scholarly journals A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder

2020 ◽  
Author(s):  
Craig J.R. Sewall ◽  
Jeffrey M. Girard ◽  
John Merranko ◽  
Danella Hafeman ◽  
Benjamin I. Goldstein ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Relationship Quality ◽  
Multilevel Analysis ◽  
Longitudinal Associations

A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder

2020 ◽  
Author(s):  
Craig Sewall ◽  
Jeffrey M. Girard
Keyword(s):  
Bipolar Disorder ◽  
Risk Factor ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Relationship Quality ◽  
Suicide Attempts ◽  
Suicidal Thoughts ◽  
Increased Risk ◽  
Longitudinal Associations ◽  
Suicidal Thoughts And Behaviors

ABSTRACTBackground: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences--reflecting the average relationship quality across time--and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. Methods: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N=413). Relationship quality variables were decomposed into stable (i.e. average) and varying (i.e. recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. Results: Poorer average relationship quality with parents (β= -0.33, 95% Bayesian Highest Density Interval (HDI) [-0.54, -0.11]) or friends (β= -0.33, 95% HDI [-0.55, -0.11]) were longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (β= -0.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (β= -0.06, 95% HDI [-0.15, 0.03]), were also longitudinally associated with increased risk of SI. Worsening recent relationship quality with parents may also be associated with increased risk of suicide attempt (β= -0.13, 95% HDI [-0.29, 0.03]). The effects of certain relationship quality variables were moderated by gender but not age. Conclusions: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents that is may be a time-sensitive indicator of increased risk for SI or suicide attempt.

scholarly journals 0897 Low Stability In Rest Activity Rhythms Is Associated With Higher Suicidal Ideation In Adolescents With Bipolar Disorder

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A360-A361
Author(s):  
Qianyi Chen ◽  
Peter Franzen ◽  
Tina Goldstein ◽  
Sarah Gratzmiller
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Activity Rhythms ◽  
Rest Activity

Longitudinal associations between serum cholesterol levels and suicidal ideation in an older Korean population

2014 ◽  
Vol 152-154 ◽  
pp. 517-521 ◽  
Author(s):  
Jae-Min Kim ◽  
Robert Stewart ◽  
Hee-Ju Kang ◽  
Bo-ok Jeong ◽  
Seon-Young Kim ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Serum Cholesterol ◽  
Korean Population ◽  
Cholesterol Levels ◽  
Longitudinal Associations

Longitudinal associations between childhood sexual abuse-related PTSD symptoms and passive and active suicidal ideation among sexual minority men

2021 ◽  
Vol 122 ◽  
pp. 105353
Author(s):  
Jillian R. Scheer ◽  
Kirsty A. Clark ◽  
Ali Talan ◽  
Cynthia Cabral ◽  
John E. Pachankis ◽  
...  
Keyword(s):  
Sexual Abuse ◽  
Suicidal Ideation ◽  
Childhood Sexual Abuse ◽  
Sexual Minority ◽  
Ptsd Symptoms ◽  
Sexual Minority Men ◽  
Longitudinal Associations ◽  
Minority Men

scholarly journals Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts

2020 ◽  
Author(s):  
Mbemba Jabbi ◽  
Wade Weber ◽  
Jeffrey Welge ◽  
Fabiano Nery ◽  
Maxwell Tallman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Suicide Attempts ◽  
The United States ◽  
Anterior Cingulate ◽  
Type I ◽  
Brain Volumes ◽  
Major Health Problem ◽  
Dorsolateral Prefrontal

