scholarly journals Polygenic risks for joint developmental trajectories of internalizing and externalizing problems: findings from the ALSPAC cohort

2021 ◽  
Author(s):  
Lydia Gabriela Speyer ◽  
Samuel Neaves ◽  
Hildigunnur Anna Hall ◽  
Gibran Hemani ◽  
Michael Vincent Lombardo ◽  
...  
Keyword(s):  
Externalizing Problems ◽  
Developmental Trajectories ◽  
Internalizing And Externalizing Problems ◽  
Internalizing And Externalizing

scholarly journals Polygenic Risks for Joint Developmental Trajectories of Internalizing and Externalizing Problems: Findings from the ALSPAC Cohort

2021 ◽  
Author(s):  
Lydia Gabriela Speyer ◽  
Samuel Neaves ◽  
Hildigunnur Anna Hall ◽  
Gibran Hemani ◽  
MIchael Lombardo ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Externalizing Problems ◽  
Maternal Mental Health ◽  
Developmental Trajectories ◽  
Externalizing Symptoms ◽  
Internalizing And Externalizing Problems ◽  
Shared Risk ◽  
Internalizing And Externalizing ◽  
Internalizing And Externalizing Symptoms

Background: Joint developmental trajectories of internalizing and externalizing problems show considerable heterogeneity; however, this can be parsed into a small number of meaningful subgroups. Doing so offered insights into risk factors that lead to different patterns of internalizing/externalizing trajectories. However, despite both domains of problems showing strong heritability, no study has yet considered genetic risks as predictors of joint internalizing/externalizing problem trajectories. Methods: Using parallel process latent class growth analysis, we estimated joint developmental trajectories of internalizing and externalizing difficulties assessed across ages 4 to 16 using the Strengths and Difficulties Questionnaire. Multinomial logistic regression was used to evaluate a range of demographic, perinatal, maternal mental health, and child and maternal polygenic predictors of group membership. Participants included 11049 children taking part in the Avon Longitudinal Study of Parents and Children. Polygenic data was available for 7127 children and 6836 mothers.Results: Five distinct classes were identified: Unaffected, Moderate Externalizing Symptoms, High Externalizing Symptoms, Moderate Internalizing and Externalizing Symptoms and High Internalizing and Externalizing Symptoms. Male sex, lower maternal age, maternal mental health problems, maternal smoking during pregnancy, higher child polygenic risk scores for ADHD as well as lower polygenic scores for IQ distinguished affected classes from the unaffected class.Conclusions: While affected classes could be relatively well separated from the unaffected class, phenotypic and polygenic predictors were limited in their ability to distinguish between different affected classes. Thus, results add to existing evidence that internalizing and externalizing problems have mostly shared risk factors.

The trajectories of child’s internalizing and externalizing problems, social competence and adolescent self-reported problems in a Finnish normal population sample

2014 ◽  
Vol 35 (6) ◽  
pp. 561-579 ◽  
Author(s):  
Marie Korhonen ◽  
Ilona Luoma ◽  
Raili K. Salmelin ◽  
Mika Helminen ◽  
Riittakerttu Kaltiala-Heino ◽  
...  
Keyword(s):  
Social Competence ◽  
School Psychologists ◽  
Internalizing Problems ◽  
Externalizing Problems ◽  
Normal Population ◽  
Population Sample ◽  
Self Report ◽  
Internalizing And Externalizing Problems ◽  
High Level ◽  
Internalizing And Externalizing

Group-based modeling techniques are increasingly used in developmental studies to explore the patterns and co-occurrence of internalizing and externalizing problems. Social competence has been found to reciprocally influence internalizing and externalizing problems, but studies on its associations with different patterns of these problems are scarce. Using data from a Finnish longitudinal normal population sample, trajectories of internalizing and externalizing problems were formed using the Child Behavior Checklist completed by the mother at the child’s age of 4- to 5-years-old, 8- to 9-years-old, and 16- to 17-years-old ( N = 261). The results indicate that adolescent’s self-reported internalizing and externalizing problems based on the Youth Self Report were associated with the trajectories of internalizing and externalizing problems. Social competence both in early childhood and in adolescence was poorer among children with chronic internalizing problems and among those with adolescent-onset externalizing problems. One-third of the children who had a chronically high level of internalizing problems had an initially high but decreasing level of externalizing problems, while 33% of the adolescents with adolescent-onset externalizing problems had a chronically high level of internalizing problems. School psychologists are encouraged to screen for internalizing problems from children with behavioral, academic or social problems.

scholarly journals Associations of Family Functioning and Social Support With Psychopathology in Children of Mentally Ill Parents: Multilevel Analyses From Different Rating Perspectives

2021 ◽  
Vol 12 ◽  
Author(s):  
Marlit Sell ◽  
Claus Barkmann ◽  
Bonnie Adema ◽  
Anne Daubmann ◽  
Reinhold Kilian ◽  
...  
Keyword(s):  
Social Support ◽  
Family Functioning ◽  
Mentally Ill ◽  
Externalizing Problems ◽  
Child Psychopathology ◽  
Multilevel Analyses ◽  
Cross Sectional ◽  
Internalizing And Externalizing Problems ◽  
Internalizing And Externalizing ◽  
Mentally Ill Parents

Offspring of mentally ill parents is at heightened risk for psychological symptoms. The identification of environmental factors that predict their mental health is crucial for the development of preventive and therapeutic measures. In the current study, we addressed the combined role of family functioning and social support by taking mentally ill patients’, their partners’, and children’s perspectives into account. The cross-sectional sample included n=195 families (195 patients, 127 partners, and 295 children). Family members completed questionnaires related to family functioning, social support as well as parental and child psychopathology. We conducted multilevel analyses to investigate the associations with internalizing and externalizing problems in children. Family functioning and social support were significantly associated with child internalizing and externalizing problems. However, results varied depending on the rating perspective. We found significant interaction effects of family functioning and social support on child psychopathology. The findings point to the importance of family functioning and social support as potential targets for interventions. Findings should be replicated in future longitudinal studies.

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