Delayed Heart Rate Recovery after Exercise Predicts Development of Metabolic Syndrome: A Retrospective Cohort Study

Abstract Purpose: Multiple studies have demonstrated an obesity paradox such that obese septic patients have a lower mortality rate and a relatively favorable prognosis. However, less is known on the association between abdominal obesity and short-term mortality in patients with sepsis. We conducted this study to determine whether the obesity-related survival benefit remains among abdominal obese patients.Methods: A retrospective cohort study was conducted using data derived from the Medical Information Mart for Intensive Care IV database. Septic patients (≥18 years) with or without abdominal obesity of first intensive care units (ICU) admission in the database were enrolled. The primary outcome was mortality within 28 days of ICU admission and multivariable logistic regression analyses were employed to assess any association between abdominal obesity and the outcome variable.Results: A total of 21534 patients were enrolled finally, the crude 28-day mortality benefit after ICU admission was not observed in patients with abdominal obesity (15.8% vs. 15.3%, p=0.32). In the extended multivariable logistic models, the odds ratio (OR) of abdominal obesity was significantly inversed after incorporating metabolic variables into the logistic model (OR range 1.094-2.872, p = 0.02). The subgroup analysis showed interaction effects in impaired fasting blood glucose/diabetes and metabolic syndrome subgroups (P = 0.001 and <0.001, respectively). In the subgroups of blood pressure, high-density lipoprotein cholesterol, and triglyceride level, no interaction was detected in the association between abdominal obesity and mortality. After propensity score matching, 6523 pairs of patients were selected. The mortality significantly higher in the abdominal obesity group (17.0% vs. 14.8%, p = 0.015). Notably, the non-abdominal obese patients were weaned off vasopressors and mechanical ventilation more quickly than those in the abdominal obesity group (vasopressor‑free days on day 28 of 27.0 vs. 26.8, p < 0.001; ventilation-free days on day 28 of 26.7 vs. 25.6, p < 0.001).Conclusion: Abdominal obesity was associated with increased risk of adjusted sepsis-related mortality within 28 days after ICU admission and was partially mediated through metabolic syndrome components.

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Retrospective cohort study to assess the prevalence of different factors of metabolic syndrome in central centrifugal cicatricial alopecia patients

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2018.05.979 ◽

2018 ◽

Vol 79 (3) ◽

pp. AB246

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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Influence of Occupational Type and Lifestyle Risk Factors on Prevalence of Metabolic Syndrome among Male Workers: A Retrospective Cohort Study

Korean Journal of Adult Nursing ◽

10.7475/kjan.2016.28.2.180 ◽

2016 ◽

Vol 28 (2) ◽

pp. 180 ◽

Cited By ~ 3

Author(s):

So Hui Kang ◽

Seon Young Hwang

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Lifestyle Risk Factors ◽

Lifestyle Risk ◽

Male Workers

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Association of metabolic syndrome with glioblastoma: a retrospective cohort study and review

Neuro-Oncology Practice ◽

10.1093/nop/npaa011 ◽

2020 ◽

Vol 7 (5) ◽

pp. 541-548

Author(s):

Lisa R Rogers ◽

Quinn T Ostrom ◽

Julia Schroer ◽

Jaime Vengoechea ◽

Li Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Overall Survival ◽

Risk Factor ◽

Cohort Study ◽

General Population ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Laboratory Data ◽

The Metabolic Syndrome ◽

Clinical Records

Abstract Background Metabolic syndrome is identified as a risk factor for the development of several systemic cancers, but its frequency among patients with glioblastoma and its association with clinical outcomes have yet to be determined. The aim of this study was to investigate metabolic syndrome as a risk factor for and affecting survival in glioblastoma patients. Methods A retrospective cohort study, consisting of patients with diagnoses at a single institution between 2007 and 2013, was conducted. Clinical records were reviewed, and clinical and laboratory data pertaining to 5 metabolic criteria were extrapolated. Overall survival was determined by time from initial surgical diagnosis to date of death or last follow-up. Results The frequency of metabolic syndrome among patients diagnosed with glioblastoma was slightly greater than the frequency of metabolic syndrome among the general population. Within a subset of patients (n = 91) receiving the full schedule of concurrent radiation and temozolomide and adjuvant temozolomide, median overall survival was significantly shorter for patients with metabolic syndrome compared with those without. In addition, the presence of all 5 elements of the metabolic syndrome resulted in significantly decreased median survival in these patients. Conclusions We identified the metabolic syndrome at a slightly higher frequency in patients with diagnosed glioblastoma compared with the general population. In addition, metabolic syndrome with each of its individual components is associated with an overall worse prognosis in patients receiving the standard schedule of radiation and temozolomide after adjustment for age.

