Non‐polar metabolites of green beans ( Phaseolus vulgaris L.) potentiate the antidiabetic activity of mesenchymal stem cells in streptozotocin‐induced diabetes in rats

Author(s):  
Shahira M. Ezzat ◽  
Mohamed F. Abdel Rahman ◽  
Maha M. Salama ◽  
Engy A. Mahrous ◽  
Amany El Bariary
Food Control ◽  
2021 ◽  
Vol 124 ◽  
pp. 107936
Author(s):  
Zhi Qu ◽  
Zhongwei Tang ◽  
Fang Liu ◽  
Shyam S. Sablani ◽  
Carolyn F. Ross ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Guo Qing-Song ◽  
Zhu Ming-Yan ◽  
Wang Lei ◽  
Fan Xiang-Jun ◽  
Lu Yu-Hua ◽  
...  

Aims. The goal of cell transcription for treatment of diabetes is to generate surrogateβ-cells from an appropriate cell line. However, the induced replacement cells have showed less physiological function in producing insulin compared with normalβ-cells.Methods. Here, we report a procedure for induction of insulin-producing cells (IPCs) from bone marrow murine mesenchymal stem cells (BM-mMSCs). These BM-mMSCs have the potential to differentiate into insulin-producing cells when a combination of PDX-1 (pancreatic and duodenal homeobox-1), NeuroD1 (neurogenic differentiation-1), and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homolog A) genes are transfected into them and expressed in these cells.Results. Insulin biosynthesis and secretion were induced in mMSCs into which these three genes have been transfected and expressed. The amount of induced insulin in the mMSCs which have been transfected with the three genes together is significantly higher than in those mMSCs that were only transfected with one or two of these three genes. Transplantation of the transfected cells into mice with streptozotocin-induced diabetes results in insulin expression and the reversal of the glucose challenge.Conclusions. These findings suggest major implications for cell replacement strategies in generation of surrogateβ-cells for the treatment of diabetes.


1995 ◽  
Vol 43 (9) ◽  
pp. 2480-2486 ◽  
Author(s):  
Trinette Stolle-Smits ◽  
Jan G. Beekhuizen ◽  
Cees van Dijk ◽  
Alfons G. J. Voragen ◽  
Kees Recourt

2018 ◽  
Vol 231 ◽  
pp. 15-21 ◽  
Author(s):  
Antonio Minnocci ◽  
Alessandra Francini ◽  
Stefania Romeo ◽  
Alfredo Daniele Sgrignuoli ◽  
Giovanni Povero ◽  
...  

1997 ◽  
Vol 30 (10) ◽  
pp. 787-791 ◽  
Author(s):  
Carlos De La Cruz-Garcı́a ◽  
Marı́a José González-Castro ◽  
Marı́a José Oruña-Concha ◽  
Julia López-Hernández ◽  
Jesús Ángel Simal-Lozano ◽  
...  

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