scholarly journals Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study

2017 ◽  
Vol 282 (4) ◽  
pp. 340-352 ◽  
Author(s):  
K. Santalahti ◽  
A. Havulinna ◽  
M. Maksimow ◽  
T. Zeller ◽  
S. Blankenberg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Growth Factor ◽  
General Population ◽  
Hepatocyte Growth Factor ◽  
Prospective Cohort Study ◽  
Plasma Levels ◽  
Prospective Cohort ◽  
Placental Growth Factor ◽  
Hepatocyte Growth

Association between placental growth factor levels in early onset preeclampsia with the occurrence of postpartum hemorrhage: A prospective cohort study

2012 ◽  
Vol 2 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Sanjib Kumar Ghosh ◽  
Shashi Raheja ◽  
Anita Tuli ◽  
Chitra Raghunandan ◽  
Sneh Agarwal
Keyword(s):  
Cohort Study ◽  
Growth Factor ◽  
Prospective Cohort Study ◽  
Postpartum Hemorrhage ◽  
Early Onset ◽  
Prospective Cohort ◽  
Placental Growth Factor ◽  
Early Onset Preeclampsia

scholarly journals Impact of replacing or adding placental growth factor on Down syndrome screening: A prospective cohort study

2021 ◽  
Author(s):  
Wing To Angela Sin ◽  
Liona C Poon ◽  
Piya Chaemsaithong ◽  
Yi Man Isabella Wah ◽  
Shuk Yi Annie Hui ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cohort Study ◽  
Growth Factor ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Placental Growth Factor ◽  
Down Syndrome Screening

Physical comorbidity in Older-Age Bipolar Disorder (OABD) compared to the general population - a 3-year longitudinal prospective cohort study

2021 ◽  
Author(s):  
Alexandra J.M. Beunders ◽  
Almar A.L. Kok ◽  
Panagiotis C. Kosmas ◽  
Aartjan T.F. Beekman ◽  
Caroline M. Sonnenberg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Older Age

scholarly journals Response to Letter Regarding Article, “Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population: A Prospective Cohort Study”

Circulation ◽  
2014 ◽  
Vol 130 (24) ◽  
Author(s):  
Mette Christoffersen ◽  
Ruth Frikke-Schmidt ◽  
Peter Schnohr ◽  
Gorm B. Jensen ◽  
Børge G. Nordestgaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Ischemic Heart ◽  
Age Related

scholarly journals Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study

BMC Medicine ◽  
2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Daniel J. Gottlieb ◽  
Jeffrey M. Ellenbogen ◽  
Matt T. Bianchi ◽  
Charles A. Czeisler
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Motor Vehicle ◽  
Motor Vehicle Crash ◽  
Crash Risk ◽  
Vehicle Crash ◽  
Sleep Deficiency

Epidemiology of Polypharmacy in the General Population: 27-Year Prospective Cohort Study

2020 ◽  
Vol 21 (8) ◽  
pp. 1177-1179
Author(s):  
Silvan Licher ◽  
Brenda C.T. Kieboom ◽  
Loes E. Visser ◽  
Gijsbertus Ziere ◽  
Rikje Ruiter ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort

scholarly journals Sperm mitochondrial DNA biomarkers and couple fecundity

2020 ◽  
Vol 35 (11) ◽  
pp. 2619-2625
Author(s):  
Allyson J Rosati ◽  
Brian W Whitcomb ◽  
Nicole Brandon ◽  
Germaine M Buck Louis ◽  
Sunni L Mumford ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
National Institutes Of Health ◽  
Fertility Treatment ◽  
Semen Parameters ◽  
Lower Probability ◽  
Lower Odds

