The effect of short-term near-normal blood glucose control on oscillatory potential and macular recovery time in insulin-dependent diabetic patients with long-standing metabolic dysregulation

2009 ◽  
Vol 67 (4) ◽  
pp. 405-408 ◽  
Author(s):  
Kim Frost-Larsen ◽  
Jens Sandahl Christiansen ◽  
Torsten Lauritzen ◽  
Hans-Henrik Parving
1991 ◽  
Vol 14 (2) ◽  
pp. 109-113 ◽  
Author(s):  
P. Cavallo-Perin ◽  
P. Estivi ◽  
L. Boine ◽  
R. Galletti ◽  
G. Pacini ◽  
...  

1981 ◽  
Author(s):  
G Braun ◽  
C Guimont ◽  
Ph Voisin ◽  
D Rousselle ◽  
P Drouin ◽  
...  

A study carried out on 9 insulin-dependent diabetic patients undergoing continuous blood glucose control by means of ex-vivo insulin injection (artificial pancreas - Biostator) has revealed : a relationship between the synthetic capacity of TXA2 (proaggregating molecule) by the platelet and the blood glucose level prior to feed back control. Concurrently, an identical relationship is observed in the case of platelet AMPc levels.After 24 hours of artificial pancreas treatment, it is noted that the greater the effectiveness of the treatment, the greater the increase in the synthetic capacity of TXA2. This observation is confirmed after 48 hours of treatment.Further, the relationship between MDA and Thromboxane B2 synthetized from the same precursory molecules is reversed during treatment.On the basis of these results we may assume that there is a disturbance in the regulation mechanisms of platelet synthesis during diabetes, but that these mechanisms are parthy reversible after artificial pancreas treatment.


1981 ◽  
Author(s):  
Ph Voisin ◽  
D Rouselle ◽  
C Guimont ◽  
P Drouin ◽  
J F Stoltz

Plasma β-thromboglobulin was measured at 0, 24 and 48 hours on 27 healthy subjects and 22 insulin-dependent diabetic patients undergoing a 48-hour artificial pancreas treatment (Biostator).Before treatment all the diabetic patients revealed β-TG levels which were significantly higher than those measured in healthy subjectsOn average, after 24 hours of blood glucose control, β-TG levels in the diabetic patients were not significantly reduced in comparison with the original β-TG levels. In contrast, after 48 hours of blood glucose control, plasma β-TG levels were significantly reduced.As β-TG is a platelet-specific protein, which is considered to be an indicator of the cell’s release reaction, these results suggest that short-term control of blood glucose levels is likely to influence platelet activation in diabetic patients.


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