Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome

Introduction: Aetiology and pathogenesis of Oral Lichen Planus (OLP) has been focus of research since a long time and various aetiological factors like autoimmunity, heredity, drugs, dental materials, psychological factors, especially stress and anxiety have been reported to be associated with this disease. Few studies in past have found significant elevations in C-Reactive Protein (CRP) levels in individuals who reported to be having chronic stress. Both altered salivary CRP levels and psychological stress have been reported in OLP patients. To the best of our knowledge no such studies have been conducted in past, so a need was felt to conduct a study to evaluate and also correlate salivary CRP and psychological factors in OLP patients. Aim: To evaluate salivary CRP and psychological factors and assess only possible correlation between them in patients with OLP. Materials and Methods: This cross-sectional study included of two groups: Group A- consisting of 33 individuals clinically diagnosed with OLP and Group B- consisting of 33, age and gender matched healthy individuals. Hospital Anxiety and Depression Scale (HADS) was used for all the participants to evaluate the psychological factors. Salivary CRP levels were evaluated using Mispa i2 Nephelometry. Statistical analysis was done using SPSS software. Results: Mean salivary CRP value among cases was 3.42±2.786 and among controls was 2.84±.848. Mean HADS score among cases was 6.60±2.796 and among controls was 2.70±.948. Mean Salivary CRP and HADS values were higher in OLP patients compared to controls. However, no statistical significant association could be established between CRP and HADS in patients with OLP (p=0.200). Conclusion: No correlation between psychological status and CRP levels could be established in patients with OLP. CRP couldbe used as a diagnostic marker in oral premalignantlesions.

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Role of Zinc in Improvement, Prevention, and Treatment of the Noncommunicable Oral Diseases: Review of Literature

Galen Medical Journal ◽

10.31661/gmj.v10i0.2071 ◽

2021 ◽

Vol 10 ◽

pp. 2071

Author(s):

Farzaneh Agha-Hosseini ◽

Mahdieh-Sadat Moosavi ◽

Sanam Talaei

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Burning Mouth Syndrome ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Oral Lesions ◽

Oral Diseases ◽

Burning Mouth ◽

Oral Lichen

Zinc, as the second most abundant trace element present in the living organisms after iron, plays a key role in the structural, catalytic, and signaling felds. Beyond the numerous systemic symptoms of zinc defciency, it may also contribute to diﬀerent processes of oral diseases. The articles were collected from three search engines including PUBMED, GOOGLE SCHOLAR, and SCOPUS. The search keywords are as follows: Zinc, trace elements, zinc defciency, oral diseases, oral lesions, recurrent aphthous stomatitis, oral lichen planus, oral squamous cell carcinoma, burning mouth syndrome, xerostomia, neuropathy. Many diverse articles including original article, case report/case series, and review articles were collected. Several studies have investigated the role of zinc and its defciency in the development of various types of noncommunicable oral lesions including recurrent aphthous stomatitis (RAS), oral lichen planus (OLP), precancerous lesions of the oral cavity (leukoplakia and submucosal fbrosis), oral cancer, xerostomia and burning mouth syndrome, periodontal disease, and Caries. Therefore, the present research was conducted to review the previous studies performed in this feld. [GMJ.2021;10:e2071]

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OI0310 Sleep disturbances in burning mouth syndrome and oral lichen planus

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2014.01.038 ◽

2014 ◽

Vol 117 (5) ◽

pp. e337

Author(s):

Daniela Adamo ◽

Stefania Leuci ◽

Elvira Ruoppo ◽

Massimo Aria ◽

Michele Davide Mignogna

Keyword(s):

Lichen Planus ◽

Sleep Disturbances ◽

Oral Lichen Planus ◽

Burning Mouth Syndrome ◽

Burning Mouth ◽

Oral Lichen

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Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review

Brazilian Oral Research ◽

10.1590/1807-3107bor-2018.vol32.0082 ◽

2018 ◽

Vol 32 (0) ◽

Cited By ~ 6

Author(s):

Janaina Silva Martins HUMBERTO ◽

Jefferson Veronezi PAVANIN ◽

Maria José Alves da ROCHA ◽

Ana Carolina Fragoso MOTTA

Keyword(s):

Nitric Oxide ◽

Systematic Review ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Salivary Biomarkers ◽

Oral Lichen

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GRINSPAN SYNDROME: THE TRIAD

International Journal of Medical Science and Diagnosis Research ◽

10.32553/ijmsdr.v4i10.683 ◽

2020 ◽

Vol 4 (10) ◽

Author(s):

Seema M ◽

Shruti Srinivasan

Keyword(s):

Diabetes Mellitus ◽

Early Detection ◽

Malignant Transformation ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Clinical Manifestations ◽

Prevention And Early Detection ◽

Burning Mouth ◽

Oral Lichen

Lichen Planus is a chronic immunologically mediated mucocutaneous disorder with varied clinical manifestations. The condition might be associated with multiple causative or exacerbation factors. An interesting association of Oral Lichen Planus with Diabetes Mellitus and vascular hypertension is called as Grinspan's syndrome. Since its inception has been an arena of interest. It has appeared very lucrative to many researchers as it lacks clarity and enhanced ambiguity. A 65 year female patient came with a complaint of burning mouth and difficulty in swallowing since 1 year with H/O Diabetes Mellitus since 8years and hypertension since 2 years. Malignant transformation is the most significant complication of long standing and non healing Lichen Planus. Repeated follow up and biopsies are mandatory for prevention and early detection of malignant transformation. Keywords: Grinspan Syndrome, Hypertrophic Lichen Planus, Esophageal Lichen Planus

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