scholarly journals Acute Effects of an Oral Nitric Oxide Supplement on Blood Pressure, Endothelial Function, and Vascular Compliance in Hypertensive Patients

2014 ◽  
Vol 16 (7) ◽  
pp. 524-529 ◽  
Author(s):  
Mark Houston ◽  
Laurie Hays
2012 ◽  
Vol 60 (36) ◽  
pp. 9130-9136 ◽  
Author(s):  
Aidilla Mubarak ◽  
Catherine P. Bondonno ◽  
Alex H. Liu ◽  
Michael J. Considine ◽  
Lisa Rich ◽  
...  

2009 ◽  
Vol 11 (12) ◽  
pp. 720-725 ◽  
Author(s):  
Nadya Merchant ◽  
Charles D. Searles ◽  
Anbu Pandian ◽  
Syed T. Rahman ◽  
Keith C. Ferdinand ◽  
...  

2019 ◽  
Vol 20 (3) ◽  
pp. 147032031986889 ◽  
Author(s):  
Piotr Ruszkowski ◽  
Anna Masajtis-Zagajewska ◽  
Michał Nowicki

Background: The aim of this study was to compare the influence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on endothelial function and blood pressure in patients with essential hypertension on long-term angiotensin-converting enzyme inhibitor therapy. Method: The study was designed as a prospective, double-blind, randomised, placebo controlled, crossover clinical trial. Twenty patients with essential hypertension were treated with an angiotensin-converting enzyme inhibitor; the control group included 10 healthy subjects. Hypertensive patients received in random order 80 mg of fluvastatin daily or placebo for 6 weeks. The following parameters were assessed at baseline and after each treatment period: serum lipids, flow-mediated vasodilation, activity of von Willebrand factor, concentration of vascular endothelial growth factor, C-reactive protein and 24-hour blood pressure profile. Results: Hypertensive patients did not differ from healthy subjects with respect to age, body mass and biochemical parameters, with the exception of C-reactive protein, which was higher in hypertensive patients ( P=0.02). After statin therapy, low-density lipoprotein cholesterol ( P<0.0001), C-reactive protein ( P=0.03), von Willebrand factor ( P=0.03) and vascular endothelial growth factor ( P<0.01) decreased and flow-mediated vasodilation improved ( P<0.001). Statins had no significant effect on blood pressure. Conclusions: Statins added to angiotensin-converting enzyme inhibitors may improve endothelial function and ameliorate inflammation independently of blood pressure.


Nitric Oxide ◽  
2018 ◽  
Vol 80 ◽  
pp. 98-107 ◽  
Author(s):  
Eduardo D. Costa ◽  
Josiane F. Silva ◽  
Rosária D. Aires ◽  
Daniela C. Garcia ◽  
Milhem J. Kansaon ◽  
...  

2007 ◽  
Vol 13 (4) ◽  
pp. 256-261
Author(s):  
N. YU. Klimenko ◽  
N. V. Drobotya ◽  
A. A. Kastanyan ◽  
V. V. Kaltykova ◽  
E. Sh. Guseynova

A study of daily blood pressure (BP) dynamics, functional endothelial condition at hypertensive patients in combination with tuberculosis of various localization and estimation of an opportunity of correction of the revealed disturbances during 12-week therapy by the fixed combination of perindopril and indapamide - noliprel-forte (Servier, France) were performed. During research more expressed endothelial dysfunction at hypertensive patients, proceeding on a background of tubercular process in comparison with patients with isolated arterial hypertension was revealed. Therapy by noliprel-forte provided the reliable 24-hour control of BP level, which was accompanied by endothelial function normalization that was shown by improvement of a endothelium-dependent vasodilatation and decrease of a von Willebrand factor level. .


2009 ◽  
Vol 133 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Emmanuel G. Ciolac ◽  
Guilherme V. Guimarães ◽  
Veridiana M. D´Àvila ◽  
Luiz A. Bortolotto ◽  
Egidio L. Doria ◽  
...  

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