ABSTRACTOver 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime, and up to 19% die by suicide. However, the neurobiology of suicide attempts in bipolar disorder remains unclear. Here, we studied the neuroanatomical basis for suicide attempt history in bipolar disorder by measuring gray matter volumes (GMV) to identify differences in brain-volumes in 121 participants with bipolar disorder type I, and healthy participants (n=40). The bipolar group consisted of individuals with suicide attempt history (n=23) and no suicide attempt history (n=58). All participants completed behavioral/diagnostic assessments and MRI measures of GMV. We focused on a predefined frontolimbic circuitry in bipolar disorder versus (vs.) healthy to first identify diagnostic GMV markers and to specifically identify markers for suicide attempt history. We found reduced GMV markers for bipolar diagnosis (i.e., bipolar<healthy) in the anterior cingulate cortex (ACC), and dorsolateral prefrontal cortices (DLPFC). Our observed frontolimbic GMV abnormalities were associated with suicide attempt history and measures of individual variations in current suicidal ideation at the time of scanning. These results identified a frontolimbic-GMV marker for bipolar diagnosis and suicidal behavioral risk tendencies.HighlightsSuicide is a major health problem especially in bipolar disorder but the neurobiological basis for suicide attempts remains obscure. We identified an anterior cingulate and dorsolateral prefrontal cortical volume correlate for suicide attempt history and suicidal ideation and thereby demonstrates a convergent brain marker for suicidal behaviors.

scholarly journals Suicidality in patients with bipolar depression: findings from a lower middle-income country

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S61-S61
Author(s):  
Siqi Xue ◽  
John Hodsoll ◽  
Ameer Bukhsh Khoso ◽  
Muhammad Omair Husain ◽  
Imran B Chaudhry ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Rating Scale ◽  
Bipolar Depression ◽  
Demographic Data ◽  
Middle Income Country ◽  
Income Country ◽  
Middle Income ◽  
Biological Variables ◽  
Lower Middle Income Country

AimsAmong low- and middle-income countries (LMICs), bipolar disorder is recognized as one of the leading causes of disease burden for adults and is associated with marked suicide risk. There are limited data on suicidal ideation in bipolar disorder from LMICs. This study presents cross-sectional data on the prevalence of suicidality and associated patient characteristics among patients with bipolar depression in Pakistan, a lower-middle income country and the fifth most populous country in the world.MethodParticipants were recruited through outpatient psychiatric clinics in between 2016–2019 in Karachi, Lahore, Hyderabad and Rawalpindi between 2016–2019. Participants were aged 18 to 65 years with a known diagnosis of bipolar disorder and currently in a depressive episode. Suicidality was assessed using the suicide item of the 17-item Hamilton Depression Rating Scale (HAM-D) and levels of severity were categorized as absent, mild/moderate, or severe. Biometric data and biomarkers were obtained. Descriptive statistics were used to describe prevalence and proportional odds regression models were applied to establish correlates to suicidal ideation.ResultAmong the 266 participants, 67% indicated suicidality of any level and 16% endorsed severe suicidality. Lower body mass index (BMI) (OR = 0.93, 95% CI = 0.88–0.98), higher HAM-D score (OR = 1.29, 95% CI = 1.16–1.43), lower C-reactive protein (CRP) level (OR = 0.53, 95% CI = 0.40–0.70), and increased number of inpatient hospitalizations (OR = 1.16, 95% CI = 1.03–1.31) were identified as significant predictors of suicidality in the fully adjusted regression model. No patient demographic data, including age, gender, marital status, socioeconomic status, and years of education were associated with severity of suicidality.ConclusionThere exists a high prevalence of suicidal ideation among patients with bipolar depression in Pakistan. Our findings add to the limited literature on suicidality in bipolar disorder in the LMIC context and suggest roles of biological variables such as BMI and CRP level in predicting suicidal ideation and potentially suicidal behaviours in bipolar depression. More studies are needed to see whether such findings can be replicated in other similar LMIC settings, and to explore potential physiological pathways linking BMI, inflammatory biomarkers and suicidality in bipolar disorder.

Suicidal Ideation in Bipolar Disorder: The Relation with Clinical and Sociodemographic Variables

2021 ◽  
Author(s):  
Renata Reis Lage ◽  
Rafael de Assis da Silva ◽  
Marcelo Baggi Tancini ◽  
Antonio Egidio Nardi ◽  
Daniel C. Mograbi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Sociodemographic Variables
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