Principal component analysis denoising improves sensitivity of MR diffusion to detect white matter injury in neuroHIV

2022 ◽  
Author(s):  
Ryan P. Bell ◽  
Christina S. Meade ◽  
Syam Gadde ◽  
Sheri L. Towe ◽  
Shana A. Hall ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
White Matter ◽  
Principal Component ◽  
Component Analysis ◽  
White Matter Injury ◽  
Mr Diffusion

scholarly journals Multimodal principal component analysis to identify major features of white matter structure and links to reading

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0233244 ◽  
Author(s):  
Bryce L. Geeraert ◽  
Maxime Chamberland ◽  
R. Marc Lebel ◽  
Catherine Lebel
Keyword(s):  
Principal Component Analysis ◽  
White Matter ◽  
Principal Component ◽  
Component Analysis

scholarly journals Abnormal white matter integrity in antipsychotic-naïve first-episode psychosis patients assessed by a DTI principal component analysis

2015 ◽  
Vol 162 (1-3) ◽  
pp. 14-21 ◽  
Author(s):  
Patricia Alvarado-Alanis ◽  
Pablo León-Ortiz ◽  
Francisco Reyes-Madrigal ◽  
Rafael Favila ◽  
Oscar Rodríguez-Mayoral ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
White Matter ◽  
Principal Component ◽  
Component Analysis ◽  
First Episode Psychosis ◽  
White Matter Integrity ◽  
First Episode ◽  
Episode Psychosis

scholarly journals Multimodal principal component analysis to identify major features of white matter structure and links to reading

2020 ◽  
Author(s):  
Bryce L. Geeraert ◽  
Maxime Chamberland ◽  
R. Marc Lebel ◽  
Catherine Lebel
Keyword(s):  
Principal Component Analysis ◽  
White Matter ◽  
Principal Components ◽  
Bayes Factor ◽  
Diffusion Tensor ◽  
Magnetization Transfer ◽  
Principal Component ◽  
Single Pulse ◽  
Component Analysis ◽  
Axonal Diameter

ABSTRACTThe role of white matter fibers in reading has been established by diffusion tensor imaging (DTI), but DTI cannot identify specific microstructural features driving these relationships. Neurite orientation dispersion and density imaging (NODDI), inhomogeneous magnetization transfer (ihMT) and multicomponent driven equilibrium single-pulse observation of T1/T2 (mcDESPOT) can be used to link more specific aspects of white matter microstructure and reading due to their sensitivity to axonal packing and fiber coherence (NODDI) and myelin (ihMT and mcDESPOT). We applied principal component analysis (PCA) to combine DTI, NODDI, ihMT and mcDESPOT measures (10 in total), identify major features of white matter structure, and link these features to both reading and age. Analysis was performed for nine reading-related tracts in 46 neurotypical 6-16 year olds. We identified three principal components (PCs) which explained 79.5% of variance in our dataset. PC1 probed tissue complexity, PC2 described myelin and axonal packing, while PC3 was related to axonal diameter. Mixed effects models regressions did not identify any relationships between principal components and reading skill. Further Bayes factor analysis revealed that absence of relationships was not due to low power. PC1 suggested increases in tissue complexity with age in the left arcuate fasciculus, while PC2 suggested increases in myelin and axonal packing with age in the bilateral arcuate, inferior longitudinal, inferior fronto-occipital fasciculi, and splenium. Multimodal white matter imaging and PCA produce microstructurally informative, powerful principal components which can be used by future studies of development and cognition.

A German version of the Intermittent Claudication Questionnaire (ICQ): cultural adaptation and validation

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 333-342 ◽  
Author(s):  
Kirchberger ◽  
Finger ◽  
Müller-Bühl
Keyword(s):  
Principal Component Analysis ◽  
Intermittent Claudication ◽  
Completion Time ◽  
Short Form ◽  
Principal Component ◽  
Component Analysis ◽  
German Version ◽  
Average Completion Time ◽  
Sf 36 ◽  
Related Quality

Background: The Intermittent Claudication Questionnaire (ICQ) is a short questionnaire for the assessment of health-related quality of life (HRQOL) in patients with intermittent claudication (IC). The objective of this study was to translate the ICQ into German and to investigate the psychometric properties of the German ICQ version in patients with IC. Patients and methods: The original English version was translated using a forward-backward method. The resulting German version was reviewed by the author of the original version and an experienced clinician. Finally, it was tested for clarity with 5 German patients with IC. A sample of 81 patients were administered the German ICQ. The sample consisted of 58.0 % male patients with a median age of 71 years and a median IC duration of 36 months. Test of feasibility included completeness of questionnaires, completion time, and ratings of clarity, length and relevance. Reliability was assessed through a retest in 13 patients at 14 days, and analysis of Cronbach’s alpha for internal consistency. Construct validity was investigated using principal component analysis. Concurrent validity was assessed by correlating the ICQ scores with the Short Form 36 Health Survey (SF-36) as well as clinical measures. Results: The ICQ was completely filled in by 73 subjects (90.1 %) with an average completion time of 6.3 minutes. Cronbach’s alpha coefficient reached 0.75. Intra-class correlation for test-retest reliability was r = 0.88. Principal component analysis resulted in a 3 factor solution. The first factor explained 51.5 of the total variation and all items had loadings of at least 0.65 on it. The ICQ was significantly associated with the SF-36 and treadmill-walking distances whereas no association was found for resting ABPI. Conclusions: The German version of the ICQ demonstrated good feasibility, satisfactory reliability and good validity. Responsiveness should be investigated in further validation studies.

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