Expression of the human homolog of discs, large homolog 1 (Drosophila) in normal epithelium, nodule, papilloma and invasive squamous cell carcinoma of larynx

Bronchial dysplasia is the pre-neoplastic lesion recognized for invasive squamous cell carcinoma. The mechanisms leading to invasive squamous cell carcinoma for this lesion are not fully known. Programmed Death-Ligand 1 (PD-L1) expression by the bronchial dysplasia neoplastic epithelium might suggest a response to immunotherapy. The objective of this work is to further characterize PD-L1 and CD8 expression in bronchial dysplasia and bronchial metaplasia compared to normal bronchial epithelium. Immunohistochemical analysis of PD-L1 and CD8 staining were characterized in bronchial dysplasia of 24 patients and correlated with clinical data. We also compared PD-L1 expression in dysplasia samples to 30 normal epithelium and 20 samples with squamous bronchial metaplasia. PD-L1 was never expressed in normal epithelium and in metaplastic epithelium whereas 37.5% of patients with bronchial dysplasia were stained by PD-L1 (p < 0.001). PD-L1 expression was not related to the degree of dysplasia or a medical history of invasive squamous cell carcinoma, while CD8 expression and its localization were related to medical history of squamous cell carcinoma (p = 0.044). Our results show that PD-L1 is expressed in roughly one third of patients with bronchial dysplasia and is not expressed in normal and metaplastic epithelium. This suggests that PD-L1 is expressed in preneoplastic lesions of squamous cell carcinoma.

Download Full-text

Faculty Opinions recommendation of Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1066789.519723 ◽

2007 ◽

Author(s):

Giovanni Scambia

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Epidemiological Studies ◽

Invasive Squamous Cell Carcinoma ◽

Individual Data

Download Full-text

High‐frequency ultrasound in the diagnosis of the spectrum of cutaneous squamous cell carcinoma: Noninvasively distinguishing actinic keratosis, Bowen's Disease, and invasive squamous cell carcinoma

Skin Research and Technology ◽

10.1111/srt.13028 ◽

2021 ◽

Author(s):

An‐Qi Zhu ◽

Li‐Fan Wang ◽

Xiao‐Long Li ◽

Qiao Wang ◽

Ming‐Xu Li ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Actinic Keratosis ◽

High Frequency ◽

Cutaneous Squamous Cell Carcinoma ◽

Invasive Squamous Cell Carcinoma ◽

Bowen’S Disease ◽

High Frequency Ultrasound ◽

Frequency Ultrasound

Download Full-text

Invasive Squamous Cell Carcinoma with Osteomyelitis of the Foot

Journal of the American Podiatric Medical Association ◽

10.7547/14-049.1 ◽

2015 ◽

Vol 105 (4) ◽

pp. 374-376

Author(s):

Morteza Khaladj ◽

Rose-Mary Mbibong ◽

Nisha Shah ◽

Ayesha Mohiuddin ◽

Aqsa Siddiqui

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Chronic Wounds ◽

Squamous Cell Carcinomas ◽

Initial Presentation ◽

Invasive Squamous Cell Carcinoma ◽

The Sun ◽

The Third

Squamous cell carcinomas are often seen on the sun-exposed areas of the skin and are rarely observed on the digits of the foot. However, there have been incidences of squamous cell carcinoma developing in the presence of chronic wounds with osteomyelitis, thus complicating the treatment. We present a patient with osteomyelitis who developed invasive squamous cell carcinoma of the third digit. We conclude that wounds with osteomyelitis may have underlying pathologic abnormalities that are not obvious on initial presentation.

Download Full-text