Treatment of refractory glaucoma using UC3 procedure with HIFU (High Intensity Focused Ultrasound). Prospective series

2013 ◽  
Vol 91 ◽  
pp. 0-0 ◽  
Author(s):  
J ROULAND ◽  
F APTEL
2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Rodolfo Mastropasqua ◽  
Vincenzo Fasanella ◽  
Alessandra Mastropasqua ◽  
Marco Ciancaglini ◽  
Luca Agnifili

The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect relationship. These drawbacks limited the application of cyclodestructive procedures almost exclusively to refractory glaucoma. High-intensity focused ultrasound (HIFU), proposed in the early 1980s and later abandoned because of the complexity and side effects of the procedure, was recently reconsidered in a new approach to destroy the ciliary body. Ultrasound circular cyclocoagulation (UC3), by using miniaturized transducers embedded in a dedicated circular-shaped device, permits to selectively treat the ciliary body in a one-step, computer-assisted, and non-operator-dependent procedure. UC3 shows a high level of safety along with a predictable and sustained IOP reduction in patients with refractory glaucoma. Because of this, the indication of UC3 was recently extended also to naïve-to-surgery patients, thus reconsidering the role and timing of ciliary body ablation in the surgical management of glaucoma. This article provides a review of the most used cycloablative techniques with particular attention to UC3, summarizing the current knowledge about this procedure and future possible developments.


Author(s):  
Natasha Nayak Kolomeyer ◽  
Marlene R. Moster

Abstract Cycloablative or cyclodestructive procedures aim to lower intraocular pressure (IOP) by decreasing the function of the ciliary body and thereby decreasing the rate of aqueous production. Cycloablative procedures were typically used in refractory glaucoma in eyes with poor visual potential; however, more focused energy and targeted destruction of the ciliary body have led to an increase in cyclodestructive treatment options that are now an important adjunct to our surgical armamentarium. This chapter highlights the history of these procedures while focusing on current modalities including transscleral diode cyclophotocoagulation (TSCPC), micropulse transscleral diode cyclophotocoagulation (MP-TSCPC, MicroPulse P3, IRIDEX IQ810 Laser System, Mountain View, CA, USA), and High-Intensity Focused Ultrasound (HIFU). Specifically, this chapter discusses the protocols, indications, results, and complications of each featured procedure.


2016 ◽  
Vol 255 (3) ◽  
pp. 599-605 ◽  
Author(s):  
Giuseppe Giannaccare ◽  
A. Vagge ◽  
C. Gizzi ◽  
A. Bagnis ◽  
S. Sebastiani ◽  
...  

2005 ◽  
Vol 173 (4S) ◽  
pp. 379-380
Author(s):  
James E. Kennedy ◽  
Rowland O. Illing ◽  
Feng Wu ◽  
Gail R. ter Haar ◽  
Rachel R. Phillips ◽  
...  

Praxis ◽  
2016 ◽  
Vol 105 (16) ◽  
pp. 971-977
Author(s):  
Jan Brachlow ◽  
Martin Kälin ◽  
Marco Randazzo ◽  
Beat Förster ◽  
Hubert John

Zusammenfassung. Das Prostatakarzinom zeigt eine hohe Prävalenz und ist daher für die behandelnden Ärzte medizinisch, aber auch gesundheitspolitisch relevant. PSA-Screening senkt die karzinomspezifische Mortalität, ist jedoch aufgrund der hohen Prävalenz mit einer Überdiagnostik verbunden. Dies fordert im Gegenzug einen verantwortungsbewussten Umgang mit dem PSA-Test («smarter screening»). Durch die robotergestützte Prostatektomie steht eine Therapie mit geringer Morbidität zur Behandlung des lokalisierten Prostatakarzinoms zur Verfügung. Das fokale Behandlungskonzept der HIFU (high-intensity focused ultrasound) ist vielversprechend, jedoch noch klinisch experimentell und sollte im Rahmen von Studien angeboten werden. Die Behandlungsmöglichkeiten beim metastasierten Prostatakarzinom wurden entscheidend vervielfältigt. Chemotherapie und die sekundäre Hormontherapie werden voraussichtlich vermehrt in früheren Phasen der Krankheit eine Rolle spielen, wodurch die Therapie für den einzelnen Patienten immer komplexer wird und individuell angepasst werden muss.


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