Distribution of Androgen and Oestrogen Receptors-α in the Seminal Vesicle-Related Spinal Neurones in Male Rats

2013 ◽  
Vol 25 (6) ◽  
pp. 547-559 ◽  
Author(s):  
X. Q. Sun ◽  
C. Xu ◽  
P. Leclerc ◽  
F. Giuliano ◽  
G. Benoît ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Male Rats ◽  
Oestrogen Receptors ◽  
Spinal Neurones

The Effect of Androgen Depletion and Replacement on the Epithelium of the Seminal Vesicle of the Aging Rat

1975 ◽  
Vol 33 ◽  
pp. 590-591
Author(s):  
Venita F. Allison
Keyword(s):  
Cell Proliferation ◽  
Seminal Vesicle ◽  
Male Rats ◽  
Target Cells ◽  
Cell Regeneration ◽  
Secretory Function ◽  
Electron Microscopic ◽  
Aging Rat ◽  
Microscopic Studies ◽  
Androgen Depletion

In 1930, Moore, Hughes and Gallager reported that after castration seminal vesicle epithelial cell atrophy occurred and that cell regeneration could be achieved with daily injections of testis extract. Electron microscopic studies have confirmed those observations and have shown that testosterone injections restore the epithelium of the seminal vesicle in adult castrated male rats. Studies concerned with the metabolism of androgens point out that dihydrotestosterone stimulates cell proliferation and that other metabolites of testosterone probably influence secretory function in certain target cells.Although the influence of androgens on adult seminal vesicle epithelial cytology is well documented, little is known of the effect of androgen depletion and replacement on those cells in aging animals. The present study is concerned with the effect of castration and testosterone injection on the epithelium of the seminal vesicle of aging rats.

EFFECTS OF TESTOSTERONE AND NANDROLONE AND SOME OF THEIR ESTERS ON THE PSEUDOCHOLINESTERASE ACTIVITY IN THE LIVER AND SERUM AND ON THE SEMINAL VESICLE AND LEVATOR ANI MUSCLE OF THE RAT

1970 ◽  
Vol 64 (3) ◽  
pp. 531-540 ◽  
Author(s):  
R. S. Leeuwin ◽  
E. Th. Groenewoud
Keyword(s):  
Enzyme Activity ◽  
Seminal Vesicle ◽  
Testosterone Propionate ◽  
Levator Ani ◽  
Daily Administration ◽  
Male Rats ◽  
Levator Ani Muscle ◽  
Prolonged Administration ◽  
Potent Effect ◽  
T Testosterone

ABSTRACT Testosterone (T), testosterone-propionate (TP), testosterone-phenyl-propionate (TPP), nandrolone (N) (19-nor-testosterone) and nandrolone-phenyl-propionate (NPP) were compared for their effects on the pseudocholinesterase activities in the liver and serum of castrated male rats. In addition changes in the weight of the seminal vesicle and the levator ani muscle were studied. After daily administration of 1 mg of the hormones for ten days, T and TPP showed a more marked depression of the pseudocholinesterase activity and seminal vesicle than the corresponding nor-derivatives. TP and TPP have approximately similar effects, exceeding those of T. On the levator ani N and NPP were more effective than T and TPP. At identical total doses, administration of all hormones with intervals of more than one day, produced less depression of the pseudocholinesterase activity and less seminal vesicle growth than daily administration. The effects on the levator ani were less influenced by varying intervals. At an interval of four days TPP still had a potent effect on the enzyme activity and the seminal vesicle, whereas T was almost without effect. Prolonged administration showed that the effects on the enzyme activity and the seminal vesicle of N and NPP could not reach the maximum effects of T and TPP respectively.

DISTRIBUTION OF ANDROGEN RECEPTORS IN SPINAL NEURONES INNERVATING THE SEMINAL VESICLE IN MALE RAT

2006 ◽  
Vol 5 (2) ◽  
pp. 63
Author(s):  
Q.S. Xue ◽  
C. Xu ◽  
E.D. Yaici ◽  
F. Giuliano ◽  
L. Cayzergues ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Androgen Receptors ◽  
Male Rat ◽  
Spinal Neurones

THE COMPARATIVE ACTIONS OF TESTOSTERONE PROPIONATE AND 5α-ANDROSTAN17β-OL-3-ONE PROPIONATE ON THE REPRODUCTIVE BEHAVIOUR, PHYSIOLOGY AND MORPHOLOGY OF MALE RATS

1971 ◽  
Vol 51 (2) ◽  
pp. 241-NP ◽  
Author(s):  
H. H. FEDER
Keyword(s):  
Body Weight ◽  
Seminal Vesicle ◽  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Reproductive Behaviour ◽  
Male Rats ◽  
Male Sexual Behaviour ◽  
Testicular Weight ◽  
Seminal Vesicle Weight ◽  
Experienced Adult

