Does a combination of platelet‐rich plasma and decalcified freeze‐dried bone allograft offer advantages over decalcified freeze‐dried bone allograft alone when using pocket depth and clinical attachment level as markers for periodontal healing? A literature review

2019 ◽  
Vol 10 (2) ◽  
pp. e12397
Author(s):  
Jashan Jethwa ◽  
Robert S. Ireland ◽  
David Chan
Keyword(s):  
Literature Review ◽  
Platelet Rich Plasma ◽  
Bone Allograft ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Freeze Dried ◽  
Periodontal Healing ◽  
Attachment Level

scholarly journals Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial

2016 ◽  
Vol 17 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Mahmoud Abu-Ta'a
Keyword(s):  
Clinical Trial ◽  
Tissue Regeneration ◽  
Bone Allograft ◽  
Guided Tissue Regeneration ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Freeze Dried ◽  
Attachment Level ◽  
Preservation Technique ◽  
Postoperative Discomfort

ABSTRACT Aim This randomized clinical trial compares the usefulness of adjunctive antibiotics, while strict asepsis was followed during periodontal surgery involving guided tissue regeneration. Materials and methods Two groups of 20 consecutive patients each with advanced periodontal disease were randomly assigned to treatment. They displayed one angular defect each with an intrabony component ≥3 mm, probing pocket depth and probing attachment level (PAL) ≥7 mm. Test group included 13 males, mean age 60 years, treated with enamel matrix derivative (EMD) and demineralized freeze-dried bone allograft with modified papilla preservation technique, received oral amoxicillin 1 gm, 1 hour preoperatively and 2 gm for 2 days postoperatively. Control group included 10 males, mean age 57 years, treated with EMD and demineralized freeze-dried bone allograft with modified papilla preservation technique, received no antibiotics. Outcome measures were clinical attachment level (CAL) gain, residual periodontal pocket depth (res. PD), gingival recession (GR), bleeding on probing (BOP), adverse events and postoperative complications. Patients were followed up to 12 months after periodontal surgery involving guided tissue regeneration. Results There were no significant differences between both groups for CAL gain, res. PD, GR, BOP nor other clinical parameters, though patients’ subjective perception of postoperative discomfort was significantly smaller in the group receiving antibiotics. Conclusion Antibiotics do not provide significant advantages concerning clinical periodontal parameters nor concerning postoperative infections in case of proper asepsis. It does, on the contrary, reduce postoperative discomfort. Clinical significance Regarding the results of this study, adjunctive systemic antibiotics in combination with guided tissue regeneration may be useful in reducing postoperative discomfort but may not be helpful for improving periodontal regeneration outcomes. How to cite this article Abu-Ta'a M. Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial. J Contemp Dent Pract 2016;17(1):3-6.

scholarly journals Differences in results of infrabony pocket treatment with addition of platelet rich fibrin and platelet rich plasma gel in DFDBA bone graft

2019 ◽  
Vol 1 (1) ◽  
pp. 29
Author(s):  
Netta Anggraini ◽  
Sri Pramestri Lastianny ◽  
Al Sri Koes Soesilowati
Keyword(s):  
Bone Graft ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Bone Allograft ◽  
Graft Material ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Freeze Dried ◽  
Bone Height ◽  
Prp Gel

Treatment of infrabony pocket makes use of bone graft material demineralized freeze dried bone allograft (DFDBA) from different individuals which has undergone demineralization process and it is osteoinductive. Enhancement of growth factor was done by adding platelet rich fibrin (PRF) and platelet rich plasma (PRP). PRP is activated with an addition of calcium chloride CaCl2) to form gel. The method used to apply the bone grafting material is open flap debridement OFD). This research aimed to reveal the differences in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA. The sample was taken from 20 infrabony pocket points divided into 2 groups, 10 infrabony pocket were treated with OFD+DFDBA+PRF and the other were treated with OFD+DFDBA+PRP gel. Pocket depth (PD) was measured on the baseline and the first and third month after treatment. Alveolar bone height was measured using cone beam computed tomography (CBCT) radiograph on the baseline to the third month after treatment. The results of this research showed that there was difference in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA which could be observed from a reduction in PD from the baseline, month 1 and month 3 as well as reduction in alveolar bone height from the baseline to month 3. This research concluded that infrabony pocket treatment PRF application yields better results than PRP gel application in terms of PD and alveolar bone height reduction.

