A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder

2020 ◽  
Author(s):  
Craig Sewall ◽  
Jeffrey M. Girard
Keyword(s):  
Bipolar Disorder ◽  
Risk Factor ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Relationship Quality ◽  
Suicide Attempts ◽  
Suicidal Thoughts ◽  
Increased Risk ◽  
Longitudinal Associations ◽  
Suicidal Thoughts And Behaviors

ABSTRACTBackground: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences--reflecting the average relationship quality across time--and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. Methods: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N=413). Relationship quality variables were decomposed into stable (i.e. average) and varying (i.e. recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. Results: Poorer average relationship quality with parents (β= -0.33, 95% Bayesian Highest Density Interval (HDI) [-0.54, -0.11]) or friends (β= -0.33, 95% HDI [-0.55, -0.11]) were longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (β= -0.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (β= -0.06, 95% HDI [-0.15, 0.03]), were also longitudinally associated with increased risk of SI. Worsening recent relationship quality with parents may also be associated with increased risk of suicide attempt (β= -0.13, 95% HDI [-0.29, 0.03]). The effects of certain relationship quality variables were moderated by gender but not age. Conclusions: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents that is may be a time-sensitive indicator of increased risk for SI or suicide attempt.

scholarly journals Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts

2020 ◽  
Author(s):  
Mbemba Jabbi ◽  
Wade Weber ◽  
Jeffrey Welge ◽  
Fabiano Nery ◽  
Maxwell Tallman ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Suicide Attempts ◽  
The United States ◽  
Anterior Cingulate ◽  
Type I ◽  
Brain Volumes ◽  
Major Health Problem ◽  
Dorsolateral Prefrontal

ABSTRACTOver 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime, and up to 19% die by suicide. However, the neurobiology of suicide attempts in bipolar disorder remains unclear. Here, we studied the neuroanatomical basis for suicide attempt history in bipolar disorder by measuring gray matter volumes (GMV) to identify differences in brain-volumes in 121 participants with bipolar disorder type I, and healthy participants (n=40). The bipolar group consisted of individuals with suicide attempt history (n=23) and no suicide attempt history (n=58). All participants completed behavioral/diagnostic assessments and MRI measures of GMV. We focused on a predefined frontolimbic circuitry in bipolar disorder versus (vs.) healthy to first identify diagnostic GMV markers and to specifically identify markers for suicide attempt history. We found reduced GMV markers for bipolar diagnosis (i.e., bipolar<healthy) in the anterior cingulate cortex (ACC), and dorsolateral prefrontal cortices (DLPFC). Our observed frontolimbic GMV abnormalities were associated with suicide attempt history and measures of individual variations in current suicidal ideation at the time of scanning. These results identified a frontolimbic-GMV marker for bipolar diagnosis and suicidal behavioral risk tendencies.HighlightsSuicide is a major health problem especially in bipolar disorder but the neurobiological basis for suicide attempts remains obscure. We identified an anterior cingulate and dorsolateral prefrontal cortical volume correlate for suicide attempt history and suicidal ideation and thereby demonstrates a convergent brain marker for suicidal behaviors.

scholarly journals The effect of sexual abuse and dissociation on suicide attempt

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Silje Støle Brokke ◽  
Thomas Bjerregaard Bertelsen ◽  
Nils Inge Landrø ◽  
Vegard Øksendal Haaland
Keyword(s):  
Sexual Abuse ◽  
Risk Factor ◽  
Suicide Attempt ◽  
Indirect Effects ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Suicidal Thoughts ◽  
Dissociative Experiences ◽  
Self Harm

Abstract Background Suicide attempt is the most predictive risk factor of suicide. Trauma – especially sexual abuse – is a risk factor for suicide attempt and suicide. A common reaction to sexual abuse is dissociation. Higher levels of dissociation are linked to self-harm, suicide ideation, and suicide attempt, but the role of dissociation in suicidal behavior is unclear. Methods In this naturalistic study, ninety-seven acute psychiatric patients with suicidal ideation, of whom 32 had experienced sexual abuse, were included. Suicidal behaviour was assessed with The Columbia suicide history form (CSHF). The Brief trauma questionnaire (BTQ) was used to identify sexual abuse. Dissociative symptoms were assessed with Dissociative experiences scale (DES). Results Patients who had experienced sexual abuse reported higher levels of dissociation and were younger at onset of suicidal thoughts, more likely to self-harm, and more likely to have attempted suicide; and they had made more suicide attempts. Mediation analysis found dissociative experiences to significantly mediate a substantive proportion of the relationship between sexual abuse and number of suicide attempts (indirect effects = 0.17, 95% CI = 0.05, 0.28, proportion mediated = 68%). Dissociative experiences significantly mediated the role of sexual abuse as a predictor of being in the patient group with more than four suicide attempts (indirect effects = 0.11, 95% CI = 0.02, 0.19, proportion mediated = 34%). Conclusion The results illustrate the importance of assessment and treatment of sexual abuse and trauma-related symptoms such as dissociation in suicide prevention. Dissociation can be a contributing factor to why some people act on their suicidal thoughts.