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Recurrent pre-eclampsia in women with metabolic syndrome and low plasma volume: a retrospective cohort study

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/1471-0528.13737 ◽

2015 ◽

Vol 122 (13) ◽

pp. 1773-1780 ◽

Cited By ~ 7

Author(s):

E Stekkinger ◽

RR Scholten ◽

WM Heidema ◽

MEA Spaanderman

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Plasma Volume ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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Risk Assessment of Metabolic Syndrome Using Transported Estimates in Retrospective Cohort Study

Japanese Journal of Biometrics ◽

10.5691/jjb.30.93 ◽

2009 ◽

Vol 30 (2) ◽

pp. 93-104

Author(s):

Noriko Ishida ◽

Shinichiro Ichimaru ◽

Ayumi Hida ◽

Midori Soda ◽

Tsuyoshi Nakamura ◽

...

Keyword(s):

Risk Assessment ◽

Metabolic Syndrome ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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Faculty Opinions recommendation of Maternal pulse pressure at admission is a risk factor for fetal heart rate changes after initial dosing of a labor epidural: a retrospective cohort study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718020693.793487312 ◽

2013 ◽

Author(s):

Barbara M Scavone ◽

Jennifer Hofer

Keyword(s):

Heart Rate ◽

Risk Factor ◽

Cohort Study ◽

Pulse Pressure ◽

Retrospective Cohort Study ◽

Fetal Heart Rate ◽

Retrospective Cohort ◽

Fetal Heart ◽

Labor Epidural

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Original Article (Clinical Investigation) Enhanced Prediction of Renal Function Decline by Replacing Waist Circumference With “a Body Shape Index (Absi)” in Diagnosing Metabolic Syndrome: A Retrospective Cohort Study in Japan

10.21203/rs.3.rs-777667/v1 ◽

2021 ◽

Author(s):

Daiji Nagayama ◽

Kentaro Fujishiro ◽

Shinichi Tsuda ◽

Yasuhiro Watanabe ◽

Takashi Yamaguchi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Renal Function ◽

Cohort Study ◽

Waist Circumference ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Body Shape ◽

Shape Index ◽

Renal Function Decline ◽

A Body Shape Index

Abstract Background: Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is conventionally evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. We aimed to examine whether replacing WC with “A Body Shape Index (ABSI)”, an abdominal obesity index, in MetS diagnosis is useful for predicting renal function decline (RFD). Methods: A retrospective cohort study was conducted in 5438 Japanese urban residents (median age 48 years) who participated in a public health screening program for 4 consecutive years. Systemic arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and high CAVI was defined as CAVI ≥ 9.0. The predictability of the occurrence of RFD (eGFR < 60 mL/min/1.73m 2 ) by replacing high WC with high ABSI (ABSI ≥ 0.080) was examined using three sets of MetS diagnostic criteria: Japanese, International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Results: In Japanese and NCEP-ATPIII criteria, MetS diagnosed using ABSI (ABSI-MetS) was associated with significantly higher age-adjusted CAVI compared to non-MetS, whereas MetS diagnosed using WC (WC-MetS) showed no association. Kaplan-Meier analysis of the rate of new-onset RFD over 4 years (total 8.7%) showed remarkable higher rate in subjects with ABSIMetS than in those without (log-rank test p <0.001), but almost no difference between subjects with and without WC-MetS ( p = 0.014-0.617). In Cox analysis including gender, high CAVI and low-density lipoprotein‒cholesterol ≥140 mg/dL as confounders, only ABSI-MetS diagnosed by Japanese criteria contributed independently to the occurrence of RFD (HR = 1.41, p = 0.011). High CAVI was also an independent contributor to the occurrence of RFD. In a subanalysis, ABSI-MetS diagnosed by Japanese criteria contributed significantly to the occurrence of RFD regardless of age or gender, while WC-MetS by Japanese criteria contributed significantly only in older women. Conclusion: In this study, replacing WC with ABSI in MetS diagnostic criteria more efficiently predicted subjects at risk of RFD and arterial stiffening. Further studies are needed to confirm whether MetS diagnosed using ABSI also predicts CVD.

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