What is the Efficacy of Beta-tricalcium Phosphate as Graft Material in Periodontal Infra-bony Defects? Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Reham Al-Jasser ◽  
Abdulelah AlSubaie ◽  
Fayez Alshehri
Keyword(s):  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Controlled Study ◽  
Bony Defect ◽  
Graft Material ◽  
Inclusion Criteria ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Attachment Level ◽  
Depth Reduction

Abstract Background: β-TCP is a synthetic grafting material (alloplasts)that can be used as allografts and xenografts in peridontal periodontal infra-bony defect. However, it is important to compare this material outcomes in such treatments when comparted to others Therefore, the aim of this review is to evaluate the effectiveness of β-TCP in the regeneration of periodontal infra-bony defect. Methods: Three electronic databases (Cochrane, Pubmed, Embase) were searched up to March 2020. The inclusion criteria consist of regeneration of periodontal infra-bony defect via implementation of β-TCP in combination with other bone graft materials. Outcomes consisted of pocket depth reduction, clinical attachment level gain and bone fill. Results: Five studies were included according to inclusion criteria. β-TCP found to be superior than debridement alone while it shown comparable result to other bone grafts materials in term of pocket depth reduction, clinical attachment level gain and bone fill. the outcomes of the regenerative procedures of periodontal infra-bony defect with the use of β-TCP in combination with other growth factors seems to be superior than alone. Conclusion: β-TCP seems to be a promising material to be used in periodontal infra-bony defect regeneration. However, randomized clinical trials with larger sample size and more controlled study design are needed to support the findings.

scholarly journals A retrospective clinical, radiographic and microbiological study of periodontal conditions of teeth with and without crowns

2007 ◽  
Vol 21 (4) ◽  
pp. 348-354 ◽  
Author(s):  
Marcio Dias Giollo ◽  
Patrícia Moura Valle ◽  
Sabrina Carvalho Gomes ◽  
Cassiano Kuchenbecker Rösing
Keyword(s):  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Mean Values ◽  
Probing Pocket Depth ◽  
Periodontal Breakdown ◽  
And Control ◽  
Attachment Level ◽  
Digital Caliper ◽  
Bana Test

The aim of this study was to evaluate retrospectively the periodontal conditions of teeth with fixed crowns that had been in place from 3 to 5 years before the study was conducted. Forty individuals were recalled for a follow-up visit. Full-mouth clinical examinations were carried out and Visible Plaque Index (VPI), Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD), and clinical attachment level (CAL) were assessed in 6 sites per tooth. Parallel radiographs were also taken and blindly analyzed by a digital caliper (distance between the apex and the bone crest). BANA tests were performed. A contra-lateral sound tooth was considered the control. Mean values were obtained and Wilcoxon and paired sample t tests were used to compare the test and control sites. Crowns had a mean VPI value of 30.42% as compared to 49.17% for sound teeth. The GBI was 33.33% and 26.25% for test and control teeth respectively. Assessment of PPD revealed values of 2.30 and 2.14 mm, and assessment of CAL revealed averages of 2.02 and 1.89 mm for test and control teeth respectively. The mean values for radiographic distances were 12.73 and 13.67 mm, and for the BANA test, 67.50 and 50.00 for sound and crowned teeth, respectively. Statistically significant differences were observed for all parameters except for CAL and for the BANA test. It may be concluded that, with the methods used in the present study, crowns may be associated with more signs of inflammation, however not with periodontal breakdown.

The Use of Platelet-Rich Plasma Combined With Demineralized Freeze-Dried Bone Allograft in the Treatment of Periodontal Endosseous Defects

2010 ◽  
Vol 141 (8) ◽  
pp. 967-978 ◽  
Author(s):  
Nikolaos Markou ◽  
Eudoxie Pepelassi ◽  
Sotirios Kotsovilis ◽  
Ioannis Vrotsos ◽  
Helen Vavouraki ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Bone Allograft ◽  
Freeze Dried

Treatment of Periodontal Endosseous Defects With Platelet-Rich Plasma Alone or in Combination With Demineralized Freeze-Dried Bone Allograft: A Comparative Clinical Trial

2009 ◽  
Vol 80 (12) ◽  
pp. 1911-1919 ◽  
Author(s):  
Nikolaos Markou ◽  
Eudoxie Pepelassi ◽  
Helen Vavouraki ◽  
Harry C. Stamatakis ◽  
Georgios Nikolopoulos ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Platelet Rich Plasma ◽  
Bone Allograft ◽  
Comparative Clinical Trial ◽  
Freeze Dried

scholarly journals Probing Pocket Depth and Clinical Attachment Level between Non-Surgical and Surgical Periodontal Therapy in Chronic Periodontitis Patients: A Randomised Controlled Clinical Trial

