Efficacy and safety of intralesional injection of vitamin D 3 versus tuberculin PPD in the treatment of plantar warts: A comparative controlled study

Author(s):  
Nahla Elsayed Ghaly ◽  
Amal Ahmad El‐Ashmawy ◽  
Mai Abou Zeid ◽  
Engi Seif E. Shaker
2015 ◽  
Vol 20 (2) ◽  
pp. 118-122 ◽  
Author(s):  
Habibullah Aktaş ◽  
Can Ergin ◽  
Betül Demir ◽  
Özlem Ekiz

Background: Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts. Aim: To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts. Methods: Twenty patients with single or multiple plantar warts were included in this study. Vitamin D3 (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals. Results: In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed. Conclusion: Intralesional vitamin D3 may be an effective treatment option for warts.


Author(s):  
Krishnakumar M. Nandgaye ◽  
Santoshi B. Kadam ◽  
Dr. Prashant J. Palkar

We performed a study to compare the efficacy of Vitamin D3 oral solution with a conventional tablets and capsules in hypovitaminosis D patients. One hundred eighty subjects were divided into three different groups and received vitamin D3 60000 IU per week for eight weeks either in the form of an oral solution or a tablet or a capsule. A significant increase in serum 25(OH)D was observed in vitamin D3 oral solution from baseline (P=0.0001) as compared to a tablet(P=0.0001) and capsule (P=0.0001). A significant decrease in iPTH levels was seen in the vitamin D3 oral solution group from baseline (P=0.0001) and also as compared to a tablet(P=0.0001) and capsule (P=0.0001). Oral solution of vitamin D3 is a nanotechnology-based formulation which was found to be effective and safe. Thus, treatment with vitamin D3 oral solution in hypovitaminosis D patients may result in faster and higher improvement in the normalization of vitamin D levels.


2019 ◽  
Vol 87 (12) ◽  
pp. 4967-4974
Author(s):  
NAHLA R. GHALY, M.D.; AMAL A. EL-ASHMAWY, M.D. ◽  
MAI M.G. ABOU ZEID, M.Sc.

2019 ◽  
Vol 32 (3) ◽  
Author(s):  
Ibrahim M. Abdel Kareem ◽  
Ibrahim M. Ibrahim ◽  
Sameh F. F. Mohammed ◽  
Ahmed Abo‐Bakr Ahmed

2014 ◽  
Vol 1 (1) ◽  
pp. 42-46
Author(s):  
L. Yuskiv ◽  
V. Vlizlo

Aim. To investigate the vitamin D status in highly productive cows during winter housing period and effect of cholecalciferol by various ways of vitamin D 3 injection to cows in last days of gestation and after calving. Methods. Enzyme-linked immunoassay, spectrophotometry. Results. It has been stated that intramuscular injection of cholecalciferol into cows caused increase of the vitamin D 3 active metabolite – 25-OHD 3 , calcium, phosphorus and magnesium levels together with decrease of alkaline phosphatase level in pre- and post-natal periods. Oral supplementation makes little infl uence on the studied blood parameters of cows. Conclusions. Extrabuccal administration and oral supplementation of cholecalciferol in winter housing period to high-yield cows in the last days of gestation and after calving is accompanied by increased levels of its metabolites and their effect on mineral metabolism in the postnatal period. The nature of these changes depends on the mode of vitamin D administration and the physiological state of the cows.


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