A case report of an extremely rare type of cardiac tumor: Primary cardiac angiofibroma

Cardiac angiofibroma is a very rare diagnosis when a patient develops an intracardiac mass. It is a primary benign cardiac tumor with a scarcity of information in the literature. This case report illustrates a 26-year-old man with a complaint of chronic chest tightness who was firstly diagnosed with right ventricle tumor by echocardiography then underwent cardiac MRI which confirmed the presence of a highly-vascular tumor with radiologically benign behavior. Then his tumor was excised, his postoperative course was uncomplicated and he was well within almost 2 months after discharge. Ultimately the histopathologic findings demonstrated vascular and stromal tissue in favor of angiofibroma and excluded the other diagnoses with IHC and trichrome staining. Angiofibroma is a benign, highly vascular tumor, mostly discovered in the nasopharynx. When it is found in the heart, CMR and pathology are pivotal to rule in its diagnosis. It is isointense in T1 weighted and hyperintense in T2 weighted sequences with intense enhancement following contrast injection. Its pathology contains an admixture of vasculatures with CD31 positive immunoreactivity for endothelial cells and fibrotic tissue with bluish coloration in trichrome staining. Eventually, its treatment includes merely surgical excision given its benign nature.

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A case report of an extremely rare type of cardiac tumor: Primary Cardiac Angiofibroma

10.22541/au.163759191.13361738/v1 ◽

2021 ◽

Author(s):

Milad Gholizadeh Mesgarha ◽

Aisa Talebi ◽

Sam Zeraatian Nejad Davani ◽

Ali Saberi Shahrbabaki ◽

Arash Pour Mohammad ◽

...

Keyword(s):

Case Report ◽

Cardiac Tumor ◽

Surgical Excision ◽

Vascular Tumor ◽

Rare Type ◽

Stromal Tissue ◽

Benign Nature ◽

Benign Cardiac Tumor ◽

Positive Immunoreactivity ◽

Weighted Sequences

Cardiac angiofibroma is a very rare diagnosis when a patient develops an intracardiac mass. It is a primary benign cardiac tumor with a scarcity of information in the literature. This case report illustrates a 26-year-old man with a complaint of chronic chest tightness who was firstly diagnosed with right ventricle tumor by echocardiography then underwent cardiac MRI which confirmed the presence of a highly-vascular tumor with radiologically benign behavior. Then his tumor was excised, his postoperative course was uncomplicated and he was well within almost 2 months after discharge. Ultimately the histopathologic findings demonstrated vascular and stromal tissue in favor of angiofibroma and excluded the other diagnoses with IHC and trichrome staining. Angiofibroma is a benign, highly vascular tumor, mostly discovered in the nasopharynx. When it is found in the heart, CMR and pathology are pivotal to rule in its diagnosis. It is isointense in T1 weighted and hyperintense in T2 weighted sequences with intense enhancement following contrast injection. Its pathology contains an admixture of vasculatures with CD31 positive immunoreactivity for endothelial cells and fibrotic tissue with bluish coloration in trichrome staining. Eventually, its treatment includes merely surgical excision given its benign nature.

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Prolonged Survival in Patients with Metastatic HER2-Positive Inflammatory Breast Cancer: A Case Report and Review of the Literature

Case Reports in Oncology ◽

10.1159/000516760 ◽

2021 ◽

pp. 1071-1079

Author(s):

Jennifer Y. Ge ◽

Beth Overmoyer

Keyword(s):

Breast Cancer ◽

Case Report ◽

Inflammatory Breast Cancer ◽

Targeted Therapies ◽

De Novo ◽

Review Of The Literature ◽

Her2 Positive ◽

Rare Type ◽

Favorable Prognosis ◽

Poor Outcomes

Inflammatory breast cancer (IBC) is a rare type of breast cancer that is associated with poor outcomes compared with non-IBC. Overexpression of HER2 is enriched in IBC, and those with HER2-positive disease have a relatively favorable prognosis, with improved survival over the last two decades driven by the advent of novel targeted therapies. Here, we present two patients who have survived for over 10 years after being diagnosed with de novo metastatic HER2-positive IBC. We review the data for the treatments available for metastatic HER2-positive IBC and the evolving treatment recommendations for this disease.

