Dietary vitamin D intake, cardiovascular disease and cardiometabolic risk factors: a sex‐based analysis from the ATTICA cohort study

2020 ◽  
Vol 33 (5) ◽  
pp. 708-717
Author(s):  
M. Kouvari ◽  
D. B. Panagiotakos ◽  
C. Chrysohoou ◽  
M. Yannakoulia ◽  
E. N. Georgousopoulou ◽  
...  
Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S65
Author(s):  
G. Snellman⁎ ◽  
L. Byberg ◽  
E. Warensjö Lemming ◽  
H. Melhus ◽  
R. Gedeborg ◽  
...  

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S136-S137 ◽  
Author(s):  
G. Snellman⁎ ◽  
L. Byberg ◽  
E. Warensjö Lemming ◽  
H. Melhus ◽  
R. Gedeborg ◽  
...  

2014 ◽  
Vol 12 (3) ◽  
pp. 171-177 ◽  
Author(s):  
Carla Moreira ◽  
Pedro Moreira ◽  
Sandra Abreu ◽  
Paula C. Santos ◽  
Isabel Moreira-Silva ◽  
...  

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Kouvari ◽  
D.B Panagiotakos ◽  
C Chrysohoou ◽  
M Yannakoulia ◽  
E.N Georgousopoulou ◽  
...  

Abstract Background/Introduction Increasing vitamin D intake through food supplements or fortification is far from revealing strong contribution to cardiac health. On the other side, the separate evaluation of dietary vitamin D intake with cardiac health is limited. Purpose The aim of the present work was to evaluate the association between dietary vitamin D intake and 10-year first fatal/non fatal CVD, conventional CVD risk factors and surrogate markers related with inflammation, coagulation, insulin resistance, liver and renal function. Methods ATTICA prospective study was conducted during 2001–2012 and included n=1,514 men and n=1,528 women (aged >18 years old) from the greater Athens area, Greece. Dietary assessment was based on a validated semi-quantitative food frequency questionnaire. Daily intake of vitamin D was calculated through standardized food database. Follow-up assessment of CVD (2011–2012) was achieved in n=2,020 participants (n=317 cases). Results Ranking from 1st to 3rd vitamin D tertile, CVD event was for men 24%, 17% and 12% (p=0.002) and for women 14%, 10% and 11% (p=0.59), respectively. Multiadjusted analysis revealed inverse associations between vitamin D and CVD in total sample [Hazard Ratio (HR)=0.76 95% Confidence Interval (95% CI) (0.60, 0.97)] and in men [HR=0.66 95% CI (0.49, 0.89)], lost after adjusting for inflammation/coagulation markers; for women no significant trends against hard CVD endpoints were observed. Regarding 10-year onset of conventional risk factors, inverse associations of vitamin D with hypertension in men [HR=0.62 95% CI (0.39, 0.99)] and transition to metabolically unhealthy status in women [HR=0.69 95% CI (0.51, 0.93)] were observed. Multiadjusted analyses revealed significant inverse associations for C-reactive protein, interleukin-6 and fibrinogen in both sexes while only in women for insulin resistance. Conclusions Contradicting the neutral/modest associations in vitamin D supplementation trials, the present work revealed that increased food-generated vitamin D may protect against hard and intermediate CVD endpoints implying the existence of different paths between sexes. Funding Acknowledgement Type of funding source: Other. Main funding source(s): This work was supported by a research grant from Hellenic Atherosclerosis Society. The ATTICA study is supported by research grants from the Hellenic Cardiology Society [HCS2002] and the Hellenic Atherosclerosis Society [HAS2003].


Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Marta P Suarez-Rivera ◽  
Wilmarie Bruckman ◽  
Ana García ◽  
Melvin Bonilla-Felix

Purpose: Overweight, obesity, hypertension (HTN), insulin resistance, and dyslipidemia have been recognized as cardiometabolic risk factors in adults. Early markers of cardiovascular disease in children are lacking. Low vitamin D (VITD) levels are associated with higher blood pressure, obesity and insulin resistance. We explored the association between traditional cardiometabolic risk factors and VITD levels with HTN status in adolescents. DESIGN METHODS: Cross-sectional pilot study in students from grades 9th - 12th in Puerto Rico. Fasting blood samples to estimate serum lipids, fasting glucose and vitamin D25OH levels were obtained, with anthropometric and blood pressure measurements. Variables described as mean [standard deviation (sd)] or frequencies and percentages as appropriate. Bivariate analysis using chi-square test; statistical significance was set at p<0.05. Results: 78 adolescents, mean age: 16 years were studied. Mean BMI: 23.8 (range 17-39); 19.2% (15/78) were overweight and 16.7% (13/78) were obese. Pre-HTN observed in 7.7% (6/78), with 1 HTN. Hypercholesterolemia (≥170 mg/dl): 16.9% 13/77), low HDL levels (≤ 40 mg/dl): 67.5% 23/77), and hypertriglyceridemia (≥ 110 mg/dl): 15.6% (12/77). VITD levels were low (< 30ng/dL) in 31% 24/77. Obese subjects were more likely to have insufficient VITD levels when compared with the non-obese, (61.5% vs 25%; p=0.02).At least 1 cardiometabolic risk factor was found in 69% (54/78); 33% (26/78) had 2 or more. Conclusion: Obesity is associated with low VITD levels and preHTN. Cardiometabolic risk factors are highly prevalent in our population. Interventions to prevent cardiovascular disease in Puerto Rican adolescents are required.


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