Protein SUMOylation is Involved in Cell-cycle Progression and Cell Morphology in Giardia lamblia

2016 ◽  
Vol 64 (4) ◽  
pp. 491-503 ◽  
Author(s):  
Bruno M. Di Genova ◽  
Richard C. da Silva ◽  
Júlia P.C. da Cunha ◽  
Pablo R. Gargantini ◽  
Renato A. Mortara ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Morphology ◽  
Giardia Lamblia ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Protein Sumoylation

scholarly journals Cell morphology and nucleoid dynamics in dividing D. radiodurans

2019 ◽  
Author(s):  
Kevin Floc’h ◽  
Françoise Lacroix ◽  
Pascale Servant ◽  
Yung-Sing Wong ◽  
Jean-Philippe Kleman ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Single Molecule ◽  
Cell Morphology ◽  
Cell Cycle Progression ◽  
Deinococcus Radiodurans ◽  
Morphological Changes ◽  
Cycle Progression ◽  
Chromosomal Arrangement ◽  
Tightly Coupled ◽  
Large Spherical

AbstractOur knowledge of bacterial nucleoids originates mostly from studies of rod- or crescent-shaped bacteria. Here, we reveal that Deinococcus radiodurans, a relatively large, spherical bacterium, possessing a multipartite genome, and well-known for its radioresistance, constitutes a valuable system for the study of nucleoids in cocci. Using advanced microscopy, we show that as D. radiodurans progresses through its cell cycle, it undergoes coordinated morphological changes at both the cellular and nucleoid level. D. radiodurans nucleoids were found to be highly condensed, but also surprisingly dynamic, adopting multiple distinct configurations and presenting a novel chromosomal arrangement in which oriC loci are radially distributed around clustered ter sites maintained at the centre of cells. Single-molecule and ensemble studies of the abundant histone-like HU protein suggest that its loose binding to DNA may contribute to this remarkable plasticity. These findings clearly demonstrate that nucleoid organization is complex and tightly coupled to cell cycle progression.

scholarly journals TheTrypanosoma bruceiCyclin, CYC2, Is Required for Cell Cycle Progression through G1Phase and for Maintenance of Procyclic Form Cell Morphology

2004 ◽  
Vol 279 (23) ◽  
pp. 24757-24764 ◽  
Author(s):  
Tansy C. Hammarton ◽  
Markus Engstler ◽  
Jeremy C. Mottram
Keyword(s):  
Cell Cycle ◽  
Cell Morphology ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Procyclic Form

scholarly journals DNA Ligase I Deficiency Leads to Replication-Dependent DNA Damage and Impacts Cell Morphology without Blocking Cell Cycle Progression

2009 ◽  
Vol 29 (8) ◽  
pp. 2032-2041 ◽  
Author(s):  
Samuela Soza ◽  
Valentina Leva ◽  
Riccardo Vago ◽  
Giovanni Ferrari ◽  
Giuliano Mazzini ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Morphology ◽  
Cell Cycle Progression ◽  
S Phase ◽  
Dna Ligase ◽  
Cycle Progression ◽  
Genetic Syndrome ◽  
Γh2ax Foci ◽  
Dna Ligase I

ABSTRACT 46BR.1G1 cells derive from a patient with a genetic syndrome characterized by drastically reduced replicative DNA ligase I (LigI) activity and delayed joining of Okazaki fragments. Here we show that the replication defect in 46BR.1G1 cells results in the accumulation of both single-stranded and double-stranded DNA breaks. This is accompanied by phosphorylation of the H2AX histone variant and the formation of γH2AX foci that mark damaged DNA. Single-cell analysis demonstrates that the number of γH2AX foci in LigI-defective cells fluctuates during the cell cycle: they form in S phase, persist in mitosis, and eventually diminish in G1 phase. Notably, replication-dependent DNA damage in 46BR.1G1 cells only moderately delays cell cycle progression and does not activate the S-phase-specific ATR/Chk1 checkpoint pathway that also monitors the execution of mitosis. In contrast, the ATM/Chk2 pathway is activated. The phenotype of 46BR.1G1 cells is efficiently corrected by the wild-type LigI but is worsened by a LigI mutant that mimics the hyperphosphorylated enzyme in M phase. Notably, the expression of the phosphomimetic mutant drastically affects cell morphology and the organization of the cytoskeleton, unveiling an unexpected link between endogenous DNA damage and the structural organization of the cell.

E2F4 plays a much more important role than E2F1 in the promotion of cell cycle progression of human intestinal cells

2001 ◽  
Vol 120 (5) ◽  
pp. A501-A502
Author(s):  
C DESCHENES ◽  
A VEZINA ◽  
N RIVARD
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Intestinal Cells ◽  
Cycle Progression ◽  
Human Intestinal Cells

The inner plasma membrane protein Plac8 regulates cell cycle progression in pancreatic ductal adenocarcinoma (PDAC)

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
M Buchholz ◽  
B Kaistha ◽  
H Lorenz ◽  
H Schmidt ◽  
N Weber-Lassalle ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Plasma Membrane ◽  
Membrane Protein ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Cycle Progression ◽  
Ductal Adenocarcinoma ◽  
Plasma Membrane Protein ◽  
Cycle Progression

MicroRNA - 497~195 cluster suppresses cell cycle progression by targeting CCND3/CDK4 in acute lymphoblastic leukemia

2020 ◽  
Author(s):  
E Boldrin ◽  
E Gaffo ◽  
JM Boer ◽  
R Claus ◽  
C Plass ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Lymphoblastic Leukemia ◽  
Cell Cycle Progression ◽  
Lymphoblastic Leukemia ◽  
Cycle Progression

Modulation of cell cycle progression by combined rapamycin-octreotide treatment in pituitary tumor cells

2007 ◽  
Vol 115 (08) ◽  
Author(s):  
V Cerovac ◽  
M Reimann ◽  
GK Stalla ◽  
M Theodoropoulou
Keyword(s):  
Cell Cycle ◽  
Tumor Cells ◽  
Pituitary Tumor ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Octreotide Treatment

Cell Cycle Progression

2020 ◽  
Author(s):  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cycle Progression

1955-P: GLP-1R Activation Attenuates Prostate Cancer Growth via Inhibiting Cell Cycle Progression

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1955-P
Author(s):  
TORU SHIGEOKA ◽  
TAKASHI NOMIYAMA ◽  
TAKAKO KAWANAMI ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cancer Growth ◽  
Cycle Progression
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