scholarly journals Contributions of childhood peer victimization and/or maltreatment to young adult anxiety, depression, and suicidality: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Melissa Macalli ◽  
Massimiliano Orri ◽  
Christophe Tzourio ◽  
Sylvana M. Côté
Keyword(s):  
Mental Health ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Peer Victimization ◽  
Childhood Maltreatment ◽  
Mental Health Problems ◽  
Increased Risk ◽  
Anxiety Depression ◽  
Suicidal Thoughts And Behaviors ◽  
Parental Maltreatment

Abstract Background Childhood maltreatment and peer victimization are major risk factors for depression and suicidal behavior. Furthermore, childhood maltreatment increases the risk of peer victimization. Our objective was to distinguish between the contributions of parental maltreatment and peer victimization to the development of mental health problems in young adulthood. Specifically, we tested whether peer victimization alone or in combination with parental maltreatment before 18 years old was associated with anxiety, depression, and suicidal thoughts and behaviors at age 21 years. Methods We analyzed data collected from questionnaires administered in the i-Share (Internet-based Students’ Health ResearchEnterprise) study in France from February 2013 to September 2019 (N = 2271 participants). We performed multinomial and binary logistic regression analyses to assess the single and combined contributions of childhood peer victimization and parental maltreatment to anxiety, depression, and suicidality in adulthood. Results Nearly one third of students (28.8%) reported at least one mental health problem; 29.8% reported peer victimization alone; 7.5% reported parental maltreatment alone; and 10.3% reported both parental maltreatment and victimization. In multivariate models, compared to participants that did not experience maltreatment or peer victimization, those that experienced peer victimization alone were more likely to report anxiety (adjusted odds ratio [aOR]: 1.90; 95% CI: 1.50–2.40), depression (aOR: 1.95; 95% CI: 1.46–2.60), or suicidal ideation, without (aOR: 1.62; 95% CI: 1.26–2.09) or with a suicide attempt (aOR: 2.70; 95% CI: 1.51–4.85). Similar associations were observed for participants that experienced maltreatment alone. Participants that experienced both maltreatment and peer victimization were at increased risk of depression (aOR: 2.63; 95% CI: 1.79–3.86) and suicidal ideation, with (aOR: 9.19; 95% CI: 4.98–16.92) and without a suicide attempt (aOR: 2.64; 95% CI: 1.86–3.76). Conclusions Separate and combined exposures to parental maltreatment and peer victimization in childhood or adolescence were associated with increased risks of anxiety, depression, and suicidal behaviors. Peer victimization appeared to play a specific role in mental health disorders that were not otherwise explained by polyvictimization. Currently, peer victimization is a frequent, but avoidable type of child abuse; therefore, these findings have implications for policies for preventing and dealing with peer victimization.

Onset of panic disorder and suicide attempts

1990 ◽  
Vol 5 (6) ◽  
pp. 339-342
Author(s):  
JP Lepine ◽  
JM Chignon ◽  
M Teherani
Keyword(s):  
Suicidal Ideation ◽  
General Population ◽  
Panic Disorder ◽  
Suicide Attempt ◽  
Panic Attack ◽  
Attempted Suicide ◽  
Suicide Attempts ◽  
Skewed Distribution ◽  
Lifetime Prevalence ◽  
Increased Risk

SummaryIn a study of the general population, Weissman et al (1989), found that panic disorder is associated with an increased risk of suicide attempt. We estimated the lifetime prevalence of suicidal ideations or suicide attempts in 100 consecutive referrals for treatment of panic disorder. Sixty per cent of these patients had had suicidal ideation and 42% had attempted suicide during their lifetime. With regard to the season of onset of panic attack, we found a very skewed distribution of first panic in late spring or summer. Furthermore, patients who had their first attack in spring or summer had a higher rate of suicidal ideation and an increased risk of suicide attempt.

scholarly journals Sleep Duration Is Closely Associated with Suicidal Ideation and Suicide Attempt in Korean Adults: A Nationwide Cross-Sectional Study