SUMMARY 5α-Androstan-17β-ol-3-one in its free or in its propionate form was injected systemically (125 μg/day/rat) into sexually experienced, adult, castrated, male rats. These compounds were ineffective in activating masculine behaviour patterns, despite having measurable effects on body weight, seminal vesicle weight and penile morphology. The propionate form also had strong anti-gonadotrophic properties, since when it was injected for 6 days into intact, immature, male rats it significantly reduced testicular weight. In contrast, testosterone propionate (125 μg/day/rat) restored male sexual behaviour to the levels found before castration when injected systemically. Testosterone propionate also affected body weight, seminal vesicle weight, penile morphology and the testicular weight of immature males. These effects may have been due in part to conversion of testosterone to 5α-androstan-17β-ol-3-one, but this metabolic step does not seem to be obligatory for activation of male sexual behaviour in rats.

Sex-steroid receptors in the diethylnitrosamine model of hepatocarcinogenesis: modifications by gonadal ablation and steroid replacement therapy

1989 ◽  
Vol 3 (3) ◽  
pp. 229-237 ◽  
Author(s):  
S. Tejura ◽  
G. R. Rodgers ◽  
M. H. Dunion ◽  
M. A. Parsons ◽  
J. C. E. Underwood ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Androgen Receptors ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Female Rats ◽  
Male Rats ◽  
Ovariectomized Rats ◽  
Sex Steroid ◽  
Oestrogen Receptors ◽  
Liver Tumours

ABSTRACT The results of this study confirm our previous report of increased androgen receptor expression in livers of female SUAH Wistar rats during development of liver tumours induced by diethylnitrosamine (DENA). In adult female rats not treated with DENA, removal of the ovary increased liver androgen receptor levels but testosterone did not further enhance the androgen receptor status of ovariectomized rats. In normal adult males the testis and/or testosterone maintained high levels of androgen receptors but oestrogen reduced them in castrated rats. Oestrogen receptor levels were not significantly changed in either males or females by gonadectomy. Treatment of female rats with DENA for 10 and 16 weeks increased liver androgen receptors but oestrogen receptors were only reduced by 16 weeks of DENA treatment, whether the rats were intact or ovariectomized. Concentrations of liver androgen receptors were increased in intact and castrated male rats by 10 and 16 weeks of DENA treatment, an increase not seen in the previous experiments. Oestrogen appeared to inhibit both the increases in liver androgen receptor expression and liver tumour development in rats treated with the weakly carcinogenic dose of 10 weeks of DENA. However, the full carcinogenic dose of 16 weeks of DENA increased liver androgen receptors and decreased oestrogen receptors in female rats regardless of sex-steroid status. Development of malignant hepatocellular carcinoma (HCC) was associated with both an increase in liver androgen receptors and a decrease in oestrogen receptors. Maintenance of relatively high levels of liver oestrogen receptors appeared to protect the liver against development of HCC.

Effect of cyproterone acetate in comparison to flutamide and megestrol acetate on the ventral prostate, seminal vesicle, and adrenal glands of adult male rats

The Prostate ◽  
1987 ◽  
Vol 11 (4) ◽  
pp. 361-375 ◽  
Author(s):  
M. Fathy El Etreby ◽  
Ursula-F. Habenicht ◽  
Thomas Louton ◽  
Yukishige Nishino ◽  
Helmut G. Schröder
Keyword(s):  
Seminal Vesicle ◽  
Adult Male ◽  
Cyproterone Acetate ◽  
Adrenal Glands ◽  
Megestrol Acetate ◽  
Male Rats ◽  
Ventral Prostate

INFLUENCE OF VARIOUS STEROIDS ON TESTES AND ACCESSORY SEX ORGANS IN THE RAT

1965 ◽  
Vol 49 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Fred A. Kind ◽  
M. Maqueo ◽  
Ralph I. Dorfman
Keyword(s):  
Seminal Vesicle ◽  
Treatment Period ◽  
Post Treatment ◽  
Testicular Atrophy ◽  
Male Rats ◽  
Ventral Prostate ◽  
Testis Weight ◽  
Intact Male ◽  
Seminal Vesicle Weight ◽  
Testicular Histology