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Mood symptoms Associated with CADASIL Syndrome: A Case Report

CNS Spectrums ◽

10.1017/s1092852920002278 ◽

2021 ◽

Vol 26 (2) ◽

pp. 144-144

Author(s):

Asad Shaikh ◽

Joel Idowu

Keyword(s):

Case Report ◽

Clinical Symptoms ◽

Psychiatric Symptoms ◽

Small Vessel Disease ◽

Altered Mental Status ◽

Hereditary Disease ◽

African American Female ◽

Psychiatric Disturbance ◽

Rare Type ◽

Parietal Lobes

AbstractObjectiveTo discuss the psychiatric symptoms that are associated with CADASIL syndrome Abstract Cerebral:Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare type of hereditary disease involving the small cerebral vessels. The clinical symptoms are various and include recurrent ischemic strokes, migraine with aura, seizures with epilepsy, psychiatric problems such as mood disturbances, and progressive cognitive decline leading to dementia. This disease needs awareness amongst the psychiatrists even though it is discussed much more in neurology literature. Psychiatric symptoms are seen in 20–41% of patients with CADASIL syndrome (1, 2). Psychiatric symptoms are actually the initial presentation in 15% of the cases. (3) The psychiatric disturbance most reported are mood disturbances (9–41%) especially depression. Here a 42-year-old African American female was brought to the hospital emergency room after she was found wandering in the streets. Psychiatry was consulted for altered mental status. Upon evaluation by the psychiatric consult service she was only oriented to person, depressed, anxious and complaining of headaches. Initial CT scan showed marked small vessel disease and old lacunar infarcts in the basal ganglia and right corona radiata. Magnetic Resonance Imaging (MRI) of the brain showed acute infarcts in the right posterior frontal and right parietal lobes along with old infarcts. Her symptoms and findings on imaging were consistent with CADASIL syndrome. Once the diagnosis was confirmed and prior records were obtained patient was resumed on an antidepressant and anxiolytic.ConclusionThe purpose of this case report was to discuss psychiatric symptoms associated with CADASIL syndrome. Although there has been research showing a relationship between vascular disease and depression, a review of the literature suggests that there needs to be more research done to explore other psychiatric disturbances that may be seen with this syndrome. Psychiatric symptoms that are untreated can have the potential to further impact the quality of life therefore psychiatrists need to be aware of this syndrome in order to treat these patients promptly.References1 https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0778-8 2 http://dx.doi.org/10.32474/OJNBD.2018.01.000101 3 https://pdfs.semanticscholar.org/47f6/5952ee3c5dcf2a61345f704914b17fa8dc0d.pdf

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Primary small cell type of non-Hodgkin lymphoma of the colon: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-020-02500-y ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Eyal Meir ◽

Chovav Handler ◽

Uri Kaplan ◽

Doron Kopelman ◽

Ossama A. Hatoum

Keyword(s):

Case Report ◽

Hodgkin Lymphoma ◽

Small Cell ◽

Primary Lymphoma ◽

Cell Type ◽

Rare Type ◽

Case Presentation ◽

Carcinoma Of The Colon ◽

Non Hodgkin Lymphoma ◽

High Level

Abstract Introduction Primary lymphoma of the colon is exceedingly rare and comprises 0.2–1% of all colon tumors. The most common subtype of lymphoma in the colon is non-Hodgkin lymphoma. Symptoms are often nonspecific, and treatment varies between chemotherapy alone and a combination of surgery and chemotherapy. Case presentation We describe a case of a Ashkenazi Jew patient who presented in the typical way that carcinoma of the colon might present but turned out to have a very rare type of tumor in both its histology and its location. Conclusion There was apparent discordance between the relative bulkiness and gross appearance of the tumor with the unrevealing result of the biopsies, demanding a high level of suspicion as to the actual presence and possible type of such a tumor in the future.

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STUDY OF CLINICAL CASES OF MYOCHE’S MYOPATHY AND DIFFERENTIAL DIAGNOSIS WITH OTHER TYPES OF ADVERSE MYOPATHIES

Odes’kij medičnij žurnal (The Odessa Medical Journal) ◽

10.54229/2226-2008-2021-5-14 ◽

2021 ◽

Author(s):

K. Sarazhyna ◽

Y. Solodovnikova ◽

A. Son

Keyword(s):