2021 ◽  
Vol 18 (11) ◽  
pp. 5594
Author(s):  
Yujin Ko ◽  
Jieun Moon ◽  
Sangsoo Han
Keyword(s):  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Sleep Duration ◽  
Suicide Attempts ◽  
Sleep Problems ◽  
Survey Methods ◽  
Self Report ◽  
Short Sleep Duration ◽  
Sampling Weights ◽  
Increased Risk

Introduction: Suicidal ideation and suicide attempts are major risk factors for suicidal death, and sleep problems are associated with an increased risk for mental disorders. We investigated the relationship between sleep duration and suicidal ideation and suicide attempts in a representative sample of the Korean general population from a nationwide survey. Methods: We analyzed data collected from the Korea National Health and Nutrition Examination Survey VI and VII (2013–2018). Suicidal ideation was identified via self-report, and we accessed suicide attempt history. Sleep duration was divided into three categories: short sleep duration (SSD) (≤5 h), normal sleep duration (NSD) (>5 and <9 h), and long sleep duration (LSD) (≥9 h). Sampling weights were applied to obtain estimates for the general Korean population. Results: Overall, 4015 (12.0%), 25,609 (76.5%), and 3857 (11.5%) participants were in the SSD, NSD, and LSD groups, respectively. Among these groups, 7.2%, 2.8%, and 3.3% reported suicidal ideation; while 1.2%, 0.4%, and 0.7% reported a history of suicide attempts. Multiple regression analyses revealed that SSD was significantly more strongly associated with suicidal ideation (adjusted odds ratio (AOR) 1.46, p < 0.001) and attempts (AOR 2.05, p = 0.003) than NSD. No association was found between LSD and suicidal ideation/attempts. Conclusion: Sleep duration is significantly associated with suicidal behavior, and SSD was particularly closely related with an increased risk for suicidal ideation and suicide attempt. Clinicians should carefully consider sleep duration in suicidal patients.

scholarly journals Sleep Duration is Closely Associated with Suicidal Ideation and Suicide Attempt in Korean Adults: A Nationwide Cross-sectional Study

2021 ◽  
Author(s):  
Yujin Ko ◽  
Ji Eun Moon ◽  
Sangsoo Han
Keyword(s):  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Sleep Duration ◽  
Suicide Attempts ◽  
Sleep Problems ◽  
Self Report ◽  
Short Sleep Duration ◽  
Sampling Weights ◽  
Cross Sectional ◽  
Increased Risk

Abstract Introduction: Suicidal ideation and suicide attempts are major risk factors for suicidal death, and sleep problems are associated with an increased risk for mental disorders. We investigated the relationship between sleep duration and suicidal ideation and suicide attempts in a representative sample of the Korean general population from a nationwide survey.Methods: We analyzed data collected from the Korea National Health and Nutrition Examination Survey VI and VII (2013–2018). Suicidal ideation was identified via self-report and we accessed suicide attempt history. Sleep duration was divided into three categories: short sleep duration (SSD) (≤5 h), normal sleep duration (NSD) (>5 and <9 h), and long sleep duration (LSD) (≥9 h). Sampling weights were applied to obtain estimates for the general Korean population.Results: Overall, 4015 (12.0%), 25,609 (76.5%), and 3857 (11.5%) participants were in the SSD, NSD, and LSD groups, respectively. Among these groups, 7.2%, 2.8%, and 3.3% reported suicidal ideation, 1.2%, 0.4%, and 0.7% reported a history of suicide attempts. Multiple regression analyses revealed that SSD was significantly more strongly associated with suicidal ideation (adjusted odds ratio [AOR] 1.46, p < 0.001) and attempts (AOR 2.05, p = 0.003) than NSD. No association was found between LSD and suicidal ideation/attempts. Conclusion: Sleep duration is significantly associated with suicidal behavior, and SSD was particularly closely related with an increased risk for suicidal ideation and suicide attempt. Clinicians should carefully consider sleep duration in suicidal patients.

scholarly journals Psychopathy and Suicidal Thoughts and Behaviors Revisited: Results From a Statewide Population of Institutionalized Youth

2018 ◽  
Vol 63 (6) ◽  
pp. 874-895 ◽  
Author(s):  
Mark H. Heirigs ◽  
Matt DeLisi ◽  
Bryanna Fox ◽  
Katie Dhingra ◽  
Michael G. Vaughn
Keyword(s):  
Suicidal Ideation ◽  
Juvenile Offenders ◽  
Juvenile Justice ◽  
Suicide Attempts ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Psychopathic Personality ◽  
Incarcerated Youth ◽  
Suicidal Thoughts ◽  
Suicidal Thoughts And Behaviors

