The role of brain catecholamines in morphine analgesic action in morphine tolerant rats

1970 ◽  
Vol 22 (3) ◽  
pp. 238-239 ◽  
Author(s):  
Yu. P. Vedernikov
Keyword(s):  
Analgesic Action ◽  
Brain Catecholamines

Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level

2005 ◽  
Vol 18 (2) ◽  
pp. 113
Author(s):  
Myung Ha Yoon ◽  
Hong Buem Bae ◽  
Jeong Il Choi ◽  
Seok Jae Kim ◽  
Chang Mo Kim ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtype ◽  
Analgesic Action ◽  
Spinal Level ◽  
Subtype 3

scholarly journals EFFECTS OF NEW PIPERIDINE DERIVATIVES WITH SUBSTITUTIONS IN THE 1ST AND 4TH POSITIONS IN NALOXONE SENSITIVE ANALGESY

2021 ◽  
Vol 19 (5) ◽  
pp. 501-505
Author(s):  
A. A. Vasilyuk ◽  
◽  
V. I. Kozlovsky ◽  
G. S. Akhmetova ◽  
V. K. Yu ◽  
...  
Keyword(s):  
Pain Relief ◽  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Chemical Stimulation ◽  
Analgesic Action ◽  
Preliminary Administration ◽  
Chemical Irritation

Background. Despite the wide arsenal of painkillers, pain relief is an urgent interdisciplinary problem that requires a search for new solutions. Purpose of the study. To establish the role of opioid receptors in the mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23. Material and methods. The studies were carried out on 96 white mice of both sexes weighing 30-40 g. The analgesic effect of the compounds was tested on models of thermal and chemical irritation with preliminary administration of the opioid receptor antagonist naloxone. Results. The pain reactions of mice with models of thermal and chemical stimulation in the AGV-22 / AGV-23 + naloxone and AGV-22 / AGV-23 groups were comparable. Conclusions. The mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23 is not associated with the activation of opioid receptors.

The role of brain catecholamines in the exhibition of muricide induced by nucleus accumbens lesions and the effect of antidepressants in rats

1987 ◽  
Vol 26 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Izaldin M.H. Al-Khatib ◽  
Michihiro Fujiwara ◽  
Katsunori Iwasaki ◽  
Yasufumi Kataoka ◽  
Showa Ueki
Keyword(s):  
Nucleus Accumbens ◽  
Brain Catecholamines

Studies on the Role of Fibrinolysis and Fibrinogen Degradation Products (FDP) in Analgesic Action of Morphine

1972 ◽  
Vol 28 (03) ◽  
pp. 359-366 ◽  
Author(s):  
Włodzimierz Buczko ◽  
Konstanty Wiśniewski
Keyword(s):  
Molecular Weight ◽  
Brain Tissue ◽  
Clinical Effect ◽  
Degradation Products ◽  
Analgesic Action ◽  
Fibrinogen Degradation Products ◽  
The Brain

SummaryThe role of fibrinolysis and FDP in the analgesic action of morphine in mice and rats was studied. It was shown that during activation of blood fibrinolysis, both the accumulation of morphine in the brain tissue of rats and the clinical effect of this drug were increased. Similar results were observed after morphine given simultaneously with FDP obtained in vitro. The data from the analysis of FDP carried out on Sephadex G-25 Fine columns suggest that only FDP of molecular weight of about 10,000 potentiate the action of morphine; smaller peptides decreased the action of this drug.

Indirect role of β2-adrenergic receptors in the mechanism of analgesic action of nonsteroidal antiinflammatory drugs

2010 ◽  
Vol 38 (9) ◽  
pp. 1860-1867 ◽  
Author(s):  
Elif Cadirci ◽  
Halis Suleyman ◽  
Ahmet Hacimuftuoglu ◽  
Zekai Halici ◽  
Fatih Akcay
Keyword(s):  
Adrenergic Receptors ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Analgesic Action ◽  
Antiinflammatory Drugs

scholarly journals The Role of Potassium Channel Activation in Celecoxib-Induced Analgesic Action

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e54797 ◽  
Author(s):  
Yao Mi ◽  
Xuan Zhang ◽  
Fan Zhang ◽  
Jinlong Qi ◽  
Haixia Gao ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Analgesic Action ◽  
Channel Activation
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