2018 ◽  
Vol 2 (2) ◽  
pp. 40-44
Author(s):  
Harish Kumar Shah ◽  
Shivalal Sharma ◽  
Khushboo Goel ◽  
Sajeev Shrestha ◽  
Surya Raj Niraula
Keyword(s):  
Clinical Trial ◽  
Surgical Therapy ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Probing Pocket Depth ◽  
The Mean ◽  
The Difference ◽  
Attachment Level

Background: : Chronic periodontitis is one of the most common form of periodontal diseases which either require non-surgical periodontal therapy or open flap debridement-surgical therapy or both. To date, it is unclear as of how much changes occur after NSPT or OFD and which therapy provides the best outcome in chronic periodontitis having probing pocket depth ≥ 5-7 mm. Aim: The aim of this randomized controlled clinical trial was to evaluate the Probing Pocket Depth and Clinical Attachment Level between NSPT and OFD in chronic periodontitis patients. Materials and Methods: A total of 52 healthy patients with PPD ≥ 5-7 mm were included in the present study. Half of the patients assigned for the NSPT and half in the OFD group. The PPD and CAL were measured at baseline, three and six months. Independent sample t-test was used to compare the change in mean PPD and CAL between NSPT and OFD group at three and six months, respectively. Results: The difference in the mean decrease of PPD between NSPT and OFD group at three and six months were 0.15 mm (P<0.05) and 0.19 mm (P<0.05), respectively. The difference in the mean gain of CAL between NSPT and OFD group at three and six months were 0.03 mm (p>0.05) and 0.12 mm (P<0.05), respectively. Conclusion: Substantial improvement in periodontal status occurred with both the therapies, however, significantly higher decrease in PPD and gain in CAL were seen with surgical therapy.

Bone Formation in the Maxillary Sinus by Using Platelet-rich Plasma: An Experimental Study in Sheep

2005 ◽  
Vol 31 (1) ◽  
pp. 2-17 ◽  
Author(s):  
Edgar Grageda ◽  
Jaime L. Lozada ◽  
Phillip J. Boyne ◽  
Nicholas Caplanis ◽  
Paul J. McMillan
Keyword(s):  
Platelet Count ◽  
Bone Regeneration ◽  
Maxillary Sinus ◽  
Platelet Rich Plasma ◽  
Test Group ◽  
Bone Allograft ◽  
Autogenous Bone ◽  
Control Group ◽  
Freeze Dried ◽  
Log Ratio

Abstract Recently, platelet-rich plasma (PRP) has been proven to be an effective regeneration adjunct when combined with autogenous bone in the reconstruction of mandibular defects. However, little is known about the effect of PRP when combined with a bone allograft in the maxillary sinus. The purpose of this study was to quantitatively evaluate the ability of PRP to enhance bone regeneration in the maxillary sinus of sheep when combined with demineralized freeze-dried bone allograft (DFDBA) and cortical cancellous freeze-dried bone allograft (CCFDBA). Ten sheep were selected for bilateral sinus augmentation DFDBA + CCFDBA + PRP (test) and DFDBA + CCFDBA (control). Five were sacrificed at 3 months and the other 5 at 6 months. Hematology tests were performed for platelet count, and histology slides were obtained for histomorphometric analysis taking 2 measures of interest: total area (square millimeters) and percentage of bone fill. Student t tests showed no significant difference between test and control groups for total area (P &gt; .25) and percentage of bone fill (P &gt; .80) at either 3 or 6 months. The control group showed no statistical difference for total area (P &lt; .095) and percentage of bone fill (P &lt; .60) between 3- and 6-month healing times. The test group, however, showed a significant increase in total area (P &lt; .025) but not in percentage of bone fill (P &lt; .40) for the 2 healing periods. When the treatments were compared for interactions within the animal model, no clear tendency was evident for the test group to perform in relation to the control group regarding total area (r = .766, P &lt; .01). A moderate tendency existed between the percentages of bone filled (r = .824, P &lt; .005). Platelet-rich plasma showed higher platelet count than did the whole blood (2 to 5 times). However, no correlation was found between the log ratio and the bone measures. Within the limitations of this study, PRP failed to enhance or accelerate bone regeneration in the maxillary sinus of sheep when combined with bone allograft.

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