Aim:
The aim of this study is to investigate the efficacy of thiol disulfide homeostasis and Ischemia Modified
Albumin (IMA) values in predicting the technical difficulties that might be encountered during laparoscopic cholecystectomy.
Materials and Methods:
The study included 65 patients who underwent laparoscopic cholecystectomy due to cholelithiasis at
the General Surgery Clinic of Ankara Numune Training and Research Hospital. All patients’ demographic data, previous
history of cholecystitis, a history of chronic illness, preoperative white blood count (WBC), liver function tests (AST, ALT),
amylase and lipase levels, intra-operative adhesion score, the ultrasonographic appearance of gallbladder, duration on hospital
stay, duration of operation, thiol disulfide and IMA values were evaluated.
Results:
Native thiol and total thiol averages were higher in patients without a history of cholecystitis, on the other hand,
disulfide, disulfide/native thiol rate, disulfide/total thiol rate, native thiol/total thiol rate and IMA averages were higher in
patients with a history of cholecystitis. While there was a statistically significant negative correlation between native and total
thiol values and age, duration of surgery and duration of hospital stay; IMA, disulfide, disulfide/Total thiol, Native/Total thiol
and disulfide/Native thiol rates were higher in older patients with a longer duration of surgery and hospital stay. In addition,
preoperative IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol were observed to increase as the
degree of intraoperative pericholecystic adhesion increased.
Conclusion:
We believe that the evaluation of thiol disulfide homeostasis and IMA parameters prior to laparoscopic
cholecystectomy can be used as an effective method for predicting intraoperative difficulties.
Evaluation of ischemia-modified albumin in anemia associated to chronic kidney disease
