space (P =0.011), subchondral sclerosis (P =0.011), irregularity of articular surface and eminence (P =0.000), flattening (P =0.050). Conclusions: Using CBCT as imaging technique in our study to detect osseous changes in the TMJ was proved to be effective as compared to the conventional radiographic techniques, the results achieved with CBCT was 100%.The results obtained in our study prove to be a full proof one and it seems to promise to go one step closer to detect progression and severity of the osseous changes in the condylar head and mandibular fossa in patients with TMDs.

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