Update molecular diagnosis and treatment on salivary gland tumors - Mammary Analog Secretory Carcinoma

BACKGROUND: Secretory carcinoma (SC) of the salivary gland, also known as mammary analog secretory carcinoma, is a rare tumor in the parotid gland. This kind of tumor is characterized by generally indolent clinical behavior and expression of a break in the ETV6 gene. CASE REPORT: We present a unique case of secretory carcinoma and show its favorable prognoses. CONCLUSION: Secretory carcinoma of the salivary gland is a low-grade carcinoma with a favorable prognosis. It has low regional lymph node and distant metastasis potential. Due to the possibility of misdiagnosis, immunohistochemical studies and FISH are suggested. The most effective treatment is complete surgical excision with negative surgical margins.

Download Full-text

Mammary analog secretory carcinoma of salivary gland: Cytologic diagnosis and differential diagnosis of an unreported entity

Diagnostic Cytopathology ◽

10.1002/dc.21766 ◽

2012 ◽

Vol 41 (3) ◽

pp. 239-241 ◽

Cited By ~ 29

Author(s):

Latha Pisharodi

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Secretory Carcinoma ◽

Cytologic Diagnosis ◽

Mammary Analog Secretory Carcinoma

Download Full-text

Mammary analog secretory carcinoma of salivary gland in a 5 year old: Case report

International Journal of Pediatric Otorhinolaryngology Extra ◽

10.1016/j.pedex.2014.09.003 ◽

2014 ◽

Vol 9 (4) ◽

pp. 163-165 ◽

Cited By ~ 7

Author(s):

Matthew Keisling ◽

Michael Bianchi ◽

Judy Mae Pascasio

Keyword(s):

Salivary Gland ◽

Case Report ◽

Secretory Carcinoma ◽

Mammary Analog Secretory Carcinoma

Download Full-text

The cytopathologic features of mammary analog secretory carcinoma and its mimics

CytoJournal ◽

10.4103/1742-6413.139726 ◽

2014 ◽

Vol 11 ◽

pp. 24 ◽

Cited By ~ 20

Author(s):

T. Danielle Samulski ◽

Virginia A. LiVolsi ◽

Zubair Baloch

Keyword(s):

Salivary Gland ◽

Mucoepidermoid Carcinoma ◽

Needle Aspiration ◽

Definite Diagnosis ◽

Secretory Carcinoma ◽

Warthin Tumor ◽

Fine Needle ◽

Monomorphic Population ◽

Mammary Analog Secretory Carcinoma ◽

Foamy Cytoplasm

Mammary Analogue Secretory Carcinoma (MASC) is a newly recognized neoplasm of the salivary gland, first described in 2010. This tumor harbors a unique translocation, t(12;15)(p13;q25) that results in the fusion of ETV6 with NTRK3 which produces a transformative chimeric tyrosine kinase. To date, few cases of MASC sampled by fine needle aspiration have been reported. Cytologically, MASC can be confused with other oncocytic salivary gland tumors, including Warthin-tumor, acinic cell carcinoma (AciCC) and mucoepidermoid carcinoma. It is characterized by a monomorphic population of lesional cells with round nuclei, prominent nucleoli and abundant, eosinophilic foamy cytoplasm; forming papillary groups with transgressing vessels. Though, based on cytomorphology alone, the definite diagnosis can be challenging, in conjunction with available clinical clues (i.e. male patient, extra-parotid site) MASC should be included in the differential diagnosis of FNA specimens diagnosed as oncocytic salivary gland neoplasms or suspicious for AciCC. Here we present a case of MASC with FNA sampling at our institution.

Download Full-text