ABSTRACT Various neutral steroids were studied in intact male rats for their ability to influence testicular function, particularly spermatogenesis. The compounds were injected once daily for 21 days, starting at 21 days of age. One day after the last injection, testicular histology and testis, ventral prostate, and seminal vesicle weights were determined. In some experiments, after the standard 21 day treatment period, testicular histology and function were evaluated after 30 and 60 day post-treatment recovery periods. 2α-Hydroxymethyl-17β-hydroxy-5α-androstan-3-one, 2-hydroxy-5α-androst-2-en-17β-ol, 2,17α-dimethyl-5α-androst-2-en-17β-ol and 2-formyl5α-androst-2-en-17β-ol caused decreases in testicular, ventral prostate and seminal vesicle weight and produced arrest of spermatogenesis. These effects were reversible and testis weight and histology, as well as fertility, were restored in the post-treatment period. 19-Norprogesterone, which did not produce convincing testicular atrophy, did cause significant decreases in ventral prostate and seminal vesicle weight. Chlormadinone showed a similar picture, although direct antagonistic testicular effects were also seen. The lowered ventral prostate and seminal vesicle weights produced by these compounds may be an expression of their antiandrogenic activity.

A COMPARISON OF SEMINAL VESICLE, KIDNEY AND ADRENAL RESPONSES IN THE RAT FOLLOWING THE ADMINISTRATION OF ANDROGEN

1960 ◽  
Vol XXXIV (III) ◽  
pp. 344-352 ◽  
Author(s):  
Jerome A. Grunt ◽  
Joseph E. Walker
Keyword(s):  
Seminal Vesicle ◽  
Histological Examination ◽  
Testosterone Propionate ◽  
Seminal Vesicles ◽  
Sesame Oil ◽  
Male Rats ◽  
Subcutaneous Injections ◽  
Sexual Organ ◽  
Seminal Vesicle Weight

ABSTRACT The responses of several seminal vesicle in vivo microscopic characteristics, seminal vesicle contractions, seminal vesicle, kidney and adrenal weights and seminal vesicle histology have been compared following the administration of testosterone propionate (T. P.) and norethandrolone (19-NT) to castrated male rats. Fourteen days after castration 35 male Osborne-Mendel rats were divided into 5 groups each containing 6 to 8 animals and given daily subcutaneous injections of 0.1 ml sesame oil with or without added steroids. The groups were: I – sesame oil; II – 100 μg 19-NT; III – 500 μg 19-NT; IV – 100 μg T.P.; V – 500 μg T. P. After 7 days of injections, seminal vesicles were studied by the transillumination method of Knisely. The seminal vesicles, adrenals and kidneys were then removed and weighed and the vesicles were prepared for routine histological examination. The adrenal and kidney weights, as well as the seminal vesicle contractions, responded to both steroids in a similar manner, however, seminal vesicle weight and histology and in vivo characteristics differed greatly. 19-NT appeared to have very little effect on vesicle weight, in vivo characteristics and histology although contractions were inhibited in 13 of 14 animals so treated. Therefore, when used as the end-point in hormonal reactions, seminal vesicle contractions should not be considered comparable to the usual secondary sexual organ reactivity to hormones.

Leydig cell resistance to the cytotoxic effect of ethylene dimethanesulphonate in the adult rat testis

1985 ◽  
Vol 105 (3) ◽  
pp. 311-NP ◽  
Author(s):  
I. D. Morris
Keyword(s):  
Seminal Vesicle ◽  
Leydig Cell ◽  
Leydig Cells ◽  
Serum Testosterone ◽  
Male Rats ◽  
Cell Physiology ◽  
Testis Weight ◽  
Endocrine Activity ◽  
Adult Rat ◽  
Seminal Vesicle Weight

ABSTRACT Weekly doses of the Leydig cell cytotoxic ethylene dimethanesulphonate (EDS) were administered to adult male rats in an attempt to study the endocrine activity of the testis in the absence of Leydig cells. One week after the first dose serum testosterone and LH concentrations and seminal vesicle weights were close to levels in castrated rats and testicular human chorionic gonadotrophin (hCG) binding was severely depressed. These changes were maintained for a further week but subsequently began to return to, but did not achieve, control levels. After six weekly doses seminal vesicle weight and serum testosterone concentrations were significantly higher than in the castrated rats. Serum LH concentrations were declining towards control values at 4 weeks but had risen again at 6 weeks. Serum FSH concentrations were raised to about 50% of the value in castrated rats throughout the period studied. Testis weight and hCG binding, which initially fell, were partially restored at 6 weeks and spermatogenesis was recovering. The data show that responses of the testis to multiple doses of EDS are similar to those after a single dose. This apparent resistance indicates that the regenerating Leydig cells are functionally different from the mature Leydig cell. The similarities between the maturing Leydig cell seen after EDS destruction and those in the immature rat suggest that EDS will provide a valuable model for the investigation of Leydig cell physiology. J. Endocr. (1985) 105, 311–316

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