Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis

2016 ◽  
Vol 31 (5) ◽  
pp. 936-944 ◽  
Author(s):  
Stefano Ballestri ◽  
Stefano Zona ◽  
Giovanni Targher ◽  
Dante Romagnoli ◽  
Enrica Baldelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver ◽  
Incident Type ◽  
Increased Risk ◽  
Incident Type 2 Diabetes

scholarly journals Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

Diabetes Care ◽  
2018 ◽  
Vol 41 (2) ◽  
pp. 372-382 ◽  
Author(s):  
Alessandro Mantovani ◽  
Christopher D. Byrne ◽  
Enzo Bonora ◽  
Giovanni Targher
Keyword(s):  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Circulating Saturated Fatty Acids and Incident Type 2 Diabetes: A Systematic Review and Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 998 ◽  
Author(s):  
Lihua Huang ◽  
Jie-sheng Lin ◽  
Izzuddin M Aris ◽  
Guiyou Yang ◽  
Wei-Qing Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Protective Effect ◽  
Meta Analysis ◽  
Saturated Fatty Acids ◽  
Incident Type ◽  
Increased Risk ◽  
Incident Type 2 Diabetes

The effect of saturated fatty acids (SFAs) on incident type 2 diabetes (T2D) is controversial and few have systematically appraised the evidence. We conducted a comprehensive search of prospective studies examining these relationships that were published in PubMed, Web of Science, or EMBASE from 21 February 1989 to 21 February 2019. A total of 19 studies were included for systematic review and 10 for meta-analysis. We estimated the summarized relative risk (RR) and 95% confidence interval (95% CI) using a random (if I2 > 50%) or a fixed effects model (if I2 ≤ 50%). Although the included studies reported inconclusive results, the majority supported a protective effect of odd-chain and an adverse impact of even-chain SFAs. Meta-analysis showed that the per standard deviation (SD) increase in odd-chain SFAs was associated with a reduced risk of incident T2D (C15:0: 0.86, 0.76–0.98; C17:0: 0.76, 0.59–0.97), while a per SD increase in one even-chain SFA was associated with an increased risk of incident T2D (C14:0: 1.13, 1.09–1.18). No associations were found between other SFAs and incident T2D. In conclusion, our findings suggest an overall protective effect of odd-chain SFAs and the inconclusive impact of even- and very-long-chain SFAs on incident T2D.

scholarly journals Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies

2017 ◽  
Vol 189 (20) ◽  
pp. E711-E720 ◽  
Author(s):  
Christine S. Tsilas ◽  
Russell J. de Souza ◽  
Sonia Blanco Mejia ◽  
Arash Mirrahimi ◽  
Adrian I. Cozma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Total Sugars ◽  
Incident Type ◽  
Prospective Cohort Studies ◽  
Incident Type 2 Diabetes
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