Suicide is the leading cause of death for incarcerated youth, and up to half of all juveniles in confinement experience suicidal ideation in addition to other psychopathology, including psychopathic personality features. Unfortunately, limited research has investigated the psychopathy–suicidality link among juvenile delinquents and using newer psychopathy measures. Based upon a statewide population of incarcerated juvenile offenders, we found that psychopathy was a significant risk factor for suicidal ideation and lifetime suicide attempts, but the latter relationship was attenuated by lifetime depression diagnosis. In addition, certain affective psychopathic features such as Stress Immunity conferred protection against suicidality, whereas behavioral and lifestyle components including Carefree Nonplanfulness, Blame Externalization, and Rebellious Nonconformity were positively linked to suicidal thoughts among the youth offenders. As these risk factors are routinely screened for in juvenile justice settings, this study’s findings have considerable implications to applied practice and prevention among juvenile justice involved youth.

scholarly journals Suicidal Thoughts, Behaviors, and Event-Related Potentials: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Austin J. Gallyer ◽  
Sean P. Dougherty ◽  
Kreshnik Burani ◽  
Brian J. Albanese ◽  
Thomas E. Joiner ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Suicide Risk ◽  
Suicide Attempts ◽  
Meta Analysis ◽  
Event Related Potentials ◽  
Small Sample ◽  
Effect Sizes ◽  
Suicidal Thoughts ◽  
Related Potentials ◽  
Suicidal Thoughts And Behaviors

AbstractBackgroundSuicidal thoughts and behaviors (STBs) are thought to be the result, at least in part, of abnormalities in various neural systems. Event-related potentials (ERPs) are a useful method for studying neural activity and can be leveraged to study neural deficits related to STBs; however, it is unknown how effective ERPs are at differentiating various STB groups. The present meta-analysis examined how well ERPs can differentiate (a) those with and without suicidal ideation, (b) those with and without suicide attempts, (c) those with different levels of suicide risk, and (d) differences between those with suicide attempts versus those with suicidal ideation only.MethodOur meta-analysis included 208 effect sizes from 2,517 participants from 27 studies. We used a random-effects meta-analysis using a restricted maximum likelihood estimator with robust variance estimation.ResultsOur qualitative review found that for each ERP and STB combination, the literature is highly mixed. Our meta-analyses found a small-to-moderate relationship between ERPs and suicidal ideation, suicide attempt, suicide risk, and differences in ERPs between those with suicide attempts versus those with suicidal ideation only. We also found evidence that the literature may be suffering from small-sample bias and poor statistical power.ConclusionsOur results suggest that ERPs may complement other approaches, such as fMRI, in the study of the neurobiology of individuals with STBs. However, the current literature is severely underpowered to detect the effect sizes estimated in this meta-analysis. We recommend large-scale collaboration and improvements in measurement practices to combat the issues in this literature.

Attachment Organization in Suicide Prevention Research

Crisis ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Amanda Venta ◽  
Carla Sharp
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Interpersonal Relationships ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Critical Role ◽  
Self Report ◽  
Future Research ◽  
Self Harm

Background: Identifying risk factors for suicide-related thoughts and behaviors (SRTB) is essential among adolescents in whom SRTB remain a leading cause of death. Although many risk factors have already been identified, influential theories now suggest that the domain of interpersonal relationships may play a critical role in the emergence of SRTB. Because attachment has long been seen as the foundation of interpersonal functioning, we suggest that attachment insecurity warrants attention as a risk factor for SRTB. Aims: This study sought to explore relations between attachment organization and suicidal ideation, suicide attempts, and self-harm in an inpatient adolescent sample, controlling for demographic and psychopathological covariates. Method: We recruited 194 adolescents from an inpatient unit and assigned them to one of four attachment groups (secure, preoccupied, dismissing, or disorganized attachment). Interview and self-report measures were used to create four variables reflecting the presence or absence of suicidal ideation in the last year, single lifetime suicide attempt, multiple lifetime suicide attempts, and lifetime self-harm. Results: Chi-square and regression analyses did not reveal significant relations between attachment organization and SRTB, although findings did confirm previously established relations between psychopathology and SRTB, such that internalizing disorder was associated with increased self-harm, suicide ideation, and suicide attempt and externalizing disorder was associated with increased self-harm. Conclusion: The severity of this sample and methodological differences from previous studies may explain the nonsignificant findings. Nonsignificant findings may indicate that the relation between attachment organization and SRTB is moderated by other factors that should be explored in future research.

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