Case Report ◽

Genetic Testing ◽

Skeletal Muscles ◽

Molecular Genetic ◽

Clinical Signs ◽

Lower Limbs ◽

Molecular Genetic Testing ◽

Membrane Repair ◽

Rare Type ◽

A Cell

Markesbery-Griggs myopathy, Miyoshi type (MM) is a rare type of myopathy, a form muscular dystrophy with the main involvement of the lower girdle and distal parts of the legs. Due to complexity of genetic testing, the diagnosis is mainly made on the neurological examination of the patient, which adds value to this case report. The childhood or adolescence onset of the disease is characterized initially by the calf muscles` wasting, accompanied by the severe elevation of the serum creatine kinase, as well as a slowly progressive ascending course. The disease refers to dysferlinopathies with various mutations in the DYSF gene. The dysferlin protein is localized in the plasma membrane and in the T-tubule system of skeletal muscles. Physiologically, skeletal muscles are constantly exposed to micromembrane lesions. Depending on the severity, these damages are restored using various complexes. One of the main reparative complexes is the dysferlin-dependent mechanism. Mutations can lead to a defect in the membrane repair, causing the influx of Ca 2+ into the cell, which leads to a cell`s destruction. There are three genetically identifiable types of Miyoshi myopathy: MMD1, MMD2, MMD3. The main clinical signs of the disease are the muscle weakness and atrophy, with predominant involvement of the distal parts of the lower limbs, especially in the gastrocnemius and plantar muscles. The MM causes tip toe walking disturbances and difficulties in climbing the stairs. Progression of the disease and further atrophy leads to the wasting of the lower girdle muscles, mainly gluteal ones. Peculiarity of these myopathies is the absence of cardiomyopathy, due to the immunity of cardiomyocytes to a deficiency of the protein dysferelin. Diagnosis is made on the basis of muscle biopsy and molecular genetic testing. The gold standard is immunoblotting or immunohistochemistry. One of treatment methods is the use of improperly folded dysferlin (treatment with a proteasome inhibitor MG-132) in fibroblasts with restoration of membrane sealing. The aim of this case report is to present an example of a possible clinical diagnosis of MM in a young man, in the absence of opportunities for molecular genetic testing.

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External supravesical hernia is a rare type of abdominal wall hernia: A case report

Journal of Shaheed Suhrawardy Medical College ◽

10.3329/jssmc.v7i1.31790 ◽

2017 ◽

Vol 7 (1) ◽

pp. 40-41 ◽

Cited By ~ 1

Author(s):

Pankaj Kumar Saha ◽

Ratna Rani Roy ◽

Mohammad Emrul Hasan Khan ◽

Md Mamunur Rahman ◽

Kazi Shafiqul Alam ◽

...

Keyword(s):

Case Report ◽

Inguinal Hernia ◽

Abdominal Wall ◽

Abdominal Wall Hernia ◽

Surgical Anatomy ◽

Rare Type ◽

First Case ◽

Made In

The first case of external supravesical hernia was made in 1804; but it is so rare that it is very difficult to find any case reported in Bangladesh. Here a case of external supravesical hernia is described in a male who was presented with a left sided direct incomplete reducible inguinal hernia. This report aims to review and discuss the surgical anatomy of these rare supravesical hernias and calls attention to the confusing presentation and treatment of this conditionJ Shaheed Suhrawardy Med Coll, 2015; 7(1):40-41

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Lateral Swivel Dislocation of the Hindfoot : A Case Report and Literature Review

Journal of Foot and Ankle Surgery Asia Pacific ◽

10.5005/jp-journals-10040-1027 ◽

2015 ◽

Vol 2 (1) ◽

pp. 41-43

Author(s):

Rajesh Kapila ◽

Partap singh Verka ◽

Radhe sham Garg ◽

Mannan Ahmed

Keyword(s):

Case Report ◽

Literature Review ◽

Subtalar Joint ◽

Asia Pacific ◽

Talonavicular Joint ◽

Review Of Literature ◽

Rare Type ◽

Present Case Report ◽

Comprehensive Review ◽

Type Of Injury

ABSTRACT Lateral swivel dislocation, a subtype pattern of dislocations occurring at mid tarsal joint is a rare type of injury. A medially or laterally directed force applied to the forefoot causes dislocation of the talonavicular joint but not subtalar joint. The calcaneum alongwith the remaining foot swivels on the intact interosseous talocalcaneal ligament. The present case report is a more rare lateral swivel type of dislocation of talonavicular joint in a 25-year-old male. The article also presents a comprehensive review of literature and management of such type of injuries of the hindfoot . How to cite this article Kapila R, Verka Ps, Garg Rs, Ahmed M. Lateral Swivel Dislocation of the Hindfoot: A Case Report and Literature Review. J Foot Ankle Surg (Asia-Pacific) 2015;2(1): 41-43.

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