Abstract STUDY QUESTION Do sperm mitochondrial DNA measures predict probability of pregnancy among couples in the general population? SUMMARY ANSWER Those with high sperm mitochondrial DNA copy number (mtDNAcn) had as much as 50% lower odds of cycle-specific pregnancy, and 18% lower probability of pregnancy within 12 months. WHAT IS KNOWN ALREADY Semen parameters have been found to poorly predict reproductive success yet are the most prevalent diagnostic tool for male infertility. Increased sperm mtDNAcn and mitochondrial DNA deletions (mtDNAdel) have been associated with decreased semen quality and lower odds of fertilization in men seeking fertility treatment. STUDY DESIGN, SIZE, DURATION A population-based prospective cohort study of couples discontinuing contraception to become pregnant recruited from 16 US counties from 2005 to 2009 followed for up to 16 months. PARTICIPANTS/MATERIALS, SETTING, METHODS Sperm mtDNAcn and mtDNAdel from 384 semen samples were assessed via triplex probe-based quantitative PCR. Probability of pregnancy within 1 year was compared by mitochondrial DNA, and discrete-time proportional hazards models were used to evaluate the relations with time-to-pregnancy (TTP) with adjustment for covariates. MAIN RESULTS AND THE ROLE OF CHANCE Higher sperm mtDNAcn was associated with lower pregnancy probability within 12 months and longer TTP. In unadjusted comparisons by quartile (Q), those in Q4 had a pregnancy probability of 63.5% (95% CI: 53.1% to 73.1%) compared to 82.3% (95% CI: 73.2% to 89.9%) for Q1 (P = 0.002). Similar results were observed in survival analyses adjusting for covariates to estimate fecundability odds ratios (FORs) comparing mtDNAcn in quartiles. Relative to those in Q1 of mtDNAcn, FORs (95% CI) were for Q2 of 0.78 (0.52 to 1.16), Q3 of 0.65 (0.44 to 0.96) and Q4 of 0.55 (0.37 to 0.81), and this trend of decreasing fecundability with increasing mtDNAcn quartile was statistically significant (FOR per log mtDNAcn = 0.37; P < 0.001). Sperm mtDNAdel was not associated with TTP. LIMITATIONS, REASONS FOR CAUTION This prospective cohort study consisted primarily of Caucasian men and women and thus large diverse cohorts are necessary to confirm the associations between sperm mtDNAcn and couple pregnancy success in other races/ethnicities. WIDER IMPLICATIONS OF THE FINDINGS Our results demonstrate that sperm mtDNAcn has utility as a biomarker of male reproductive health and probability of pregnancy success in the general population. STUDY FUNDING/COMPETING INTEREST(S) This work was funded in part by the National Institute of Environmental Health Sciences, National Institutes of Health (R01-ES028298; PI: J.R.P.) and the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (Contracts N01-HD-3-3355, N01-HD-3-3356 and N01-HD-3-3358). The authors declare no competing interests. TRIAL REGISTRATION NUMBER N/A

Mediterranean diet and mortality in the elderly: a prospective cohort study and a meta-analysis

2018 ◽  
Vol 120 (8) ◽  
pp. 841-854 ◽  
Author(s):  
Marialaura Bonaccio ◽  
Augusto Di Castelnuovo ◽  
Simona Costanzo ◽  
Alessandro Gialluisi ◽  
Mariarosaria Persichillo ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Mediterranean Diet ◽  
Prospective Cohort Study ◽  
Prospective Studies ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
The Elderly ◽  
Prolonged Survival

AbstractThe Mediterranean diet (MD) has been associated with prolonged survival in the general population, but no meta-analysis has apparently investigated the potential health benefits in relation to mortality in the elderly. We performed a longitudinal analysis on 5200 individuals aged ≥65 years identified within the general population recruited in the Moli-sani study cohort (2005–2010). Adherence to the MD was appraised by the a priori Mediterranean diet score (MDS; range 0–9). Survival estimates were derived using Cox regression and competing risk models. For the meta-analysis, PubMed and Scopus databases were searched from inception until April 2018 to identify prospective studies on the MD and death risk in the elderly. Over a median follow-up of 8·1 years, a total of 900 deaths were ascertained in the elderly sub-sample of the Moli-sani cohort. A one-point increase in the MDS was associated with lower risk of all-cause, coronary artery disease/cerebrovascular and non-cardiovascular/non-cancer mortality (multi-variable hazard ratio (HR)=0·94; 95 % CI 0·90, 0·98; HR=0·91; 95 % CI 0·83, 0·99 and HR=0·89; 95 % CI 0·81, 0·96, respectively). In a meta-analysis of seven prospective studies, including our results, for a total of 11 738 participants and 3874 deaths, one-point increment in MDS was associated with 5 % (4–7 %) lower risk of all-cause death. An inverse linear dose–response relationship was found from a meta-analysis including three studies. In conclusion, a prospective cohort study and a meta-analysis showed that closer adherence to the MD was associated with prolonged survival in elderly individuals, suggesting the appropriateness for older persons to adopt/preserve the MD to maximise their prospects for survival.

Hepatocyte growth factor serum and plasma levels are elevated in patients with inflammatory bowel disease (IBD)

1998 ◽  
Vol 114 ◽  
pp. A1092
Author(s):  
A. Sturm ◽  
R. Schatton ◽  
C. Schulte ◽  
A. Becker ◽  
H. Goebell ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Bowel Disease ◽  
Plasma Levels ◽  
Inflammatory Bowel ◽  
Hepatocyte Growth

Spontaneous abortion: A prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants

2006 ◽  
Vol 85 (4) ◽  
pp. 467-475 ◽  
Author(s):  
L. Buss ◽  
J. Tolstrup ◽  
C. Munk ◽  
T. Bergholt ◽  
B. Ottesen ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Spontaneous Abortion ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Younger Women ◽  
Risk Determinants
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