Evolution Of β-Tg Level In Diabetic Patients Undergoing Artificial Pancreas Treatment

1981 ◽  
Author(s):  
Ph Voisin ◽  
D Rouselle ◽  
C Guimont ◽  
P Drouin ◽  
J F Stoltz
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Healthy Subjects ◽  
Artificial Pancreas ◽  
Blood Glucose Control ◽  
Specific Protein ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Plasma β-thromboglobulin was measured at 0, 24 and 48 hours on 27 healthy subjects and 22 insulin-dependent diabetic patients undergoing a 48-hour artificial pancreas treatment (Biostator).Before treatment all the diabetic patients revealed β-TG levels which were significantly higher than those measured in healthy subjectsOn average, after 24 hours of blood glucose control, β-TG levels in the diabetic patients were not significantly reduced in comparison with the original β-TG levels. In contrast, after 48 hours of blood glucose control, plasma β-TG levels were significantly reduced.As β-TG is a platelet-specific protein, which is considered to be an indicator of the cell’s release reaction, these results suggest that short-term control of blood glucose levels is likely to influence platelet activation in diabetic patients.

Benfluorex and blood glucose control in non insulin-dependent diabetic patients

1991 ◽  
Vol 14 (2) ◽  
pp. 109-113 ◽  
Author(s):  
P. Cavallo-Perin ◽  
P. Estivi ◽  
L. Boine ◽  
R. Galletti ◽  
G. Pacini ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Change In TXB2, MDA And AMP Levels During Artificial Pancreas Treatment On Diabetic Patients

1981 ◽  
Author(s):  
G Braun ◽  
C Guimont ◽  
Ph Voisin ◽  
D Rousselle ◽  
P Drouin ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Ex Vivo ◽  
Artificial Pancreas ◽  
Blood Glucose Control ◽  
Insulin Injection ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Regulation Mechanisms ◽  
Insulin Dependent Diabetic ◽  
Synthetic Capacity

A study carried out on 9 insulin-dependent diabetic patients undergoing continuous blood glucose control by means of ex-vivo insulin injection (artificial pancreas - Biostator) has revealed : a relationship between the synthetic capacity of TXA2 (proaggregating molecule) by the platelet and the blood glucose level prior to feed back control. Concurrently, an identical relationship is observed in the case of platelet AMPc levels.After 24 hours of artificial pancreas treatment, it is noted that the greater the effectiveness of the treatment, the greater the increase in the synthetic capacity of TXA2. This observation is confirmed after 48 hours of treatment.Further, the relationship between MDA and Thromboxane B2 synthetized from the same precursory molecules is reversed during treatment.On the basis of these results we may assume that there is a disturbance in the regulation mechanisms of platelet synthesis during diabetes, but that these mechanisms are parthy reversible after artificial pancreas treatment.

The Assessment of Diabetic Control in Insulin-Independent Patients

1982 ◽  
Vol 27 (1) ◽  
pp. 41-43 ◽  
Author(s):  
A.D.B. Harrower ◽  
G. A. Gilmour
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Good Control ◽  
Diabetic Control ◽  
Aggressive Approach ◽  
Clinical Criteria ◽  
Glucose Levels ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

All diabetics are at risk from the development of the specific and non-specific complications of the disorder. While good control with relative normoglyacemia may be beneficial, most of the emphasis on maintaining stricter blood glucose control has been aimed at the insulin-dependent diabetic. Seventy-four sylphonylurea-treated diabetics were observed for a year and their degree of control assessed and compared using simple clinical criteria, plasma glucose levels and haemoglobin A1cconcentrations. Control was considered good in 55.4 per cent, 16.2 per cent and 14.9 per cent using each criterion respectively. Simple clinical assessment of control is therefore unlikely to achieve normoglycaemia in the majority of such patients. A more wide ranging assessment and a more aggressive approach to therapy may be desirable if better blood glucose control can be shown to produce a reduction in the significant morbidity and mortality in these patients.

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